MMP2andMMP10Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population

Abstract

Background. Steroid-induced osteonecrosis of the femoral head is a relatively serious condition which seriously reduces patient quality of life. However, the pathogenesis of steroid-induced ONFH is still unclear. In recent years, more scholars have found that the pathogenesis of steroid-induced ONFH is related to susceptibility factors such as MMPs/TIMPs system. The main purpose of this study is to investigate the correlation between MMP2 and MMP10 gene polymorphisms and steroid-induced ONFH in Chinese Han population. Methods. Six SNPs in MMP2 and two SNPs in MMP10 were genotyped using Agena MassARRAY RS1000 system from 286 patients of steroid-induced ONFH and in 309 healthy controls. The association between MMP2 and MMP10 polymorphisms and steroid-induced ONFH risk were estimated by the Chi-squared test, genetic model analysis, haplotype analysis, and stratification analysis. The relative risk was estimated by odd ratios (ORs) and 95% confidence intervals (CIs). Result. We found that the minor TG allele of rs470154 in MMP10 was associated with an increased risk of steroid-induced ONFH (OR = 1.45, 95% CI, 1.03 – 2.05, p = 0.032). In the genetic model analysis, we found that rs2241146 in MMP2 gene and rs470154 in MMP10 gene showed a statistically significant association with increased risk of steroid-induced ONFH. The six SNPs (rs470154, rs243866, rs243864, rs865094, rs11646643, and rs2241146) showed a statistically significant association with different clinical phenotypes. Conclusion. Our results verify that genetic polymorphisms of MMP2 and MMP10 contribute to steroid-induced ONFH susceptibility in the population of Chinese Han population, and our study provides new insights into the role that MMP2 and MMP10 plays in the mechanism of ONFH.

The protective effects of microRNA-26a in steroid-induced osteonecrosis of the femoral head by repressing EZH2

“…As a subtype of non-traumatic ONFH, steroidinduced ONFH (SONFH) is correlated with the elevation of pressure in bone that was resulted from increased lipogenesis and hyperplasia of adipocytes in bone marrow, which could decelerate the blood flow in FH and eventually cause avascular osteonecrosis [3]. According to the statistics, there were 150,000-200,000 patients newly diagnosed with ONFH every year in China until 2017 [4], and SONFH was diagnosed in 24.1% of the ONFH patients [5]. The incidence of SONFH is correlated with the management methods and the dose of the steroid.…”

Screening of Potential Biomarkers in the Peripheral Serum for Steroid-Induced Osteonecrosis of the Femoral Head Based on WGCNA and Machine Learning Algorithms

“…SONFH is a complicated disease of the femoral head with complex pathogenesis, including genetic and environmental factors [26]. According to statistics, there are approximately 36,000 to 48,000 new SONFH patients in China each year [27,28]. Currently, the clinical diagnosis of SONFH is sometimes full of significant difficulties due to the lack of frequent symptoms and valid diagnostic biomarkers, especially in the early stage of SONFH, and ultimately resulting in that most patients miss the best time for treatment and become difficult to reverse [29,30].…”

MMP2 Polymorphisms and Colorectal Cancer Susceptibility in a Chinese Han Population

“…10,11 Furthermore, MMP2 gene polymorphisms are associated with risk for multiple diseases. The rs2241146 single nucleotide polymorphism (SNP) in MMP2 is associated with an increased risk of steroid-induced osteonecrosis of the femoral head in the Chinese Han population, 12 while another MMP2 SNP, rs243865, is not associated with susceptibility to breast cancer. 13 Although there are many reports showing that CRC risk is influenced by genetic susceptibility, specific associated genes and details of mechanisms underlying the contributions of a major proportion of risk loci identified by polymorphism analysis remain largely unknown.…”