<i>Mycobacterium tuberculosis</i>Infection Complicated by Eales Disease with Peripheral Neuropathy

McCaughan, Frank; Holmes, Alison; Lynn, William; Friedland, Jon S.

doi:10.1086/342888

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Neurological causes are the most common extra-ocular manifestations. These include myelitis or myelopathy (5,7–9), stroke (5,10–12), internuclear ophthalmoplegia (13), ataxia (9), peripheral neuropathy (14) and cranial nerve paralysis (15). The neurological manifestations of ED are usually responsive to steroids and the ophthalmological symptoms precede neurological symptoms in more than 50% of patients by a period of six months to 10 years (5).…”

Section: Discussionmentioning

confidence: 99%

“…In the only series that described post-mortem findings for nine patients with ED with central nervous system involvement, ED was described as an inflammatory venopathy with perivenular demyelination (14,18). Similarly, in a report of a 38-year-old woman with ED who had bilateral stroke, the angiography revealed beading of the Sylvian arteries (11).…”

Section: Discussionmentioning

confidence: 99%

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Steroid-responsive painful ophthalmoplegia: Tolosa–Hunt syndrome, Eales disease, or both?

et al. 2016

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Introduction Tolosa-Hunt syndrome (THS) is one of the most common 'benign' causes of painful ophthalmoplegia. Diagnosis is based on clinical and imaging findings and the exclusion of other causes because there is no specific biomarker for the syndrome. Eales disease, an idiopathic inflammatory venous disease that primarily affects the eye, can also affect the central (as stroke or myelitis) and peripheral nervous system. Case report We report the case of a 32-year-old woman with a subacute left ophthalmoplegia and evidence of a gadolinium-enhanced lesion suggesting an inflammatory granuloma that resolved within 48 hours after treatment with steroids. A diagnosis of THS was considered at this time. On a follow-up ophthalmological examination, a diagnosis of Eales disease with involvement of the left eye was made. The patient was treated successfully. Conclusion Eales disease could be a cause of painful ophthalmoplegia and may mimic THS. Long-term follow-up of patients diagnosed with THS may be necessary to exclude other diagnoses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Steroid-responsive painful ophthalmoplegia: Tolosa–Hunt syndrome, Eales disease, or both?

et al. 2016

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“…Mononeuropathy multiplex can be caused by vasculitis, sarcoidosis, malignancy, amyloidosis, immunization, trauma, and infection. Peripheral nerve injury associated with M. tuberculosis infection before anti‐tuberculosis treatment is rare; fewer than 10 cases have been reported [2–5]. The possible mechanisms for tuberculosis‐associated peripheral neuropathy include an immune‐mediated process, direct invasion, vasculitis, compression, a meningitic reaction, or the toxic effects of anti‐tuberculosis therapy [4].…”

Section: Discussionmentioning

confidence: 99%

“…There are many causes for this disorder, but vasculitis has been the most commonly reported [1]. Except the occurrence of side‐effects to anti‐tuberculosis drugs, peripheral nerve injury related to Mycobacterium tuberculosis is rarely reported [2–5]. Chylothorax is a condition in which chyle leaks into the pleural cavity from the thoracic duct.…”

Section: Introductionmentioning

confidence: 99%

Mononeuropathy multiplex and chylothorax as earlier manifestations of pulmonary tuberculosis

Chen

Cheng

Lin

et al. 2005

Journal of Internal Medicine

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Mononeuropathy multiplex (MNM) and chylothorax are rare clinical disorders. The concurrence of these two disorders with Mycobacterium tuberculosis infection has not been reported. We herein report a patient who was initially diagnosed with fever of unknown origin and MNM, and then developed chylothorax. Pulmonary tuberculosis was proved 1 month after chylothorax appeared. With low-dose prednisolone 15 mg day )1 and anti-tuberculosis drugs, all these disorders completely resolved 1 year later.

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“…The most prevalent etiological theory is hypersensitivity to tuberculinprotein that develops after exposure to Mycobacterium tuberculosis [5]. However, cases of active tuberculosis infection with concurrent Eales' disease are unusual [6]. Complications of Eales' disease include tractional retinal detachment, cataract, rubeosis iridis and phthisis bulbi.…”

Section: Introductionmentioning

confidence: 99%

Advanced Eales’ Disease With Neovascular Glaucoma at First Presentation

Alfayyadh¹,

AlAbdulhadi

Almubarak³

2021

Cureus

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Eales' disease is an idiopathic vasculitis that affects the peripheral retina. It is characterized by recurrent vitreous hemorrhage as a complication of retinal neovascularization. It is more prevalent in India and affects young males. Here, we present a patient with neovascular glaucoma as a rare first presentation of Eales' disease. This is a 24-year-old Indian male, who complained of a sudden decrease in vision in the left eye over less than 24 hours, along with frontal headache and eye pain for the last three weeks. Ocular examination revealed peripheral retinal ischemia in the right eye, very high intraocular pressure, rubeosis iridis, vitreous hemorrhage and extensive retinal ischemia in the left eye, vascular sheathing and neovascularization in both eyes. The purified protein derivative skin test was positive. The patient was managed with anti-glaucoma, intravitreal anti-vascular endothelial growth factor and laser photocoagulation. Systemic steroids and anti-tuberculous therapy were also initiated. Neovascular glaucoma is an infrequent complication of Eales' disease. However, the lack of early detection of the disease in the early stages might lead to such serious complications.

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Mycobacterium tuberculosisInfection Complicated by Eales Disease with Peripheral Neuropathy

Cited by 6 publications

References 8 publications

Steroid-responsive painful ophthalmoplegia: Tolosa–Hunt syndrome, Eales disease, or both?

Steroid-responsive painful ophthalmoplegia: Tolosa–Hunt syndrome, Eales disease, or both?

Mononeuropathy multiplex and chylothorax as earlier manifestations of pulmonary tuberculosis

Advanced Eales’ Disease With Neovascular Glaucoma at First Presentation

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