2009
DOI: 10.4049/jimmunol.0900365
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Abstract: Macrophages have important roles in both lipid metabolism and inflammation and are central to immunity to intracellular pathogens. Foam-like, lipid-laden macrophages are present during the course of mycobacterial infection and have recently been implicated in mycobacterial pathogenesis. In this study, we analyzed the molecular mechanisms underlying the formation of macrophage lipid bodies (lipid droplets) during Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, focusing on the role of the lipid-ac… Show more

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Cited by 153 publications
(218 citation statements)
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References 55 publications
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“…PPAR␥ and TR4 provoke anti-inflammatory and pro-mycobacterium properties of macrophages (16,17,25), whereas vitamin D receptor and LXRs on the other hand have anti-inflammatory but anti-infective or bactericidal properties (39,40). Similarly, we observe that Rev-erb␣ facilitates M. tuberculosis clearance as an effect of its role in reducing IL10 production (Fig.…”
Section: Discussionsupporting
confidence: 50%
“…PPAR␥ and TR4 provoke anti-inflammatory and pro-mycobacterium properties of macrophages (16,17,25), whereas vitamin D receptor and LXRs on the other hand have anti-inflammatory but anti-infective or bactericidal properties (39,40). Similarly, we observe that Rev-erb␣ facilitates M. tuberculosis clearance as an effect of its role in reducing IL10 production (Fig.…”
Section: Discussionsupporting
confidence: 50%
“…1D) were also analyzed. Two-way ANOVA revealed significant effects of time (F time(4,30) =16.29, P<0.0001) and infection/treatment (F infection(2,30) =57.64, P<0.0001) on IL-6 production, as well as an interaction between them (F interaction (8,30) =4.46, P<0.01). Similarly, the levels of TNF-α were also significantly affected by time (F time(4,30) =25.92, P<0.0001) and infection/treatment (F infection(2,30) =3.94, P<0.05); however, no significant effect of time-infection interaction was detected (F interaction (8,30) =2.95, P=0.07).…”
Section: Pparγ Expression P38 Phosphorylation and Cytokine Productiomentioning
confidence: 99%
“…3A). Two-way ANOVA revealed a significant effect of TLR2 knockdown (F TLR2-siRNA (1,8) =70.4, P<0.0001) and P19 treatment (F P19 (1,8) =23.3, P<0.01) on PPARγ mRNA expression, as well as an interaction between them (F interaction (1,8) =21.8, P<0.01) (Fig. 3B).…”
Section: P19-induced Pparγ Expression P38 Phosphorylation and Cytokimentioning
confidence: 99%
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“…Há evidências que confirmam a hipótese de que PGE 2 endógena derivada de CL modula a resposta inibitória em macrófagos infectados por micobactérias [37,99] . Assim, a inibição de CL em macrófagos não só leva à diminuição destas organelas, mas também aumenta a morte celular dos macrófagos infectados com micobactérias, dando suporte a hipótese de que os CLs podem ter implicações na patogênese da infecção por micobactéria [100] . [102] .…”
Section: Corpúsculos Lipídicos E Sua Inibição Farmacológicaunclassified