<i>Mycoplasma pneumoniae</i> downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells

Qin, Lianmei; Liu, Lu; Wu, Yueping; Chen, Yiwen; Wu, Yueyue; Luo, Hongyu; Xi, Yixuan; Xiu, Feichen; Hu, Jun; Chen, Liesong; Wu, Ning; He, Jun; Zeng, Yanhua; Zhu, Chen; You, Xinru

doi:10.1080/21505594.2022.2101746

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…Показано, что увеличение экспрессии гена ММР9 у пациентов с ХОБЛ, являющихся носителями определенных генотипов, повышен риск развития ИВЛассоциированной пневмонии [52]. По результатам опытов на культуре бронхиальных эпителиальных клеток человека показано, что при инфицировании Mycoplasma pneumoniae увеличивалась экспрессия гена MMP9 посредством активации Toll-подобного рецептора-2 (TLR2) и TLR6-зависимого MAPK/NF-κB/ AP-1-сигнального пути, усиливая воспалительную реакцию [53].…”

Section: маркеры иммунного ответа организмаunclassified

Potential predictors of severe course and outcome of community-acquired pneumonia

Volchkova¹,

Titova

Кузубова

et al. 2023

Pulʹmonologiâ (Mosk.)

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Severe pneumonia is a condition with a high risk of death and mandatory hospitalization in the intensive care unit. The incidence of severe pneumonia has increased dramatically during the pandemic of new coronavirus infection. Timely diagnosis and early initiation of adequate treatment of severe pneumonia are crucial for improving survival of critically ill patients.The aim of this review was to analyze published scientific research on molecular markers that allow to objectively assess the severity of pneumonia and to determine treatment tactics based on the predicted outcome upon admission to the hospital. A systematic search was conducted in the electronic databases PubMed, Medline, Web of Science for the period 2019 - 2022.Conclusion. The review focuses on the prognostic role of a number of markers of immune response, vascular transformation, as well as angiotensin II and angiotensin converting enzyme-2. Further prospective studies of potential predictors of severe pneumonia will enable using marker molecules in a comprehensive clinical and laboratory diagnosis for early prediction of the hospitalized patient’s condition and expected outcome.

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Section: маркеры иммунного ответа организмаunclassified

Potential predictors of severe course and outcome of community-acquired pneumonia

Volchkova¹,

Titova

Кузубова

et al. 2023

Pulʹmonologiâ (Mosk.)

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Aerobic glycolysis of bronchial epithelial cells rewires Mycoplasma pneumoniae pneumonia and promotes bacterial elimination

He,

Xiu,

Chen

et al. 2024

Infect Immun

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The immune response to Mycoplasma pneumoniae infection plays a key role in clinical symptoms. Previous investigations focused on the pro-inflammatory effects of leukocytes and the pivotal role of epithelial cell metabolic status in finely modulating the inflammatory response have been neglected. Herein, we examined how glycolysis in airway epithelial cells is affected by M. pneumoniae infection in an in vitro model. Additionally, we investigated the contribution of ATP to pulmonary inflammation. Metabolic analysis revealed a marked metabolic shift in bronchial epithelial cells during M. pneumoniae infection, characterized by increased glucose uptake, enhanced aerobic glycolysis, and augmented ATP synthesis. Notably, these metabolic alterations are orchestrated by adaptor proteins, MyD88 and TRAM. The resulting synthesized ATP is released into the extracellular milieu via vesicular exocytosis and pannexin protein channels, leading to a substantial increase in extracellular ATP levels. The conditioned medium supernatant from M. pneumoniae -infected epithelial cells enhances the secretion of both interleukin (IL)-1β and IL-18 by peripheral blood mononuclear cells, partially mediated by the P2X7 purine receptor (P2X7R). In vivo experiments confirm that addition of a conditioned medium exacerbates pulmonary inflammation, which can be attenuated by pre-treatment with a P2X7R inhibitor. Collectively, these findings highlight the significance of airway epithelial aerobic glycolysis in enhancing the pulmonary inflammatory response and aiding pathogen clearance.

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Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells

Cited by 2 publications

References 61 publications

Potential predictors of severe course and outcome of community-acquired pneumonia

Potential predictors of severe course and outcome of community-acquired pneumonia

Aerobic glycolysis of bronchial epithelial cells rewires Mycoplasma pneumoniae pneumonia and promotes bacterial elimination

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