MCP1 −2518Polymorphism and chronic obstructive pulmonary disease in Taiwanese men

Abstract

Monocyte chemoattractant protein-1 (MCP-1) plays a major role in the recruitment of inflammatory cells to the lungs of patients with chronic obstructive pulmonary disease (COPD). However, the influence of MCP1 gene polymorphism on COPD development has not been studied. This study aimed to investigate the association between MCP1 -2518 polymorphisms and COPD and between this polymorphism and plasma MCP-1 levels. The plasma MCP-1 was measured by using an enzyme-linked immunosorbent assay and polymorphisms detection was performed by denaturing high-performance liquid chromatography. COPD group had higher plasma MCP1 levels than healthy participants (257.0 versus 194.4 pg/mL) in the univariate analysis (P = .005); and in stepwise liner regression analysis after adjustment for age, alcohol, body mass index, cancer history, and steroid use (P = .002; 95% confidence interval [CI]: 30.72-128.02). Plasma MCP-1 was negatively correlated with forced expiratory volume in one second (FEV(1)%) (P = .003; r = -.274). SNPStats including codominant, dominant, recessive, overdominant, and log-additive model analysis showed MCP1 -2518 polymorphisms had no association with the risk of COPD. Generalized linear model showed no association between plasma MCP-1 levels and MCP1 -2518 genotypes. In conclusion, there is no association between MCP1 -2518 gene polymorphisms and COPD or between this gene polymorphisms and plasma MCP-1 levels in the Taiwanese men.

Blood MCP-1 levels are increased in chronic obstructive pulmonary disease patients with prevalent emphysema

“…Smoking induces a significant increase of monocyte chemotactic protein (MCP)-1 levels in the bronchoalveolar lavage (BAL) fluid of both healthy smokers 3 and patients with chronic bronchitis, 4 and COPD patients show higher plasma MCP-1 levels compared with healthy controls. 5 However, MCP-1 plasma levels have not been analyzed according to the different COPD phenotypes. Both interleukin (IL)-1α and IL-1β are proinflammatory cytokines produced mainly by monocytes, macrophages, and fibroblasts.…”

The Association of MCP-1 Level and MCP-1 -2518 A/G and CCR2 190 G/A Gene Polymorphisms with COPD and Pulmonary Hypertension

“…In some studies, it is stated that MCP-1 -2518 A/G and CCR2 190 G/A gene polymorphisms may be effective in COPD formation (12). Liu et al found no association between MCP1 -2518 gene polymorphism and COPD and this gene polymorphism and plasma MCP-1 levels in the Taiwanese men (26).…”

Effects of the Inhalation of the M3 Receptor Antagonist Bencycloquidium Bromide in A Mouse Cigarette Smoke‐Induced Airway Inflammation Model

“…MCP‐1 levels are increased in the sputum, BALF, and lungs of patients with COPD, and MCP‐1 is also expressed in macrophages, T‐cells, endothelial cells, and bronchial epithelial cells of human lung [de Boer et al, ; Traves et al, ]. In smokers with COPD, expression of MCP‐1 is elevated as compared to non‐COPD smokers and acts as a potent chemoattractant for neutrophils and monocytes [Liu et al, ; Blidberg et al, ]. MCP‐1 and MIP‐1a are validated markers for chronic inflammation in COPD patients and consequently compounds that inhibit neutrophil influx and chemokine expression may be effective in attenuating COPD progression.…”