N-fluoro-N-(phenylsulfonyl)benzenesulfonamide

Strategy for Selective Csp2–F and Csp2–Csp2 Formations from Organoplatinum Complexes

“…In addition, the suitable solvents for the reactions with Selectfluor are limited to high polar solvents which have a high coordinating ability such as MeCN, DMF, and H 2 O . However, the NFSI could be used in various organic solvents especially inert and noncoordinating solvents such as CHCl 3 , CH 2 Cl 2 , and toluene . Moreover, the NFSI contains a bulky anionic residue [dibenzenesulfonimide] − having a coordinating ability that could be another distinct parameter to have a different reactivity in comparison with Selectfluor.…”

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

“…This synthesis represents the first report on the base-promoted difluorination of the 9-position of a fluorene ring system utilizing an electrophilic source of fluorine. 449 Crucial to the success of the process was premixing the substrate and Nfluorobenzenesulfonimide, as well as the slow addition of base to this mixture. Additionally, the base and the fluorinating reagent are inert toward each other, and the difluorinated product is formed in high yield without isolation of the monofluorofluorene.…”

“…Thus, the group of Gilead Sciences successfully avoided a risk of using bis­(2methoxyethyl)-aminosulfur trifluoride and could overcome the low efficiency of the Stille coupling. This synthesis represents the first report on the base-promoted difluorination of the 9-position of a fluorene ring system utilizing an electrophilic source of fluorine . Crucial to the success of the process was premixing the substrate and N -fluorobenzenesulfonimide, as well as the slow addition of base to this mixture.…”