N ‐ tert ‐Butoxycarbonyl‐ L ‐Leucinal

Abstract

N ‐ tert ‐butoxycarbonyl‐ L ‐leucinal product: N ‐ tert ‐Butoxycarbonyl‐ L ‐leucinal: Boc‐ L ‐leucinal intermediate: Boc‐ L ‐leucine N ‐methyl‐O‐methycarboxamide

A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids

“…Significant effort has been devoted toward the development of their mild and general synthesis in recent years. For example, Weinreb amides can be prepared via carboxylic acids, − acid chlorides, , esters, lactones, amides, and anhydrides . Among them the direct conversion of carboxylic acids to the corresponding Weinreb amides is very attractive.…”

Fmox: A Base‐Labile Aldehyde Protecting Group

“…Synthetically, amino aldehydes are easily accessible through reduction from the diverse pool of amino acids [6][7][8][9][10][11][12][13][14][15][16][17][18][19] or oxidation of amino alcohols. [7,[20][21][22][23] In general, their bifunctional nature opens up the possibility to perform a wide range of both amine and aldehyde based reactions with the same molecule.…”

One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids

“…9,10 Weinreb amides are also widely employed in the total synthesis of natural products. 11,12 Traditionally, Weinreb amides are obtained from carboxylic acids [13][14][15] or their derivatives such as acid chlorides, 1,16 esters, 17,18 lactones, 19 amides, 20 and anhydrides. 21 Among the reported methods, direct conversion of carboxylic acids into the corresponding Weinreb amides is very attractive because of the easy availability of the starting materials.…”