Mycobacterium tuberculosisESX-T7SS impacts the 3D architecture of tuberculous lesion in susceptible mice
Caroline G.G. Beltran,
Jurgen Kriel,
Stefan M. Botha
et al.
Abstract:Tuberculosis (TB) is characterized by the formation of heterogenous, immune-rich granulomas present in various forms in the lungs. Both host and pathogen contribute to this heterogeneity however the molecular and cellular drivers of within-host granuloma heterogeneity remain to be fully elucidated. This knowledge gap is due to a lack of experimental approaches that can fully capture the complex dynamics of the lung architecture, dynamics of host-pathogen interplay and pathogenesis. Here, we developed an approa… Show more
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