mir-126 rs4636297 and TGFβRI rs334348 functional gene variants are associated with susceptibility to endometriosis and its severity

Sepahi, Neda; Kohan, Leila; Jahromi, Athar Rasekh; Daneshbod, Yahya; Hoveidi, Elahe Nimi

doi:10.1080/09513590.2017.1290064

Cited by 11 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…G allele of this SNP has been shown to protect against endometriosis. Moreover, significant association has also been detected between the A allele and severity of endometriosis (72). Zhang et al have shown association between the CT/CC genotypes of miR-146b rs1536309 and the risk of pain symptom of endometriosis.…”

Section: Mirnas and Endometriosismentioning

confidence: 99%

Role of Non-coding RNAs in the Pathogenesis of Endometriosis

2020

View full text Add to dashboard Cite

Endometriosis is a disorder characterized by the presence of endometrial glands and stroma like lesions outside of the uterus. Although several hypothesis have tried to explain the underlying cause of endometriosis, yet the main cause remained obscure. Recent studies have shown contribution of non-coding RNAs in the pathogenesis of endometriosis. Two classes of these transcripts namely long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have mostly attracted attention of researchers. Several studies have reported aberrant expression of these transcripts in affected tissues from patients as well as animal models. Modulation of important signaling pathways such as PI3K/AKT, P38-MAPK, ERK1/2-MAPK and Wnt-β catenin by miRNAs and lncRNAs have potentiated these molecules as biomarkers or therapeutic agents in endometriosis. Single nucleotide polymorphisms with miR-126, miR-143 and miR-146b have been associated with risk of endometriosis. Moreover, miRNAs and lncRNAs control inflammatory responses, cell proliferation, angiogenesis and tissue remodeling, thus understanding the role of these transcripts in endometriosis is a possible way to develop novel diagnostic tests and therapeutic targets for this disorder.

show abstract

Section: Mirnas and Endometriosismentioning

confidence: 99%

Role of Non-coding RNAs in the Pathogenesis of Endometriosis

2020

View full text Add to dashboard Cite

show abstract

“…We report significant associations of rs895819 and rs6505162 SNPs with higher rates of endometriosis, but no link with rs531564. The significance of miRNAs and their variants in different diseases have been indicated frequently ( 16 , 17 ), whereas several studies have specifically investigated the effects of miRNAs variants in female reproductive disorders, a few studies have been focused to determine the role of miRNAs variants in endometriosis ( 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Variants miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are Linked to Endometriosis and its Severity

et al. 2022

View full text Add to dashboard Cite

Background: While different studies have investigated the association of SNPs with female reproductive disorders, a limited number of studies have investigated the effect of microRNAs variants in endometriosis. In this study, we evaluated the prevalence and the association of three different miRNAs variants including, miR-27a rs895819, miR-124-1 rs531564, and miR-423 rs6505162 with endometriosis to help further elucidate the importance of these variants in female reproductive disorders.Methods: A total number of 440 women (220 cases and 220 controls) were included. DNA was extracted and genotyping of the SNPs was carried out by PCR.Results: The results showed that rs895819 and rs6505162 had a significant association with endometriosis under the dominant, recessive, co-dominant, and allelic model, but rs531564 was not linked to endometriosis. Our results also imply a protective effect on endometriosis severity for AG genotype and G allele in rs895819 (p < 0.001), and also for AA and AC genotypes in rs6505162 with severity in endometriosis (p < 0.001). Moreover, Hardy–Weinberg equilibrium, haplotype frequency, and linkage disequilibrium between SNPs were performed.Conclusion: miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are linked to endometriosis.

show abstract

“…Several studies have also confirmed the strong relationship of miRNA SNPs with increased risk of endometriosis incidence among women. A study of 157 endometriosis patients and 252 healthy women, mir-126 rs4636297 significantly differed between the two groups, the authors speculating a role in individual’s susceptibility to endometriosis and its severity [ 24 ]. Similarly, Farsimadan et al in a very recent study investigating the association of miR-146a, miR-149 rs2292832, miR-196a2, and miR-499 variants with the higher rates of endometriosis, suggested the importance of these SNPs with disease severity [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants miR-126, miR-146a, miR-196a2, and miR-499 in Polycystic Ovary Syndrome

Jaafar

et al. 2022

Br J Biomed Sci

View full text Add to dashboard Cite

Introduction: Alterations in certain microRNAs (miRNAs) and their target genes have reported in polycystic ovary syndrome (PCOS) and other disease of the female reproductive system, and so may be potential biomarkers. We hypothesised alterations in the prevalence of four miRNAs single nucleotide polymorphism (SNP) variants miR-126 rs4636297, miR-146a rs2910164, miR-196a2 rs11614913, and miR-499 rs3746444 in women with PCOS in comparison to healthy controls.Methods: SNPs in the four miRNAs were determined in 385 patients and 385 controls by standard RT-PCR techniques.Results: SNPs in miR-126 and miR-246a were significant linked with PCOS under the allelic, dominant, co-dominant, and recessive models (all p ≤ 0.01). The SNP in miR-499 was linked to PCOS in allelic (T, p = 0.002), dominant (p = 0.035) and recessive (p = 0.003) models. The SNPs -196a was significant linked to PCOS only in the recessive model (p = 0.037). Combining these SNPs in miR-499, mi146a, miR-196a and miR-126 respectively into allele haplotypes found highly significant odds ratios (95% CI) of 0.40 (0.29–0.54) (p < 0.001) for the C-G-C-G haplotype, and 0.46 (0.30–0.70) (p = 0.002) for the C-C-C-A haplotype (p = 0.002) for PCOS.Conclusion: Single SNPs and haplotype combinations in certain SNPs in miR-126, miR-146a, miR-196a2 and miR-499 are strongly linked to PCOS, and so may be useful predictors of this condition.

show abstract

mir-126 rs4636297 and TGFβRI rs334348 functional gene variants are associated with susceptibility to endometriosis and its severity

Cited by 11 publications

References 24 publications

Role of Non-coding RNAs in the Pathogenesis of Endometriosis

Role of Non-coding RNAs in the Pathogenesis of Endometriosis

MicroRNA Variants miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are Linked to Endometriosis and its Severity

Genetic Variants miR-126, miR-146a, miR-196a2, and miR-499 in Polycystic Ovary Syndrome

Contact Info

Product

Resources

About