<i>Mycobacterium marinum</i>
            Infections in Fish and Humans in Israel

Ucko, Michal; Colorni, A.

doi:10.1128/jcm.43.2.892-895.2005

Cited by 72 publications

(56 citation statements)

References 18 publications

(9 reference statements)

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“…Subsequent analysis of the strain showed that it too contained a pMUM-like plasmid with the mycolactone mls genes and that it made yet another mycolactone, called mycolactone F (26). In the same study, a cluster of M. marinum strains that had been isolated from diseased fish in the Red and Mediterranean Seas (38) were also positive for mls gene sequences, and they too produced mycolactone F (26). One of these strains (DL240490) shared identical hsp65 gene sequences with M. pseudoshottsii and another fish pathogen, Mycobacterium seriolae (28).…”

mentioning

confidence: 94%

Evolution of Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria from a Common Mycobacterium marinum Progenitor

et al. 2007

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It had been assumed that production of the cytotoxic polyketide mycolactone was strictly associated with Mycobacterium ulcerans, the causative agent of Buruli ulcer. However, a recent study has uncovered a broader distribution of mycolactone-producing mycobacteria (MPM) that includes mycobacteria cultured from diseased fish and frogs in the United States and from diseased fish in the Red and Mediterranean Seas. All of these mycobacteria contain versions of the M. ulcerans pMUM plasmid, produce mycolactones, and show a high degree of genetic relatedness to both M. ulcerans and Mycobacterium marinum. Here, we show by multiple genetic methods, including multilocus sequence analysis and DNA-DNA hybridization, that all MPM have evolved from a common M. marinum progenitor to form a genetically cohesive group among a more diverse assemblage of M. marinum strains. Like M. ulcerans, the fish and frog MPM show multiple copies of the insertion sequence IS2404. Comparisons of pMUM and chromosomal gene sequences demonstrate that plasmid acquisition and the subsequent ability to produce mycolactone were probably the key drivers of speciation. Ongoing evolution among MPM has since produced at least two genetically distinct ecotypes that can be broadly divided into those typically causing disease in ectotherms (but also having a high zoonotic potential) and those causing disease in endotherms, such as humans.

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mentioning

confidence: 94%

Evolution of Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria from a Common Mycobacterium marinum Progenitor

et al. 2007

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“…Although the species in sub-cluster A3 were caused human pulmonary disease, the prevalence of these opportunistic infections was very low and also these infections are from animal sources. Similarly M. marinum causing infection in fishes [48] and M. liflandii causing infection in frogs [49,50] were grouped in sub-cluster A2. Exception to the host dependency clustering were species viz, M. ulcerans, causing buruli ulcers in humans and it was clustered in sub-cluster A2.…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Mycobacterial Ribonucleotide Reductase (RNR) and its Implication as a Novel Drug Target

Mohanty¹,

Naaz²

2015

Bioenergetics

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The genus Mycobacterium consists of both pathogenic and non-pathogenic species. The emergence of MDR and XDR tuberculosis and opportunistic infections by non tuberculous mycobacterium in immunosuppressive persons are major concern now a days. The aim of the study was to characterize ribonucleotide reductase (RNR) of Mycobacterium species to produce information about the evolution of the gene which could further be used in targeting RNR as a novel drug target. Here we were analyzed RNR of 23 mycobacterial species. The sequence length of RNR region is about 975 bp. Out of 975 characters 625 (64.10%) are conserved sites (monomorphic) and 350 (35.89%) are variable sites (polymorphic). The total nucleotide diversity (π) is=0.120114 (12.011%). The RNR phylogeny approach in Mycobacterium species provides evidence of several evolutionary lineages evolving from the ancestral polymorphism and fixed in the descendant population. Species of mycobacteria causing tuberculosis or respiratory infection in humans have specific patterns of allele distribution in different motifs, which differentiate them from other opportunistic mycobacterial species. Molecular analysis and structural motif analysis of RNR suggests the occurrence of host-mediated genetic differentiation in mycobacterial species, which requires further wet lab investigations.

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“…Recently, the number of reported cases of infection caused by non-tuberculous mycobacterium has increased, and the clinical importance of these organisms is growing (8,19,31). The identification of M. peregrinum in fish is significant because it can be a human pathogen that is responsible for infections commonly associated with human skin and soft tissues (19), bacteriaemia (14,27), pneumonia (16), and tonsillar abscessus (26).…”

Section: Discussionmentioning

confidence: 99%

“…Mycobacterium fortuitum complex (M. fortuitum, M. peregrinum type 1, and M. peregrinum type 2), M. avium complex (M. avium, M. intracellulare), M. chelonae-M. abscessus complex (M. abscessus and M. chelonae), M. scrofulaceum, M. kansasii, and M. marinum are common in the environment (9,10,11,17). It is increasingly recognised that humans may be infected or colonised with non-tuberculous mycobacteria, "atypical mycobacteria" or "mycobacteria other than M. tuberculosis" (MOTT) (24,31).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and antimicrobial susceptibility of Mycobacterium peregrinum in ornamental fish

Guz

Grądzki

Krajewska

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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Mycobacterium marinum Infections in Fish and Humans in Israel

Cited by 72 publications

References 18 publications

Evolution of Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria from a Common Mycobacterium marinum Progenitor

Evolution of Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria from a Common Mycobacterium marinum Progenitor

Molecular Characterization of Mycobacterial Ribonucleotide Reductase (RNR) and its Implication as a Novel Drug Target

Occurrence and antimicrobial susceptibility of Mycobacterium peregrinum in ornamental fish

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