<i>Mycobacterium chelonae</i>Abscesses Associated with Biomesotherapy, Australia, 2008

Ivan, Mihaela; Dancer, Craig; Koehler, Ann P.; Hobby, Michaela; Lease, Chris

doi:10.3201/eid1909.120898

Cited by 11 publications

(4 citation statements)

References 12 publications

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“…1). 25,35,39–66 A 43.3% majority of articles (13 of 30) were published from South America. The next 36.7% of articles (11 of 30) were published from Europe.…”

Section: Resultsmentioning

confidence: 99%

Clinical features of mesotherapy-associated non-tuberculous mycobacterial infections: A systematic review

Singsing,

Duncan,

Vachon

et al. 2022

International Journal of Women’s Dermatology

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Background: Cutaneous infections from non-tuberculous mycobacteria (NTM) are a well-documented but poorly characterized adverse event following mesotherapy injections. Objective: This study aims to consolidate the available literature to characterize demographic and clinical features of mesotherapy-associated NTM infections. Methods: Using PRISMA guidelines, a systematic review of PubMed, Scopus, and Embase databases was undertaken for articles reporting cases of NTM skin infections following mesotherapy. Data were analyzed using Microsoft Excel. Results: Of 1966 search results, 30 articles (N = 423 patients) met inclusion criteria. Studies were largely from South America, and patients were mostly women aged 16-55 with NTM infections arising in the abdomen, buttocks, or thighs. Nearly all patients developed multiple, well-localized lesions without systemic symptoms. Effect summary by meta-analysis revealed most infections resolved after antibiotic therapy, though many patients required multiple antibiotic courses and/or agents to resolve infection. Infections often took weeks to resolve and were complicated by post-treatment scarring. Limitations: The main limitation of this study was the heterogeneity and lack of consistency between case reports. Conclusion: Cutaneous NTM infections associated with mesotherapy generally occur in women of childbearing age, arise from injections contaminated by the environment, and are often complicated by scarring/poor cosmesis and prolonged treatment course.

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“…1). 25,35,39–66 A 43.3% majority of articles (13 of 30) were published from South America. The next 36.7% of articles (11 of 30) were published from Europe.…”

Section: Resultsmentioning

confidence: 99%

Clinical features of mesotherapy-associated non-tuberculous mycobacterial infections: A systematic review

Singsing,

Duncan,

Vachon

et al. 2022

International Journal of Women’s Dermatology

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“…The most common manifestation of extrapulmonary NTM disease is skin or soft-tissue infection. These infections usually develop after traumatic injury, cosmetic procedures, or surgery, which can expose wounds to soil, water, or medical devices contaminated with environmental mycobacteria [16171819202122]. Previous report has suggested that incidence of cutaneous NTM infection has increased nearly 3-fold during the past 30 years [12].…”

Section: Skin and Soft Tissue Infectionsmentioning

confidence: 99%

“…Rapidly growing mycobacteria (RGM), including M. abscessus complex, M. chelonae , and M. fortuitum , are increasingly encountered species causing skin and soft tissue infections. Acupuncture, contaminated ultrasound gel, mesotherapy, and injection of dermal fillers have been reported as the causes of large outbreaks in the last 2 decades [16171819202122]. M. abscessus complex and M. chelonae are frequently related to long-term steroid treatment, immunosuppression, or concurrent illnesses [21].…”

Section: Skin and Soft Tissue Infectionsmentioning

confidence: 99%

Treatment of Extrapulmonary Nontuberculous Mycobacterial Diseases

2019

Infect Chemother

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Nontuberculous mycobacteria (NTM) diseases mainly manifest as pulmonary illnesses, but 20 -30% of NTM isolates originate from extrapulmonary diseases. These diseases cause a variety of clinical syndromes, including skin and soft-tissue infections, musculoskeletal infections, lymphadenitis, and disseminated disease. In skin and soft-tissue infections, musculoskeletal infections, prolonged treatment with combinations of antibiotics is effective in the treatment of NTM diseases, with surgery as an important complementary tool. The recommended duration of therapy for skin and soft-tissue infection is usually 2 – 4 months for mild disease and 6 months for severe disease, while treatment of musculoskeletal NTM disease usually requires at least 6 - 12 months. Management options of NTM lymphadenitis include surgical intervention, medical therapy, or observation. Treatment of disseminated NTM disease generally requires 6 to 12 months after immune restoration. However, despite a considerable increase in knowledge about NTM diseases, determining optimal treatment approaches remains a complex and challenging task.

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“…Recent outbreaks have been associated with contaminated ultrasound gel, injection of dermal fillers, mesotherapy, and acupuncture. [47][48][49][50][51] M. abscessus complex, M. chelonae, and M. fortuitum are most commonly encountered. Each of these species has been responsible for a significant outbreak of cutaneous disease in the last two decades.…”

Section: Cutaneous Infectionmentioning

confidence: 99%

Management of Extrapulmonary Nontuberculous Mycobacterial Infections

Holt

Kasperbauer

2018

Semin Respir Crit Care Med

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Extrapulmonary disease occurs in a minority of nontuberculous mycobacterial (NTM) infections. The pattern of disease tends to be multifocal in immunocompromised individuals and localized in the immunocompetent. There is increasing recognition of disseminated infection, as a complication of cardiac surgery, and focal infections due to rapidly growing mycobacteria. Microbiologic diagnosis requires detection of NTM in blood or tissue samples by microscopy, culture, or molecular methods. Management of extrapulmonary NTM infection requires prolonged, targeted multiple-drug therapy and, in some cases, aggressive surgical intervention. The optimal treatment approach is often unknown. Despite combined medical and surgical therapy, outcomes may be poor. A high degree of clinical suspicion and early diagnosis are required to maximize chances of a positive outcome.

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Mycobacterium chelonaeAbscesses Associated with Biomesotherapy, Australia, 2008

Cited by 11 publications

References 12 publications

Clinical features of mesotherapy-associated non-tuberculous mycobacterial infections: A systematic review

Clinical features of mesotherapy-associated non-tuberculous mycobacterial infections: A systematic review

Treatment of Extrapulmonary Nontuberculous Mycobacterial Diseases

Management of Extrapulmonary Nontuberculous Mycobacterial Infections

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