<i>Moraxella lacunata</i> Subacute Osteomyelitis in a Child

Fortesa, Mehmeti; Cochard, Blaise; Cuérel, Céline; Coulon, Geraldo De; Dayer, Romain; Steiger, Christina; Ceroni, Dimitri

doi:10.1093/jpids/piz089

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…For example, M. catarrhalis has been shown to colonize the respiratory tract of individuals, sometimes allowing the development of diseases such as otitis media, lower respiratory tract in COPD or older patients, nosocomial pneumonia, sinusitis and bacteremia [ 1 ]. Experience from infections by other species of the Moraxella genus is rare, with few infections being mentioned in the literature, such as keratitis, endophthalmitis, bacteremia, osteomyelitis, septic arthritis and endocarditis, even though reporting of such rare species may be highly influenced by publication bias [ 41 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Infective Endocarditis by Moraxella Species: A Systematic Review

Ιωάννου

Alexakis

Baliou

et al. 2022

JCM

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Moraxella catarrhalis is the most clinically relevant species among Moraxella spp. For decades, it was considered to be part of the normal human flora in the upper respiratory tract. However, since the late 1970s, considerable evidence has proposed that M. catarrhalis is an important pathogen in the human respiratory tract. Even though Infective Endocarditis (IE) is rarely caused by Moraxella spp., these infections can be problematic due to the lack of experience in their management. The aim of this study was to systematically review all published cases of IE by Moraxella spp. A systematic review of PubMed, Scopus and Cochrane library (through 8 December 2021) for studies providing epidemiological, clinical, microbiological data as well as treatment data and outcomes of IE by Moraxella spp. was performed. A total of 27 studies, containing data for 31 patients, were included. A prosthetic valve was present in 25.8%. Mitral valve was the most commonly infected site. Fever, sepsis and embolic phenomena were the most common clinical presentations. Cephalosporins, aminoglycosides, aminopenicillins and penicillin were the most commonly used antimicrobials. Overall mortality was 12.9%.

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Section: Discussionmentioning

confidence: 99%

Infective Endocarditis by Moraxella Species: A Systematic Review

Ιωάννου

Alexakis

Baliou

et al. 2022

JCM

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“…Of 5 children previously reported with invasive Moraxella lacunata infections, 4 had bacteremia and in 1 the organism was recovered from a patellar osteolytic lesion. [3][4][5][6]15 Of the 4 children with bacteremia, 2 had cardiac anomalies and developed infective endocarditis, 1 was previously well but developed meningitis, and the fourth was healthy but developed acute glomerulonephritis (Table 1). One child with infective endocarditis developed aortic valve vegetation while the other had mitral valve insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Eculizumab-Associated Moraxella lacunata Bacteremia and Systemic Inflammatory Response Syndrome in a Toddler with Atypical Hemolytic Uremic Syndrome

Bicoll

Goyal

Blatt

et al. 2021

Clin Med Insights Pediatr

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Moraxella lacunata, a low-virulence Gram-negative coccobacillus, is classically associated with conjunctivitis and upper respiratory tract infections; systemic infections such as sepsis have rarely been reported, especially in children. We describe a 28-month-old girl with atypical hemolytic uremic syndrome and stage II chronic kidney disease on long-term eculizumab therapy who presented with systemic inflammatory response syndrome and was found to have Moraxella lacunata bloodstream infection. Eculizumab, a humanized monoclonal anti-C5 antibody, has been associated with susceptibility to infections with encapsulated bacteria, especially Neisseria meningitidis. This is the first report of an invasive bacterial infection with Moraxella lacunata in a pediatric eculizumab recipient.

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“…The genus contains 18 species, including pathogens that cause infection in humans and animals ( Woodbury et al, 2009 ; Kubota et al, 2012 ). For instance, Moraxella lacunata can cause infections in the eye and the upper respiratory tract ( Woodbury et al, 2009 ; Mehmeti et al, 2021 ), while Moraxella osloensis and Moraxella catarrhalis , which are usually isolated from the human respiratory tract, can cause meningitis and pneumonia ( Murphy and Parameswaran, 2009 ; Lee et al, 2017 ). Overall, Moraxella spp.…”

Section: Introductionmentioning

confidence: 99%

Characterization of two novel colistin resistance gene mcr-1 variants originated from Moraxella spp.

YongLiang

et al. 2023

Front. Microbiol.

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This study aimed to characterize two novel mcr-1 variants, mcr-1.35 and mcr-1.36, which originated from Moraxella spp. that were isolated from diseased pigs in China. The Moraxella spp. carrying novel mcr-1 variants were subjected to whole-genome sequencing (WGS) and phylogenetic analysis based on the 16S rRNA gene. The mcr-1 variants mcr-1.35 and mcr-1.36 were characterized using phylogenetic analysis, a comparison of genetic environments, and protein structure prediction. The WGS indicated that two novel mcr-1 variants were located in the chromosomes of three Moraxella spp. with a genetic environment of mcr-1-pap2. In addition to the novel colistin resistance genes mcr-1.35 and mcr-1.36, the three Moraxella spp. contained other antimicrobial resistance genes, including aac(3)-IId, tet(O), sul2, floR, and blaROB-3. A functional cloning assay indicated that either the mcr-1.35 or mcr-1.36 gene could confer resistance to colistin in Escherichia coli DH5α and JM109. The nucleotide sequences of mcr-1.35 and mcr-1.36 presented 95.33 and 95.33% identities, respectively, to mcr-1.1. The phylogenetic analysis showed that mcr-1.35 and mcr-1.36 were derived from Moraxella spp. that belonged to subclades that were different from those of the mcr-1 variants (mcr-1.1 to mcr-1.34 except mcr-1.10) originating from Enterobacteriaceae. The deduced amino acid sequences of MCR-1.35 (MCR-1.36) showed 96.67% (96.49%), 82.59% (82.04%), 84.07% (83.52%), 55.52% (55.17%), 59.75% (59.57%), and 61.88% (61.69%) identity to MCR-1.10, MCR-2.2, MCR-6.1, MCR-LIN, MCR-OSL, and MCR-POR, respectively, that originated from Moraxella sp. Notably, protein structure alignment showed only a few changes in amino acid residues between MCR-1.1 and MCR-1.35, as well as between MCR-1.1 and MCR-1.36. In conclusion, this study identified Moraxella spp. carrying two novel mcr-1 variants, mcr-1.35 and mcr-1.36, conferring resistance to colistin, which were isolated from pig farms in China. In addition, mcr-like variants were observed to be located in the chromosomes of some species of Moraxella isolated from pig samples.

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Moraxella lacunata Subacute Osteomyelitis in a Child

Cited by 3 publications

References 7 publications

Infective Endocarditis by Moraxella Species: A Systematic Review

Infective Endocarditis by Moraxella Species: A Systematic Review

Eculizumab-Associated Moraxella lacunata Bacteremia and Systemic Inflammatory Response Syndrome in a Toddler with Atypical Hemolytic Uremic Syndrome

Characterization of two novel colistin resistance gene mcr-1 variants originated from Moraxella spp.

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