Maximal Diffusing Capacity of the Lung in Normal Male Subjects of Different Ages

150

The occurrence of arterial hypoxia with polycythemia usually results from some known type of pulmonary disease or from an abnormal communication between the right and left sides of the circulation. Although arterial oxygen unsaturation has been observed in patients with polycythemia vera (1)(2)(3)(4) Physical examination revealed an alert, cyanotic, slightly orthopneic man who weighed 290 pounds and was 67 inches in height. A few rales were heard at the right posterior lung base. The heart was in gallop rhythm, and the pulmonic second sound was accentuated. Mild edema of the abdominal wall and marked edema of the lower extremities was present.The significant laboratory findings were as follows: red blood cells 6.77 million per cu. mm.; hemoglobin 20 gm. per cent; hematocrit 69 per cent; white blood cells 6,000 per cu. mm. with a normal differential count and normal cellular morphology; platelets 150,000 per cu. mm. The bone marrow showed hyperplasia of the erythroid series, and reticulocytes were 1 per cent of the red blood cells. The blood uric acid was 9.6 mg. per cent. The urinary 17-ketosteroid excretion was 8 mg. in twenty-four hours (normal). X-ray of the chest showed cardiac enlargement and enlargement of the pulmonary vessels. Angiocardiography showed filling of the cardiac chambers in normal sequence. The sella turcica appeared normal by X-ray. An electrocardiogram showed evidence of right ventricular hypertrophy.

Section: Measurementsmentioning

confidence: 91%

Section: Measurementsmentioning

confidence: 91%

Clinical and Physiological Aspects of a Case of Obesity, Polycythemia and Alveolar Hypoventilation

Jh¹,

Cook²,

Ad³

1955

150

“…and diffusing capacity required simultaneous sampling of expired gas (21). Since adequate normal standards for women are not available, three-fourths of the value for a man of the same age and height was used in the case of female subjects.…”

Section: Clinical Materials and Methodsmentioning

confidence: 99%

The Diffusing Capacity of the Lungs in Patients With Mitral Stenosis Studied Post-Operatively 1

Riley¹,

Johns²,

Cohen³

et al. 1956

Self Cite

The fact that morphological changes occur in the lungs of patients with mitral stenosis has been generally accepted since 1936 when Parker and Weiss described thickening of the capillary basement membrane, scarring and probable loss of capillaries (1). These findings have been confirmed and extended by others (2, 3), yet there is no agreement regarding the physiological and clinical significance of the pulmonary lesions. Because of their location in relation to vascular structures, one would expect that such lesions might interfere with the flow of blood through the lungs or with the diffusion of gases across the pulmonary membrane. Hemodynamic studies by a number of different workers have demonstrated an increase in pulmonary vascular resistance in patients with mitral stenosis (4-10). This paper deals with studies of the diffusion of gases across the pulmonary membrane in a group of patients on whom mitral valvulotomy had been performed.The diffusing capacity for oxygen is the number of ml. of oxygen diffusing across the pulmonary membrane per minute in response to a mean difference of 1 mm. Hg in the partial pressure of oxygen on the two sides of the membrane. It is a function of the thickness, physicochemical structure and area of the surface across which diffusion takes place. The area is related to the area of the walls of all capillaries which are actively involved in gas exchange. Capillaries are not included if

“…3). Increased QC through the pulmonary capillaries during exercise may result in recruitment of additional pulmonary capillaries (47) (25) in their calculations employed data gathered by the steady-state technique which requires the simultaneous measurements of arterial and alveolar 02 tensions and 02 consumption and estimates concerning mixed venous 02 tensions (9,13,48). While the DLO2 resting values from the above studies are comparable to the current studies, the exercise values are substantially greater.…”

Section: Methodsmentioning

confidence: 49%

Alterations in Distribution of Blood Flow to the Lung's Diffusion Surfaces During Exercise

Cross¹,

Gong²,

Kurpershoek³

et al. 1973