<i>MMP-3</i> and <i>MMP-8</i> single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males

Chen, Junyu; Liu, Wanlin; Cao, Yong; Zhang, Xiyang; Yong-chang, Guo; Zhu, Yong; Li, Jian; Du, Jieli; Jin, Tianbo; Wang, Guoqiang; Wang, Jianzhong

doi:10.18632/oncotarget.15587

Cited by 28 publications

(26 citation statements)

References 40 publications

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“…In the present study, we investigated nine SNPs in the MMP8 and MMP9 genes. Among these SNPs, rs3740938, rs2012390, rs11225394, rs2274755 and rs3918254 were identified that have been associated with risk of osteonecrosis of the femoral head in the Chinese Han population 20 , 21 , 30 . We report for the first time that rs11225394 was associated with BC risk.…”

Section: Discussionmentioning

confidence: 99%

MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population

Wang

Zhou

et al. 2018

Sci Rep

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Matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that can breakdown almost all extracellular matrix components. MMP8 and MMP9 have been shown to be associated with breast cancer (BC) risk in European and American populations. However, few studies have focused on the polymorphisms of MMP8 and MMP9 in Chinese Han BC patients. We investigated nine single nucleotide polymorphisms (SNPs) in 571 BC cases and 578 controls to evaluating their association with risk of BC. The frequency of the “A” allele of rs3787268 was significantly lower in BC cases than in controls (P = 0.025). In the genetic model analysis, the minor allele “T” of rs11225394 in MMP8 was associated with increased risk of BC under the recessive model (P = 0.019), and the minor allele “A” of rs3787268 was associated with decreased risk of BC under the dominant model (P = 0.014). Additionally, the haplotype “AGTCA” constructed by rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 and the haplotype “CCG” constructed by rs3918249, rs3918254 and rs3787268 were associated with increased risk of BC (P < 0.05). Our data showed that polymorphisms of MMP8 and MMP9 may be associated with BC risk in the Chinese Han population.

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Section: Discussionmentioning

confidence: 99%

MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population

Wang

Zhou

et al. 2018

Sci Rep

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“…[ 19 , 20 ] Recently, several studies investigated the correlation between MMP-8 and the risk of ONFH. [ 12 , 17 , 21 , 22 ] Du et al [ 11 ] shown that MMP-8 rs2012390 was associated with an increased risk of ONFH. However, Chen et al [ 12 ] reported that MMP-8 rs2012390 decreased the risk of ONFH.…”

Section: Discussionmentioning

confidence: 99%

“…Du et al [ 11 ] shown that MMP-8 rs2012390 was associated with an increased risk of ONFH. However, Chen et al [ 12 ] reported that MMP-8 rs2012390 decreased the risk of ONFH. Thus far, no meta-analysis has yet been carried out to evaluate the relationships between MMP-8 rs2012390 and rs11225394 polymorphisms and ONFH.…”

Section: Introductionmentioning

confidence: 99%

Association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head risks

2018

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Background:The association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head (ONFH) risks was investigated in several studies with conflicting results. We performed the meta-analysis to evaluate the association between them.Methods:Potentially relevant literatures were searched from the electronic databases of PubMed, Web of Science, and Cochrane Library. All databases were searched up to May 6, 2018. The strength of associations of the MMP-8 rs2012390 and rs11225394 polymorphisms with ONFH risk was assessed by crude odds ratios (ORs) with their 95% confidence intervals (CIs) under different genetic models.Results:A total of 1469 cases diagnosed with ONFH and 1211 healthy controls were included in the current meta-analysis. A remarkable association between rs11225394 in the MMP-8 gene and an increased risk of ONFH was found (allele model: OR = 1.33, 95% CI = 1.09–1.61, P = .005; heterozygote model: OR = 1.39, 95% CI = 1.13–1.71, P = .002; dominant model: OR = 1.40, 95% CI = 1.14–1.73, P = .002, respectively). Meanwhile, a significant association between MMP-8 rs2012390 and the decreased risk of ONFH was found in heterozygote model (OR = 0.63, 95% CI = 0.51–0.77, P < .00001).Conclusion:The meta-analysis results showed a remarkable association between rs11225394 in MMP-8 gene and an increased risk of ONFH and a significant association between MMP-8 rs2012390 and the decreased risk of ONFH.

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“…After the use of PRP was verified as a useful management strategy for ONFH treatment by Yokota et al [23], many clinical and epidemiological studies started to research the mechanism of PRP in ONFH treatment. Numerous studies have reported that enhancing osteogenesis and angiogenesis to reconstruct the bone structure of necrotic areas is the main mechanism involved in early-stage ONFH treatment [1,24,25]. In light of the above rationale, PRP could augment core decompression and bone graft substitutes to treat earlystage ONFH through increasing the levels of various cytokines that initiate and regulate proliferation, differentiation, and angiogenesis [16,17,26] ( Figure 2).…”

Section: The Mechanism Of Prp In Onfh Treatmentmentioning

confidence: 99%

The use of platelet-rich plasma for the treatment of osteonecrosis of the femoral head: A systematic review

Han

Gao²,

Sun³

et al. 2019

Preprint

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Background: As a pathological process, osteonecrosis of the femoral head (ONFH) is characterized by the avascularity of the femoral head, cellular necrosis, microfracture, and the collapse of the articular surface. Currently, critical treatment for early stage ONFH is limited to core decompression. However, the efficacy of core decompression remains controversial. To improve the core decompression efficacy, regenerative techniques such as the use of platelet-rich plasma (PRP) were proposed for early stage ONFH. As a type of autologous plasma containing concentrations of platelets greater than the baseline, PRP plays an important role in tissue repair, regeneration, and the differentiation of mesenchymal stem cells (MSCs). In this review, we present a comprehensive overview of the operation modes, mechanism and efficacy of PRP for early stage ONFH treatment. Methods: We searched for relevant studies in the PubMed, Web of Science, and Embase databases. By searching these electronic databases, the identification of either clinical or experimental studies evaluating PRP, MSC, core decompression and ONFH was our goal. Results: Seventeen studies of PRP and avascular necrosis of the femoral head were evaluated in our review. Ten studies related to the possible mechanism of PRP for treating ONFH were reviewed. Seven studies of the operation modes of PRP in treating ONFH were identified. We reviewed the efficacy of PRP in treating ONFH systematically and made an attempt to compare the PRP operation modes in 7 studies and other operation modes in past studies for early stage ONFH treatment. Conclusion: PRP treats ONFH mainly through three mechanisms: inducing angiogenesis and osteogenesis to accelerate bone healing; inhibiting inflammatory reactions in necrotic lesions; and preventing apoptosis induced by glucocorticoids. In addition, as an adjunctive therapy for core decompression, the use of PRP is recommended to improve the treatment of early stage ONFH patients, especially when combined with stem cells and bone grafts, by inducing osteogenic activity and stimulating the differentiation of stem cells in necrotic lesions.

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MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males

Cited by 28 publications

References 40 publications

MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population

MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population

Association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head risks

The use of platelet-rich plasma for the treatment of osteonecrosis of the femoral head: A systematic review

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