<i>MBL2</i>Variations and Malaria Susceptibility in Indian Populations

Jha, Aditya Nath; Sundaravadivel, Pandarisamy; Singh, Vipin Kumar; Pati, Sudhanshu S.; Patra, Pradeep Kumar; Kremsner, Peter G.; Velavan, Thirumalaisamy P.; Singh, Lalji; Thangaraj, Kumarasamy

doi:10.1128/iai.01041-13

Cited by 30 publications

(33 citation statements)

References 51 publications

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“…In order to avoid identifying allelic associations that were actually due to other genetic variations associated with race, we excluded study participants who did not self-report being Caucasian; and thus additional research will be required for establishing severity correlates in other populations. We were concerned that variation in genes such as MBL2 that show race-associated differences in allele frequency and that have been shown to be associated with infection severity could confound our results (37-39). Self-reported ancestry can be imperfect and future research can potentially include genetic assessment of the background of the participants.…”

Section: Discussionmentioning

confidence: 99%

HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

et al. 2016

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Variation at HLA and KIR loci is associated with the severity of viral infections. To assess associations of genital HSV-2 infection with human HLA and KIR genetic loci, we measured the frequencies of genital HSV DNA detection and of genital lesions in HSV-2 seropositive persons. We followed 267 HSV-2 seropositive persons who collected daily genital swabs and recorded lesions for ≥30 days. All persons were laboratory- documented as HIV-seronegative, and all were Caucasian by self-report. HSV detection rate and lesion frequency were compared by genotype using Poisson regression. Overall, HSV was detected on 19.1% of days and lesions on 11.6% of days. The presence of HLA-A*01 was directly associated with HSV detection frequency while the presence of HLA-C*12 was inversely associated with HSV detection frequency. The presence of HLA-A*01 was directly associated with lesion rate, while HLA-A*26, -C*01 and -DQB1*0106 were associated with decreased lesions. We observed an interaction between the absence of both 2DS4del and HLA-Bw4 and higher lesion rate. Heterozygosity of HLA was also associated with reduced lesion frequency. Immune control of genital HSV infection relies on multiple interacting immunogenetic elements, including epistatic interactions between HLA and KIR.

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Section: Discussionmentioning

confidence: 99%

HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

et al. 2016

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“…In addition, three non-synonymous [18]. Lectin complement proteins have been associated with many infectious diseases including intra and extracellular infections [22][23][24][25]. Our earlier study has shown that, another analogous lectin complement protein ficolin-2 was associated with occurrence of VL [26].…”

Section: Accepted Manuscriptmentioning

confidence: 92%

“…The MBL2*LYQA haplotype is associated with higher MBL expression and reduced risk in severe malaria patients [45]. The MBL2*LYPA haplotype was associated to be a risk factor in a study on Brazilian patients with leprosy caused by another intracellular pathogen [46].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis

Mishra

Antony

Gai

et al. 2015

Parasitology International

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“…Although the role of MBL2 genetic variants has been investigated widely in different diseases, infections, and pathophysiological conditions [as a recent examples see Takahashi, 2011;Heitzeneder et al, 2012;Carvalho et al, 2013;Evans-Osses et al, 2013;Lu et al, 2013;Swierzko et al, 2013;Wan et al, 2013;Ingels et al, 2014;Jha et al, 2014], no previous studies have investigated the possible correlation between MBL2 polymorphisms and atypical squamous cells of undetermined significance susceptibility.…”

Section: Discussionmentioning

confidence: 99%

MBL2polymorphisms in women with atypical squamous cells of undetermined significance

et al. 2015

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Infection with high risk Human papillomavirus (HPV) is the main known cause of cervical cancer. HPV induces different grades of lesions: among them, Atypical squamous cells of undetermined significance are abnormal lesions that could evolve in pre-cancer lesions or spontaneously regress. The mannose binding lectin (MBL) is an innate immunity serum protein also found in cervico-vaginal mucosa, whose expression is known to be affected by polymorphisms in exon 1 and promoter of the MBL2 gene. In the present study the possible association between MBL2 functional polymorphisms and susceptibility to develop atypical squamous cells of undetermined significance was investigated in a group of women from North-East of Italy, stratified for HPV infection status. The MBL2 D and O alleles and the deficient producer combined genotypes, responsible for low MBL production, were more represented among atypical squamous cells of undetermined significance positive women than healthy controls and the results were confirmed when only HPV negative samples were considered. These results suggest a possible involvement of MBL2 functional polymorphisms in atypical squamous cells of undetermined significance susceptibility.

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MBL2Variations and Malaria Susceptibility in Indian Populations

Cited by 30 publications

References 51 publications

HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions

Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis

MBL2polymorphisms in women with atypical squamous cells of undetermined significance

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