<i>Mycobacterium abscessus</i>Scleritis Following Intravitreous Injection of Bevacizumab

Golen, Jeffrey; Espana, Edgar M.; Margo, Curtis E.

doi:10.1001/jamaophthalmol.2013.2138

Cited by 7 publications

(6 citation statements)

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“…There are eighteen cases of NTM scleritis reported in the literature [ 134 – 143 ]. Almost all cases were directly preceded by an intervention (17/18 eyes, 94.4%).…”

Section: Results Specific To Location Of Infectionmentioning

confidence: 99%

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Nontuberculous Mycobacterial Ocular Infections: A Systematic Review of the Literature

Kheir

Sheheitli

Fattah

et al. 2015

BioMed Research International

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Nontuberculous or atypical mycobacterial ocular infections have been increasing in prevalence over the past few decades. They are known to cause periocular, adnexal, ocular surface and intraocular infections and are often recalcitrant to medical therapy. These infections can potentially cause detrimental outcomes, in part due to a delay in diagnosis. We review 174 case reports and series on nontuberculous mycobacterial (NTM) ocular infections and discuss etiology, microbiology, risk factors, diagnosis, clinical presentation, and treatment of these infections. History of interventions, trauma, foreign bodies, implants, contact lenses, and steroids are linked to NTM ocular infections. Steroid use may prolong the duration of the infection and cause poorer visual outcomes. Early diagnosis and initiation of treatment with multiple antibiotics are necessary to achieve the best visual outcome.

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“…There are eighteen cases of NTM scleritis reported in the literature [ 134 – 143 ]. Almost all cases were directly preceded by an intervention (17/18 eyes, 94.4%).…”

Section: Results Specific To Location Of Infectionmentioning

confidence: 99%

“…Diagnosis of NTM scleritis was made through samples obtained from scleral biopsies of abscesses and nodules sent for culture. In 1 case, the etiological agent was confirmed by 116S rRNA sequencing [ 134 ]. Explanted scleral buckles were also used to isolate NTM.…”

Section: Results Specific To Location Of Infectionmentioning

confidence: 99%

Nontuberculous Mycobacterial Ocular Infections: A Systematic Review of the Literature

Kheir

Sheheitli

Fattah

et al. 2015

BioMed Research International

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“…Only a few cases of infectious scleritis after intravitreal therapy have been reported. 3,4 In our department, all intravitreal injections are performed in a clean room, sterile syringes of aflibercept are prepared in the hospital pharmacy, surgical mask and sterile gloves are used, 5% povidone-iodine is applied on the eyelids and conjunctiva, a lid speculum is placed, and no topical antibiotics are used after the injection. Because it has only been an isolated case and not an outbreak, there is no reason to think that it was associated with poor injection technique.…”

Section: Discussionmentioning

confidence: 99%

Fungal Necrotizing Scleritis After Intravitreal Injection Therapy

Hernández-Pons

Ortiz-Seller

López-Cruz

et al. 2021

Cornea

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Purpose: To report a case of infectious necrotizing scleritis secondary to Aspergillus terreus after intravitreal injection therapy.Methods: This is a case report with literature review.Results: A 98-year-old woman receiving intravitreal aflibercept injections for neovascular age-related macular degeneration in the left eye presented with severe pain, redness, and purulent discharge at the injection site. She was initially treated with topical fortified antibiotics, and clinical improvement was achieved, although microbial cultures showed negative results. Two months later, she presented with severe ocular pain and was diagnosed with anterior necrotizing scleritis. Scleral scrapings were collected for cultures, and intensive topical antibiotic therapy was reintroduced. Evaluation for autoimmune etiology and microbiological testing showed negative results. Because of the progression of the scleral necrotic area, empirical therapy with topical voriconazole was initiated, and surgical debridement was performed. Finally, the culture was positive for A. terreus. The modified therapy consisted of topical voriconazole and oral voriconazole for 3 months with an excellent clinical outcome. Conclusions:To our knowledge, this is the first case of fungal necrotizing scleritis secondary to intravitreal injection. Diagnosis was delayed due to its chronic clinical course and the slow fungal growth in culture media, but the combined medical and surgical approach resulted in a satisfactory outcome.

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“…Repeated injections lead to increased risk of retinal detachment, retinal tear, increased IOP, cataracts, and endophthalmitis [91][92][93][94][95] . There are also some rare complications, identified in recent years, such as RPE tear [96] , mycobacterium abscessus scleritis [97] , and corneal subepithelial infiltrates that are associated with the intravitreous injection of bevacizumab, because of an immune response to bevacizumab [98] . Eight of seventy-one eyes of patients with PDR developed ghost cell glaucoma after they underwent intravitreous injection of ranibizumab [99] .…”

Section: Complications and Vitreous Metabolic Disturbances With Laser...mentioning

confidence: 99%

Vitreous function and intervention of it with vitrectomy and other modalities

Zong¹,

Hui²

2022

Int J Ophthalmol

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The vitreous body, the largest intraocular component, plays a key role in eye development, refraction, cell barrier function, oxygen metabolism and the pathogenesis of assorted diseases. Age, refraction and systemic diseases can cause vitreous metabolic abnormalities. With the continuous development of vitrectomy techniques and equipment, vitreous injections and vitrectomies have increased over the recent decades. However, the normal oxygen tension gradient in the vitreous helps to protect the lens and anterior chamber angle from oxidative stress damage, whereas the increased vitreous oxygen tension around lens and the trabecular meshwork after vitrectomy. It may lead to postoperative nuclear cataract and increase the risk for glaucoma. As a conventional procedure, scleral buckling holds several advantages over vitrectomy in selected cases. This review raises concerns regarding the function of the vitreous and encourages conducting vitreous interventions prudently if it is possible.

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Mycobacterium abscessusScleritis Following Intravitreous Injection of Bevacizumab

Cited by 7 publications

References 0 publications

Nontuberculous Mycobacterial Ocular Infections: A Systematic Review of the Literature

Nontuberculous Mycobacterial Ocular Infections: A Systematic Review of the Literature

Fungal Necrotizing Scleritis After Intravitreal Injection Therapy

Vitreous function and intervention of it with vitrectomy and other modalities

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