<i>Momordica charantia</i> (Indian and Chinese Bitter Melon) Extracts Inducing Apoptosis in Human Lung Cancer Cell Line A549 via ROS-Mediated Mitochodria Injury

Thiagarajan, Siroshini K; Arapoc, Daryl Jesus; Shafie, Nurul Husna; Yong, Yoke Keong; Bahari, Hasnah; Adam, Zainah; Ei, Thandar

doi:10.1155/2019/2821597

Cited by 13 publications

(11 citation statements)

References 32 publications

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“…(20). Methanol extract of M. charantia fruit induced apoptosis on A549 human lung cancer cells using various stains and caspase-3 and p53 activity (21). In agreement with these literature reports, it is assumed that M. cymbalaria consists of effective anticancer compounds which might be responsible for the observed cytotoxicity and apoptotic activities.…”

Section: Cytotoxic Activity and Apoptotic Inductionsupporting

confidence: 79%

Evaluation of antioxidant, cytotoxic and apoptotic activities of methanolic extract of momordica cymbalaria hook f. unripe fruit

Bhuvaneswari

Thirugnanasampandan²,

Ramnath

2020

krj

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Natural products gain more attention nowadays because of their compatibility with mankind, safe and economic feasible. The main purpose of this study was to evaluate antioxidant, cytotoxic and apoptotic activities of methanolic extract of Momordica cymbalaria Hook F. unripe fruit (UF). A considerable DPPH, hydroxyl radical scavenging and metal ion chelating activities and significant inhibitory effect on lipid peroxidation and least activity on deoxyribose degradation was observed for methanolic UF extract. Cytotoxic activity of UF extract on HeLa cells was observed and its inhibitory concentration fifty percent was calculated as 17.69±0.01µg/mL. Apoptosis inducing ability of UF extract on HeLa cells was also observed by Propidium iodide and acridine orange/ethidium bromide (AO/EtBr) dual staining. This is the first report on antioxidant, cytotoxic and apoptotic inducing ability of methanolic UF extract of Momordica cymbalaria collected from Sattur, Virudhunagar district, Tamilnadu, India.

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Section: Cytotoxic Activity and Apoptotic Inductionsupporting

confidence: 79%

Evaluation of antioxidant, cytotoxic and apoptotic activities of methanolic extract of momordica cymbalaria hook f. unripe fruit

Bhuvaneswari

Thirugnanasampandan²,

Ramnath

2020

krj

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“…Water extract and methanol extract of bitter melon plant leaf showed cytotoxic effects on human non-small cell lung cells A549 and lung adenocarcinoma cells CL1 in a dose-dependent manner, whereas normal human embryonic kidney HEK293 cells and lung WI-38 cells are less susceptible [50,52]. The α-MMC and MAP30 suppressed proliferation and induced S-phase cell cycle arrest and apoptosis in A549 cells in a dose-and time-dependent manner [51].…”

Section: Lung Cancermentioning

confidence: 97%

Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy

Sur

Ray

2020

Cancers

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Cancer is the second leading cause of death worldwide. Many dietary plant products show promising anticancer effects. Bitter melon or bitter gourd (Momordica charantia) is a nutrient-rich medicinal plant cultivated in tropical and subtropical regions of many countries. Traditionally, bitter melon is used as a folk medicine and contains many bioactive components including triterpenoids, triterpene glycoside, phenolic acids, flavonoids, lectins, sterols and proteins that show potential anticancer activity without significant side effects. The preventive and therapeutic effects of crude extract or isolated components are studied in cell line-based models and animal models of multiple types of cancer. In the present review, we summarize recent progress in testing the cancer preventive and therapeutic activity of bitter melon with a focus on underlying molecular mechanisms. The crude extract and its components prevent many types of cancers by enhancing reactive oxygen species generation; inhibiting cancer cell cycle, cell signaling, cancer stem cells, glucose and lipid metabolism, invasion, metastasis, hypoxia, and angiogenesis; inducing apoptosis and autophagy cell death, and enhancing the immune defense. Thus, bitter melon may serve as a promising cancer preventive and therapeutic agent.

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“…e plant is natively found in Asia, Africa, Amazon, and the Caribbean and is now widely cultivated in China and India for commercial purposes. Bitter gourd is valuable as a traditional herbal remedy with proven anti-inflammatory, antioxidant, anticarcinogenic, antimicrobial, and antidiabetic properties [137][138][139][140]. After several years of research, M. charantia is believed to be one of the most promising natural therapies that could be used to treat diabetes mellitus-a disease that affects numerous people all around the world [141].…”

Section: 5mentioning

confidence: 99%

A Review of Malaysian Herbal Plants and Their Active Constituents with Potential Therapeutic Applications in Sepsis

Liew

Hafiz

Chong

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Sepsis refers to organ failure due to uncontrolled body immune responses towards infection. The systemic inflammatory response triggered by pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria, is accompanied by the release of various proinflammatory mediators that can lead to organ damage. The progression to septic shock is even more life-threatening due to hypotension. Thus, sepsis is a leading cause of death and morbidity globally. However, current therapies are mainly symptomatic treatment and rely on the use of antibiotics. The lack of a specific treatment demands exploration of new drugs. Malaysian herbal plants have a long history of usage for medicinal purposes. A total of 64 Malaysian plants commonly used in the herbal industry have been published in Malaysian Herbal Monograph 2015 and Globinmed website (http://www.globinmed.com/). An extensive bibliographic search in databases such as PubMed, ScienceDirect, and Scopus revealed that seven of these plants have antisepsis properties, as evidenced by the therapeutic effect of their extracts or isolated compounds against sepsis-associated inflammatory responses or conditions in in vitro or/and in vivo studies. These include Andrographis paniculata, Zingiber officinale, Curcuma longa, Piper nigrum, Syzygium aromaticum, Momordica charantia, and Centella asiatica. Among these, Z. officinale is the most widely studied plant and seems to have the highest potential for future therapeutic applications in sepsis. Although both extracts as well as active constituents from these herbal plants have demonstrated potential antisepsis activity, the activity might be primarily contributed by the active constituent(s) from each of these plants, which are andrographolide (A. paniculata), 6-gingerol and zingerone (Z. officinale), curcumin (C. longa), piperine and pellitorine (P. nigrum), biflorin (S. aromaticum), and asiaticoside, asiatic acid, and madecassoside (C. asiatica). These active constituents have shown great antisepsis effects, and further investigations into their clinical therapeutic potential may be worthwhile.

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Momordica charantia (Indian and Chinese Bitter Melon) Extracts Inducing Apoptosis in Human Lung Cancer Cell Line A549 via ROS-Mediated Mitochodria Injury

Cited by 13 publications

References 32 publications

Evaluation of antioxidant, cytotoxic and apoptotic activities of methanolic extract of momordica cymbalaria hook f. unripe fruit

Evaluation of antioxidant, cytotoxic and apoptotic activities of methanolic extract of momordica cymbalaria hook f. unripe fruit

Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy

A Review of Malaysian Herbal Plants and Their Active Constituents with Potential Therapeutic Applications in Sepsis

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