<i>MC4R rs17782313</i>gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study

Mutombo, Paulin Beya wa Bitadi; Yamasaki, Masayuki; Hamano, Tsuyoshi; Isomura, Minoru; Nabika, Toru; Shiwaku, Kuninori

doi:10.3109/07435800.2013.844163

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…The further meta-analysis combining previous and our current findings supported the above finding and gave a more precise estimate of the effect of MC4R on type 2 diabetes in Chinese by raising the sample size to 15 462 diabetic patients and 13 865 controls. In addition, our results were in accordance with a previous meta-analysis involving multiethnic populations by Xi et al [10] .Notably, a recent study in Japanese found that rs17782313 was related to glycated hemoglobin, which could be used in type 2 diabetes screening in populations independent of BMI, indicating the potential value of MC4R in type 2 diabetes prediction [39] .…”

Section: Discussionsupporting

confidence: 92%

Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population

et al. 2014

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Background and AimsObesity is a well-known risk factor for type 2 diabetes. Genome-wide association studies have identified a number of genetic loci associated with obesity. The aim of this study is to examine the contribution of obesity-related genomic loci to type 2 diabetes in a Chinese population.MethodsWe successfully genotyped 18 obesity-related single nucleotide polymorphisms among 5338 type 2 diabetic patients and 4663 controls. Both individual and joint effects of these single nucleotide polymorphisms on type 2 diabetes and quantitative glycemic traits (assessing β-cell function and insulin resistance) were analyzed using logistic and linear regression models, respectively.ResultsTwo single nucleotide polymorphisms near MC4R and GNPDA2 genes were significantly associated with type 2 diabetes before adjusting for body mass index and waist circumference (OR (95% CI) = 1.14 (1.06, 1.22) for the A allele of rs12970134, P = 4.75×10−4; OR (95% CI) = 1.10 (1.03, 1.17) for the G allele of rs10938397, P = 4.54×10−3). When body mass index and waist circumference were further adjusted, the association of MC4R with type 2 diabetes remained significant (P = 1.81×10−2) and that of GNPDA2 was attenuated (P = 1.26×10−1), suggesting the effect of the locus including GNPDA2 on type 2 diabetes may be mediated through obesity. Single nucleotide polymorphism rs2260000 within BAT2 was significantly associated with type 2 diabetes after adjusting for body mass index and waist circumference (P = 1.04×10−2). In addition, four single nucleotide polymorphisms (near or within SEC16B, BDNF, MAF and PRL genes) showed significant associations with quantitative glycemic traits in controls even after adjusting for body mass index and waist circumference (all P values<0.05).ConclusionsThis study indicates that obesity-related genomic loci were associated with type 2 diabetes and glycemic traits in the Han Chinese population.

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Section: Discussionsupporting

confidence: 92%

Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population

et al. 2014

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“…Mutombo et al demonstrated that the carriers of the T/C + C/C genotypes of the MC4R rs17782313 polymorphism had a visibly higher BMI and higher levels of glycated haemoglobin than those with the T/T genotype, even after taking into account such variables as age and gender. Proneness to type 2 diabetes in this group was not linked to a tendency to obesity [12]. A study of the Chinese population, on the other hand, suggested a relationship between the C/T genotype of the MC4R rs17782313 polymorphism and a higher waist-to-hip ratio, even after multiple testing correction [30].…”

Section: Discussionmentioning

confidence: 62%

“…One more genetic factor that substantially contributes to obesity -thus predisposing to carbohydrate metabolism disorders and type 2 diabetes -is the melanocortin-4 receptor (MC4R) rs17782313 polymorphism [12]. It is considered to play an important part in the regulation of food intake, and maintenance of long-term energy homeostasis [13].…”

Section: Introductionmentioning

confidence: 99%

Seeking genetic determinants of selected metabolic disorders in women aged 45–60

Szkup

Brodowski

Jurczak

et al. 2020

Ann Agric Environ Med.

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Introduction and objective. The biochemical and anthropometric consequences of metabolic disorders exert an enormous effect on the functioning of people worldwide. The aim of this study is to assess relationships between biochemical and anthropometric parameters associated with metabolic syndrome, and the presence of the PPAR-γ rs1801282, the FTO rs9939609, and the MC4R rs17782313 polymorphisms in women aged 45-60. Materials and method. The study included 425 women, aged 45-59 years, from the general population of the West Pomeranian Province in northwest Poland. The research procedure involved a structured interview, anthropometric and blood pressure measurements, biochemical analysis of serum, and genetic analysis. Results.

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“…Melanocortin-4 receptor, which is coded by the MC4R gene, is a key protein in regulation of energy balance, adiposity, and glucose metabolism 10 , 16 , 17 . The common variants in the MC4R gene have been previously related to measures of glucose metabolism such as insulin resistance 16 , insulin sensitivity 11 , and HbA1c 19 . Our data suggest that the MC4R genotype may also play a role in regulating postpartum change patterns of glycemic profiles caused by pregnancy.…”

Section: Discussionmentioning

confidence: 99%

The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis

Carvalho

Shao

Liu

et al. 2017

Sci Rep

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The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers among women with prior gestational diabetes mellitus (GDM). The MC4R genotype, postpartum weight reduction, and glycemic changes between after delivery and pregnancy were assessed in a cohort of 1208 Chinese women who had experienced GDM. The adiposity-increasing allele (C) of the MC4R variant rs6567160 was associated with greater postpartum increase of HbA1c (β = 0.08%; P = 0.03) and 2-hour OGTT glucose concentrations (β = 0.25 mmol/L; P = 0.02). In addition, we found an interaction between the MC4R genotype and postpartum weight reduction on changes in fasting plasma glucose (P-interaction = 0.03). We found that the MC4R genotype was associated with postpartum glycemic changes; and the association with fasting glucose were significantly modified by postpartum weight reduction in women who had experienced GDM.

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MC4R rs17782313gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study

Abstract: MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.

Cited by 10 publications

References 18 publications

Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population

Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population

Seeking genetic determinants of selected metabolic disorders in women aged 45–60

The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis

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