<i>Momordica charantia</i>extracts protect against inhibition of endothelial angiogenesis by advanced glycation endproducts<i>in vitro</i>

Aljohi, Ali; Matou‐Nasri, Sabine; Liu, Donghui; Al-Khafaji, Nadia; Slevin, Mark; Ahmed, Nessar

doi:10.1039/c8fo00297e

Cited by 19 publications

(12 citation statements)

References 46 publications

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“…The high systemic blood glucose concentrations resulting from diabetes lead to non-enzymatic glycation of proteins and the formation of AGEs [ 3 , 33 ]. AGEs enhance macrophage polarization to the M1 phenotype and inhibit the proliferation of fibroblasts, resulting in the formation of a pro-inflammatory environment that hampers angiogenesis and re-epithelialization, leading to a non-healing wound [ 4 , 34 , 35 ]. Moreover, diabetic non-healing wounds are easily infected by bacteria, which accelerate and aggravate the pathology of the diabetic wound [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions

Zhang

Xia²,

Weng³

et al. 2022

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions

Zhang

Xia²,

Weng³

et al. 2022

Materials Today Bio

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“…Moreover, it has been reported that the hypoxic environment under moist wound dressings increased capillary proliferation; angiogenesis is faster in moist conditions (Boateng and Catanzano, 2015). In an in vitro study conducted by Aljohi et al (2018), it was reported that the methanolic extract of bitter melon had angiogenic effects. Singh et al (2017) reported that extracts of bitter melon topically can increase angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of bitter melon extract in the treatment of ischemic wounds in rats

Kısacık¹,

Güneş²,

Yaprakci³

et al. 2018

Turk J Biol

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There is no consensus on the properties of an ideal dressing for treating wounds. The aim of this study was to investigate the efficacy of dressings using topically administered bitter melon extract with olive oil, pure olive oil, nitrofurazone, and saline in the healing of ischemic wounds. A sample group of 48 rats was used in the trial. Their wounds were treated with bitter melon extract, pure olive oil, nitrofurazone, and saline. Data were collected between October 2014 and April 2015. The highest percentage (94.7%) of wound healing was observed in the bitter melon extract group and the lowest percentage (86.3%) in the nitrofurazone group. At the end of the 21st day, macroscopic reepithelialization was observed in 9 wounds in the bitter melon extract group (75%), in 6 wounds in the pure olive oil group (50%), and in only 3 wounds in the nitrofurazone and saline groups (25%). It can be concluded that dressing with a bitter melon extract is more efficient in the treatment of wounds than using nitrofurazone or saline, and that dressing with olive oil accelerates wound healing, although not as much as dressing with bitter melon extract.

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“…Scientists claimed that it stimulated tube formation from bovine aortic endothelial cells (BAEC) to promote angiogenesis. 110 As one step further, injectable platelet‐rich fibrin (PRF) with a co‐culture of OECs (sprouting endothelial cells) and primary osteoblasts (pOBs) was found to represent another unique template for angiogenesis network formation after about 1 week. 111 Finally, a new framework for generating a neurovascular unit (NVU) (NVU consists of neurons, glial cells, blood vessels, and ECM proteins) composed of a fibrin-matrigel matrix seeded with BMECs/MSCs, which developed new blood vessels.…”

Section: Natural Biomaterials-derived Scaffoldsmentioning

confidence: 99%

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

Shokrani¹,

Shokrani²,

Sajadi³

et al. 2022

IJN

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One of the most arduous challenges in tissue engineering is neovascularization, without which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be completed at an optimal density and within an appropriate period of time to prevent cell necrosis. Failure to meet this challenge brings about poor functionality for the tissue in comparison with the native tissue, extensively reducing cell viability. Prior studies devoted to angiogenesis have provided researchers with some biomaterial scaffolds and cell choices for angiogenesis. For example, while most current angiogenesis approaches require a variety of stimulatory factors ranging from biomechanical to biomolecular to cellular, some other promising stimulatory factors have been underdeveloped (such as electrical, topographical, and magnetic). When it comes to choosing biomaterial scaffolds in tissue engineering for angiogenesis, key traits rush to mind including biocompatibility, appropriate physical and mechanical properties (adhesion strength, shear stress, and malleability), as well as identifying the appropriate biomaterial in terms of stability and degradation profile, all of which may leave essential trace materials behind adversely influencing angiogenesis. Nevertheless, the selection of the best biomaterial and cells still remains an area of hot dispute as such previous studies have not sufficiently classified, integrated, or compared approaches. To address the aforementioned need, this review article summarizes a variety of natural and synthetic scaffolds including hydrogels that support angiogenesis. Furthermore, we review a variety of cell sources utilized for cell seeding and influential factors used for angiogenesis with a concentrated focus on biomechanical factors, with unique stimulatory factors. Lastly, we provide a bottom-to-up overview of angiogenic biomaterials and cell selection, highlighting parameters that need to be addressed in future studies.

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Momordica charantiaextracts protect against inhibition of endothelial angiogenesis by advanced glycation endproductsin vitro

Abstract: Momordica charantia extracts protect against advanced glycation endproduct-induced anti-angiogenisis in vitro.

Cited by 19 publications

References 46 publications

Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions

Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions

Effectiveness of bitter melon extract in the treatment of ischemic wounds in rats

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

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