<i>Mycobacterium fortuitum</i>: an iatrogenic cause of soft tissue infection in surgery

Muthusami, John C.; Vyas, Frederick L; Mukundan, U; Jesudason, Mark Ranjan; Govil, Sanjay; Jesudason, S. R. Banerjee

doi:10.1111/j.1445-1433.2004.03018.x

Cited by 42 publications

(41 citation statements)

References 35 publications

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“…M.fortuitum responds to antibiotics like amikacin, quinolones, doxycycline and sulphamethaxole. As per latest studies clarithromycin, cefoxitin and imipenem were useful for treatment against RGM [17][18][19]. Almost all the patients in our study were cured with a combined approach of drainage and clarithromycin based combination therapy.…”

Section: Discussionmentioning

confidence: 71%

Surgical Site Infections Due to Rapidly Growing Mycobacteria in Puducherry, India

Kannaiyan

Ragunathan

Sakthivel

et al. 2015

JCDR

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Background: Rapidly growing Mycobacteria are increasingly recognized, nowadays as an important pathogen that can cause wide range of clinical syndromes in humans. We herein describe unrelated cases of surgical site infection caused by Rapidly growing Mycobacteria (RGM), seen during a period of 12 months. Materials and Methods: Nineteen patients underwent operationsby different surgical teams located in diverse sections of Tamil Nadu, Pondicherry, Karnataka, India. All patients presented with painful, draining subcutaneous nodules at the infection sites. Purulent material specimens were sent to the microbiology laboratory. Gram stain and Ziehl-Neelsen staining methods were used for direct examination. Culture media included blood agar, chocolate agar, MacConkey agar, Sabourauds agar and Lowenstein-Jensen medium for Mycobacteria. Isolated microorganisms were identified and further tested for antimicrobial susceptibility by standard microbiologic procedures.

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Section: Discussionmentioning

confidence: 71%

Surgical Site Infections Due to Rapidly Growing Mycobacteria in Puducherry, India

Kannaiyan

Ragunathan

Sakthivel

et al. 2015

JCDR

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“…Infections with atypical mycobacteria have been primarily reported after laparoscopic procedures [9,10]. This is because, unlike open surgery, the instruments used here have a layer of insulation that restricts the use of the autoclave in the sterilization process.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Management of Atypical Mycobacterial Infection after Laparoscopic Surgery

2010

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Atypical mycobacterial infections at the laparoscopic port site are a frequent problem encountered in patients undergoing laparoscopic surgery. In this study we concentrate on the clinical diagnosis, management and prevention of this problem. In this series we assess 19 patients presenting with port hole infections after laparoscopic surgery and were treated with a combination of oral clarithromycin and ciprofloxacin. Seven patients who had persistent nodules were given injections of amikacin directly into the infection foci along with standard oral therapy. Most of the patients treated with standard oral therapy for 28 days showed recovery. The patients with persistent nodules 4 weeks after completion of therapy were treated with injections of amikacin directly into the nodule which lead to resolution of symptoms. For prevention of infection, proper sterilization and storage of instruments is recommended. Laparoscopic port hole infections is a preventable problem and can also be treated by nonsurgical method.

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“…18 There has also been a report from our institution on the isolation of M. fortuitum from surgical specimens of patients with post operative wound infections, injection abscesses, skin and soft tissue infections. 15 Although there are many reports from India, the exact disease burden of NTM infections still remains unclear in India. These infections are under diagnosed in many laboratories due to lack of facilities and expertise.…”

Section: Discussionmentioning

confidence: 99%

Non tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital in South India

Mv¹,

Gladstone²

2005

Indian J Med Microbiol

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Purpose: This is a retrospective analysis of the isolation rates of nontuberculous mycobacteria (NTM) from various clinical specimens and their antimicrobial susceptibility patterns. Methods: All NTM isolated between 1999 and 2004 at Christian Medical College, Vellore, South India, were identified with various biochemical tests. Antimicrobial susceptibility test for all NTM was performed by standard methods. Results: A total of 32,084 specimens were received for culture, of which 4473 (13.9%) grew acid fast bacilli (AFB). Four thousand three hundred (96.1%) of the AFB were M. tuberculosis while 173 (3.9%) were NTM. Of the 173 NTM, 115 (66.5%) were identified to the species level. Pus, biopsy specimens and sputum specimens yielded most of the NTM of which M. chelonae (46%) and M. fortuitum (41%) accounted for majority of them. M. chelonae and M. fortuitum, showed highest susceptibility to amikacin (99.2%). NTM were repeatedly isolated from seven sputum specimens, 15 biopsy and pus specimens, two CSF and two blood cultures. Six were isolated from patients with AIDS and five from post transplant patients. Conclusions: The isolation of NTM from various clinical specimens is reported in this study to highlight the associated diseases and therapeutic options in these infections. 1 NTM comprising of over 95 species are naturally seen as saprophytes 2 but are known to cause four different categories of infections in humans such as, i) pulmonary infections resembling tuberculosis, ii) extra pulmonary infections affecting lymph nodes, skin and soft tissue, iii) multifocal disseminated infections and iv) infections in immunocompromised individuals such as AIDS and transplant patients.3 The growing population of HIV infected individuals and other immunosuppessed / immunocompromised patients coupled with better diagnostic techniques has led to an increase in the number of NTM being reported in human infections in recent years. 4 NTM produce infections more commonly in the presence of predisposing factors / underlying diseases; they are also notably resistant to commonly used antitubercular drugs. These factors augment morbidity and limit therapeutic options in such infections. NTM have been reported world wide with varying frequencies, 5-8 while in India isolation rates are between 0.7% and 34%. 9 We have reviewed the isolation rates of NTM from various clinical specimens over a period of six years at the department of Clinical Microbiology, Christian Medical College, Vellore -South India. Through this study we wish to emphasize the need to look for NTM in various clinical specimens. Materials and MethodsThis study includes the isolation of NTM from all clinical specimens from suspected pulmonary and extra pulmonary tuberculosis received between 1999 and 2004. Early morning well coughed out sputum specimens, broncho alveolar lavage, bronchial wash and endotracheal aspirate specimens were received from patients with clinical and radiological findings suggestive of pulmonary tuberculosis. From children and patients fro...

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Mycobacterium fortuitum: an iatrogenic cause of soft tissue infection in surgery

Cited by 42 publications

References 35 publications

Surgical Site Infections Due to Rapidly Growing Mycobacteria in Puducherry, India

Surgical Site Infections Due to Rapidly Growing Mycobacteria in Puducherry, India

Diagnosis and Management of Atypical Mycobacterial Infection after Laparoscopic Surgery

Non tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital in South India

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