<i>Mycobacterium avium-</i>complex pericarditis: a case of unmasking immune reconstitution inflammatory syndrome

Babu, Tara M; Laguio, Maryrose; Luque, Amneris E.; Larppanichpoonphol, Panupong

doi:10.1177/0956462413495821

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…MAC pericarditis has been reported mainly in patients with HIV infection [6,7], but immunocompetent subject can also be infected [8,9]. To the best of our knowledge, this is the first case report of MAC pericarditis in a HD patient.…”

Section: Discussionmentioning

confidence: 85%

A hemodialysis patient with Mycobacterium avium complex pericarditis in which remarkable presepsin elevation was not accompanied by procalcitonin elevation

Shiota¹

2020

Ren Replace Ther

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Background: The application of presepsin for diagnosing infections in hemodialysis (HD) patients has not been confirmed yet. In addition, whether presepsin can detect atypical mycobacterial infection or not remains unknown. Case presentation: We describe the case of a 66-year-old male HD patient with pericardial tamponade. Mycobacterium avium complex (MAC) was identified from a culture of pericardial effusion. The patient showed a clinical improvement after approximately 1 year without the administration of antibiotics. Remarkably, high plasma presepsin values were observed without an increase in serum procalcitonin values. The patient's presepsin values decreased after the treatment of MAC induced pericarditis. Conclusions: We found a HD patient with mycobacterium avium complex pericarditis with remarkable presepsin elevation unaccompanied by PCT elevation.

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Section: Discussionmentioning

confidence: 85%

A hemodialysis patient with Mycobacterium avium complex pericarditis in which remarkable presepsin elevation was not accompanied by procalcitonin elevation

Shiota¹

2020

Ren Replace Ther

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“…The incidence of disseminated MAC infection presenting as unmasking IRIS is 3.5% among patients who are initiated with ART with a base-line CD4 cell count of <100 cells/μL [3]. MAC-IRIS commonly involves the lymph nodes, bone marrow, and gastrointestinal tract [[4], [5], [6]]. In this case, MAC-IRIS could have developed on the 39 th day of the ART treatment, when the fever continued for a week.…”

Section: Discussionmentioning

confidence: 99%

Large abscess formed in the abdominal wall by Mycobacterium avium complex: A case of unmasking immune reconstitution inflammatory syndrome

Yanagisawa

Takeuchi

Nakamura

et al. 2019

IDCases

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Immune reconstitution inflammatory syndrome (IRIS) is a clinical entity with a broad presentation that is complicated in patients with acquired immunodeficiency syndrome after initiating antiretroviral therapy. A 51-year-old Japanese man was diagnosed with disseminated Mycobacterium avium complex (MAC) infection presenting as unmasking IRIS, which formed a large abscess in the patient’s abdominal wall. MAC-IRIS commonly involves the lymph nodes, bone marrow, and gastrointestinal tract. To our knowledge, this is the first case report of an abdominal wall abscess caused by MAC-IRIS.

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Immune reconstitution inflammatory syndrome associated with bacterial infections

Lagier

Raoult

2014

Expert Opinion on Drug Safety

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IRIS is mainly observed during infections (viral, fungal or bacterial) which involve inefficient macrophages for the clearance of bacteria, namely Actinobacteria such as Mycobacterium leprae, M. tuberculosis and Tropheryma whipplei. The restoration of macrophage competence after ART or antibiotic initiation results from a complex mechanism, probably involving a sudden and violent immune reaction with a cytokine storm, such as TNF-α and IFN-γ. This overreaction might be controlled using corticosteroids and thalidomide.

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Mycobacterium avium-complex pericarditis: a case of unmasking immune reconstitution inflammatory syndrome

Cited by 3 publications

References 6 publications

A hemodialysis patient with Mycobacterium avium complex pericarditis in which remarkable presepsin elevation was not accompanied by procalcitonin elevation

A hemodialysis patient with Mycobacterium avium complex pericarditis in which remarkable presepsin elevation was not accompanied by procalcitonin elevation

Large abscess formed in the abdominal wall by Mycobacterium avium complex: A case of unmasking immune reconstitution inflammatory syndrome

Immune reconstitution inflammatory syndrome associated with bacterial infections

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