N-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes

Abstract

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides has been developed employing novel pentamethylcyclopentadienylruthenium (II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex 2 has proven...

N-coordinated Ru(ii) catalyzed solvent freeN-alkylation of primary amines with alcohols through borrowing hydrogen strategy

“…For that, widely explored ruthenium and iridium-based complexes are promising choices for this conversion because of their excellent activity, especially in situ generated Ru–phosphine complexes, 32 Ru-pincer complexes 33 and Ru-half sandwich complexes. 34…”

Synthesis, crystallographic structure, theoretical analysis, molecular docking studies, electronic properties and biological activity evaluation of ruthenium-complex bearing N-heterocyclic carbene ligand

“…28 Considering the wide variety of ruthenium(II) complexes, this paper only focuses on one class, the Ru-NHC complexes. Ru-NHC complexes have broad catalytic potential in a wide range of synthetic applications, including transfer hydrogenation of ketones, 29,30 metathesis reactions, 31 secondary oxidation of alcohols, 32 N-alkylation of amines, amides oxidation, and sulfonamides 33,34 and Oppenauer-type oxidations. 35,36 In previous studies, we introduced various substituents into ruthenium complexes, and synthesized four ruthenium complexes with MIC values ranging from 0.003 to 0.050 mg mL À1 against Staphylococcus aureus.…”

N-Alkylation of aromatic amines with alcohols by using a commercially available Ru complex under mild conditions

“…To this day, most N -alkylation reactions of amines with alcohols are mainly conducted at high temperatures (>100 °C). 20,21 Very few examples of room-temperature BH N -alkylation are reported in the literature. 16,22–25…”