<i>Mycobacterium abscessus</i>: insights from a bioinformatic perspective

Sur, Saubashya; Patra, Tanushree; Karmakar, Mistu; Banerjee, Anindita

doi:10.1080/1040841x.2022.2082268

Cited by 2 publications

(1 citation statement)

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“…Nocardia wallacei and Mycobacterium abscessus are both opportunistic pathogens. Only one third of infections caused by Nocardia wallacei happen in immunocompetent patients, while hosts infected by Mycobacterium abscessus are mostly immunocompromised( Johansen et al., 2020 ; Sur et al., 2022 ). Infections caused by these two bacteria alone are rare in immunocompetent patients, and the simultaneous infection is even rarer( Wei et al., 2021 ).…”

Section: Dissussionmentioning

confidence: 99%

A complicated infection by cutaneous Nocardia wallacei and pulmonary Mycobacterium abscessus in a Chinese immunocompetent patient: a case report

Qin,

Wang,

Zheng

et al. 2023

Front. Cell. Infect. Microbiol.

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Nocardiosis is an infectious disease caused by Nocardia that primarily affects immunocompromised hosts. Mycobacterium abscessus is a common opportunistic pathogen that causes disease in humans, including pulmonary and extrapulmonary infection. Nocardia spp. infection is uncommon, and infection with Nocardia wallacei and Mycobacterium abscessus is even rarer. A 59-year-old immunocompetent woman with risk factors for environmental exposure developed nocardiosis and presented to the hospital with a cough, shortness of breath, hemoptysis, and a back abscess. An enhanced computed tomography (CT) of the chest revealed partial destruction of the right lung, as well as consolidation of the right upper lobe. Rare pathogens N. wallacei and Mycobacterium abscessus were detected by metagenomic next-generation sequencing (mNGS) from abscess on the back and lung puncture tissue, respectively. She was treated with a combination of antibiotics and was finally discharged with a good prognosis. In this case, we present a patient who was successfully diagnosed with N. wallacei and Mycobacterium abscessus infection using mNGS. This importance of using mNGS in pathogen detection and the effective use of antibiotics in treating patients with long-term rare infections is highlighted in this report.

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Section: Dissussionmentioning

confidence: 99%