<i>Mycobacterium abscessus</i> Infection in Cystic Fibrosis

Cullen, Anne; Cannon, Carolyn L.; Mark, Eugene J.; Colin, Andrew A.

doi:10.1164/ajrccm.161.2.9903062

Cited by 153 publications

(108 citation statements)

References 20 publications

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“…The potential for patients with CF to have "indolent infection" by NTM, including M. abscessus, has previously been described in case series but is not well defined or universally accepted (8,12,14,31,32). Over the period of analysis, spanning ORIGINAL RESEARCH 1 year before and 3 years after the initial positive culture, we were unable to demonstrate a difference in FEV 1 decline between subjects with transient or persistent infection.…”

Section: Discussionmentioning

confidence: 67%

Clinical Significance of a First Positive Nontuberculous Mycobacteria Culture in Cystic Fibrosis

et al. 2014

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Rationale: Little is known about outcomes of infection with nontuberculous mycobacteria (NTM) in cystic fibrosis (CF) or about the significance of a positive NTM culture. Determining which patients are at risk for active NTM disease is clinically valuable.Objectives: To examine the clinical course of subjects with CF with an initial positive NTM culture and identify characteristics associated with active NTM disease.Methods: We performed a retrospective study of pediatric and adult subjects with CF with at least one positive NTM culture at the Colorado CF Center from 2000 to 2010.Measurements and Main Results: Mycobacterium avium complex was the first identified NTM in the majority of subjects (73%). The frequency of growing a second NTM species was 26% at 5 years. Clinical characteristics and distribution of NTM species between pediatric and adult subjects were similar except for differences in baseline FEV 1 (89% vs. 71%; P , 0.001) and coinfection with Pseudomonas aeruginosa (33% vs. 55%; P = 0.04). Over 60% of subjects had transient or persistent infection but not active NTM disease. Subjects who developed active NTM disease were distinguished from those with transient or persistent infection, respectively, by FEV 1 at the time of first positive NTM culture (72% vs. 84 or 86%; P = 0.02) and FEV 1 decline in the prior year (25.8%/yr vs. 20.7%/yr [P = 0.009] or 20.4%/yr [P = 0.001]). Conclusions:The majority of patients with CF with a first positive NTM culture do not progress to active disease. Lower lung function and accelerated lung function decline appear to be indicators of the significance of an initial positive NTM culture.

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Section: Discussionmentioning

confidence: 67%

Clinical Significance of a First Positive Nontuberculous Mycobacteria Culture in Cystic Fibrosis

et al. 2014

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“…Finally, another disturbing finding is the extremely heterogeneous clinical presentation of MABSC disease, extending from totally asymptomatic infection to fulminant forms in some patients, whether or not they had undergone transplantation [7][8][9][10]. This observation suggests a particular susceptibility to MABSC infection in some patients.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic MABSC infection is associated with a greater decline of lung function [6]. MABSC can cause severe pseudotuberculous lung disease [8], in some cases after following an indolent course for a number of years [9]. It may cause disseminated, sometimes fatal infections in lung transplant recipients [10,11].…”

mentioning

confidence: 99%

Inhaled therapies, azithromycin andMycobacterium abscessusin cystic fibrosis patients

Catherinot¹,

Roux²,

Vibet³

et al. 2012

Eur Respir J

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Cystic fibrosis (CF) patients are at particularly high risk of developing lung disease caused by Mycobacterium abscessus complex (MABSC). Over the last 10 years, changes in CF treatment, with increasing use of inhaled therapies and low-dose azithromycin, have been accompanied by an increase in the prevalence of MABSC infections in CF patients. There is therefore some concern about the role of new CF treatments in the emergence of MABSC infections.We addressed this issue by means of a case-control study including 30 MABSC-positive cases and 60 nontuberculous mycobacteria-negative CF controls matched for age, sex and centre. We also compared practices at the CF centres with the highest prevalence of MABSC with those at the other centres.No positive association was found between MABSC lung disease and the use of inhaled therapies or low-dose azithromycin in the 4 years preceding MABSC isolation. These treatments were not significantly more frequently used at the CF centres with the highest MABSC prevalence rates.In conclusion, there is no evidence for a link between M. abscessus complex lung disease and inhaled therapies or low-dose azithromycin in patients with CF.

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“…It is also a pulmonary pathogen in patients with cystic fibrosis (Cullen et al, 2000;Fauroux et al, 1997;Olivier et al, 2003;Sermet-Gaudelus et al, 2003). In some instances, isolation of M. abscessus from the sputum is not associated with progressive lung infection and may be the result of transient airway colonization (Griffith et al, 2007;Jönsson et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response

et al. 2011

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Mycobacterium abscessus is considered to be the most virulent of the rapidly growing mycobacteria. Generation of bacterial gene knockout mutants has been a useful tool for studying factors that contribute to virulence of pathogenic bacteria. Until recently, the optimal genetic approach to generation of M. abscessus gene knockout mutants was not clear. Based on the recent identification of genetic recombineering as the preferred approach, a M. abscessus mutant was generated in which the gene mmpL4b, critical to glycopeptidolipid synthesis, was deleted. Compared to the previously well-characterized parental strain 390S, the mmpL4B deletion mutant had lost sliding motility and the ability to form biofilm, but acquired the ability to replicate in human macrophages and stimulate macrophage Toll-like receptor 2. This study demonstrates that deletion of a gene associated with expression of a cell-wall lipid can result in acquisition of an immunostimulatory, invasive bacterial phenotype and has important implications for the study of M. abscessus pathogenesis at the cellular level.

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Mycobacterium abscessus Infection in Cystic Fibrosis

Cited by 153 publications

References 20 publications

Clinical Significance of a First Positive Nontuberculous Mycobacteria Culture in Cystic Fibrosis

Clinical Significance of a First Positive Nontuberculous Mycobacteria Culture in Cystic Fibrosis

Inhaled therapies, azithromycin andMycobacterium abscessusin cystic fibrosis patients

Deletion of the mmpL4b gene in the Mycobacterium abscessus glycopeptidolipid biosynthetic pathway results in loss of surface colonization capability, but enhanced ability to replicate in human macrophages and stimulate their innate immune response

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