Moringa oleifera (Lam.): a natural remedy for ageing?

Abstract

disorderss. Effect of Moringa oleifera, is an age old ingredient of Indian aurvedic and traditional medicine was tested for its effect on age related antioxidant activity in Wistar albino rats of three age groups (6 and 18 months old) Aqueous extract of. M. oleifera leaves (MOAE) was administered orally at a dosage of 200mg/kg body wt. for a period of 30 days. MOAE treatment showed significant reduction in lipid peroxidation and lipofuscin pigmentation along with elevated serotonin and antioxidant enzymes in the brains of treated group of aged rats. D LC-MS-MS analysis revealed blood brain barrier permeable secondary metabolites viz.,9,9-bianthracene, 4-Methoxycinnamic acid, Cinnamic acid, (E)-p-coumaric acid pyrogallol and ostruthin from the extract. 9,9-bianthracene and ostruthin showed better binding affinity to Keap-1 and SERT in silicoThe present result suggests the protective efficacy of M oleifera against age related oxidative stress in brain.

Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation

“…Particularly, these polyphenols presented in moringa have been detected and quantified in blood (quercetin at a concentration of 0.0723 ± 0.0810 µM; kaempferol at a concentration of 0.0579 ± 0.0609 µM; apigenin at a concentration of 0.0106 ± 0.0123 µM and gallic acid at a concentration of 0.007 ± 0.003 µM) [ 52 , 53 , 54 ]. Additionally, Nair et al (2020) have recently demonstrated that compounds presented in moringa extracts are able to pass across Blood-brain-barrier (BBB) and to reach its pharmacological target [ 55 ]. Regarding the safe toxicological profile of moringa, doses of up to 2000 mg/kg of methanol and aqueous leaf extract were safe in animal studies [ 56 , 57 ].…”

Potential Anti-aging Components From Moringa oleifera Leaves Explored by Affinity Ultrafiltration With Multiple Drug Targets

“…For instance, M. oleifera leaf extracts displayed anti-aging activity by improving oxidative stress resistance and nutrient-sensing pathways ( 10 ), extending the life span, and improving stress tolerance of Caenorhabditis elegans ( 11 ). Moreover, it was also found that the M. oleifera leaf extracts observably decreased age-related neurodegeneration in the old treated rat model ( 12 ), and its cream restored skin vitality and reduced skin aging ( 13 ). However, the specific bioactive ingredients in M. oleifera leaf extracts that contributed most to its conspicuous antiaging activity remain unexplored until now.…”

Food Supplements for Skin Health: In Vitro Efficacy of a Combination of Rhodiola rosea, Tribulus terrestris, Moringa oleifera and Undaria pinnatifida on UV-Induced Damage

“…The anti-aging effects of Moringa oleifera seem not to be limited to the skin. In a rat model, oral administration of an aqueous extract of M. oleifera leaves (200 mg/kg) for 30 days determined significant reductions in lipid peroxidation and lipofuscin pigmentation along with elevated serotonin and antioxidant enzymes in the brain tissue [55]. Other studies confirmed that Moringa alleviates stress and has a neuroprotective function in murine models [56].…”