Mycobacterium abscessus: a cutaneous infection in a patient on renal replacement therapy

Morris‐Jones, Rachael; Fletcher, Christopher D.�M.; Morris-Jones, Stephen; Brown, Timothy H.; Hilton, Rachel; Hay, R. J.

doi:10.1046/j.1365-2230.2001.00849.x

Cited by 22 publications

(7 citation statements)

References 14 publications

(28 reference statements)

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“…and a Spanish study by Escalonilla et al . Previous studies have highlighted the presence of NTM in water supplied to dialysis centers as well as tap water . We postulate that our observation may be due to the presence of M. abscessus in the environment (soil, decaying vegetation, tap, or environmental water in a tropical climate) in Singapore, thus increasing the risk of acquiring cutaneous infections for immunocompetent hosts.…”

Section: Discussionsupporting

confidence: 53%

Epidemiology, risk factors, and outcomes of adult cutaneous non‐tuberculous mycobacterial infection over a 10‐year period in Singapore

et al. 2018

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Background Unfamiliarity with the presentation, diagnostic process, and treatment of cutaneous non‐tuberculous mycobacterium (NTM) infection leads to poorer outcomes. We describe our experience with managing cutaneous NTM infection in a regional hospital in Singapore from 2005 to 2014. Methods Adult patients with cutaneous NTM infections were identified through positive skin tissue cultures in this retrospective case series. We excluded patients younger than 21 years of age, patients whose care was transferred to another hospital, and patients with catheter‐related infections. Data including demographic variables, as well as disease and treatment outcomes, were collected. We compared the data between patients with and without risk factors for immunosuppression to look for any significant difference. Results Fifty‐eight cases were reviewed. Mycobacterium abscessus was the commonest organism isolated (51.7%), and abscesses or inflamed cysts were the most common presentation. Nineteen specimens (57.6%) showed suppurative or necrotizing granulomatous dermatitis on biopsy and acid‐fast bacilli were identified in 2 of 21 histologic specimens (9.5%) stained for mycobacterium. Treatment included systemic antibiotics, surgery, or both. In total, 33 cases had clinical resolution while 25 cases were lost to follow‐up. Our study was limited by the under‐reporting of cases, bias due to data from a single center, and high dropout rates, thereby precluding a detailed assessment of treatment outcomes. Conclusions A high index of suspicion is required to diagnose cutaneous NTM infection. Education of both patients and physicians will help to raise the level of awareness and reduce treatment delays.

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Section: Discussionsupporting

confidence: 53%

Epidemiology, risk factors, and outcomes of adult cutaneous non‐tuberculous mycobacterial infection over a 10‐year period in Singapore

et al. 2018

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“…Multiple nodular lesions on the extremities, especially the lower leg, have been described as a clinical sign of disseminated infection [4]. However, isolated cutaneous infection with M. abscessus has been described in a patient on haemodialysis who developed multiple cutaneous abscesses on both lower legs [11]. …”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Infection with Mycobacteriumabscessus in a Renal Transplant Recipient

Prinz

Michaelis²,

Kettelhack³

et al. 2004

Dermatology

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Transplant recipients show a high incidence of infections, often with atypical manifestations mainly because of drug-related immunosuppression. Mycobacterial infections can be life-threatening in immunosuppressed patients due to the risk of dissemination. There have been only few reports of cutaneous infections with Mycobacterium abscessus among immunosuppressed patients. We present a rare case with a sporotrichoid skin infection with M. abscessus in a renal recipient. The value of immunohistochemical detection of mycobacteria using an anti-BCG antibody in the diagnostic work-up skin biopsies is demonstrated. Long-term antibiotic treatment resulted in complete remission, although recurrences with atypical presentation were observed.

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“…Retrospectively, M. chelonae might have been implicated in the previous pneumonia. Conditions predisposing to this infection include organ transplantation, rheumatoid arthritis 2 renal dialysis 3 and autoimmune disorders. In one series, only one patient was positive for human immunodeficiency virus but this patient was also taking steroids 1 .…”

Section: Reportmentioning

confidence: 99%

Disseminated cutaneous Mycobacterium chelonae infection with multidrug resistance in a patient with panuveitis

2008

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Mycobacterium abscessus: a cutaneous infection in a patient on renal replacement therapy

Cited by 22 publications

References 14 publications

Epidemiology, risk factors, and outcomes of adult cutaneous non‐tuberculous mycobacterial infection over a 10‐year period in Singapore

Epidemiology, risk factors, and outcomes of adult cutaneous non‐tuberculous mycobacterial infection over a 10‐year period in Singapore

Subcutaneous Infection with <i>Mycobacterium</i><i>abscessus</i> in a Renal Transplant Recipient

Disseminated cutaneous Mycobacterium chelonae infection with multidrug resistance in a patient with panuveitis

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