I-Maculaweb: A Tool to Support Data Reuse in Ophthalmology

Abstract

This paper intends to present a Web-based application to collect and manage clinical data and clinical trials together in a unique tool. I-maculaweb is a user-friendly Web-application designed to manage, share, and analyze clinical data from patients affected by degenerative and vascular diseases of the macula. The unique and innovative scientific and technological elements of this project are the integration with individual and population data, relevant for degenerative and vascular diseases of the macula. Clinical records can also be extracted for statistical purposes and used for clinical decision support systems. I-maculaweb is based on an existing multilevel and multiscale data management model, which includes general principles that are suitable for several different clinical domains. The database structure has been specifically built to respect laterality, a key aspect in ophthalmology. Users can add and manage patient records, follow-up visits, treatment, diagnoses, and clinical history. There are two different modalities to extract records: one for the patient’s own center, in which personal details are shown and the other for statistical purposes, where all center’s anonymized data are visible. The Web-platform allows effective management, sharing, and reuse of information within primary care and clinical research. Clear and precise clinical data will improve understanding of real-life management of degenerative and vascular diseases of the macula as well as increasing precise epidemiologic and statistical data. Furthermore, this Web-based application can be easily employed as an electronic clinical research file in clinical studies.

Healthcare Associated Infections: An Interoperable Infrastructure for Multidrug Resistant Organism Surveillance

“…Similar systems have been set up and are being used in another region in Italy for a clinical network for human immunodeficiency virus [63] and for ophthalmology [35,64].…”

“…It is responsible for the management of patients' reports, clinical history and profiles and its interfaces are compliant with the Retrieve, Locate and Update Services (RLUS) Release 1 standard [29,33,34]. The HRMS was already adopted in different solutions to monitor patients affected by Congestive Heart Failure (CHF) [24] and to share and re-use clinical data in ophthalmology [35] and in infectiology [31,36]. The second component was the Health Terminology Service (HTS).…”

Standards for the Reuse of Clinical Data in Research: the Connection of the Liguria HIV Network and the CISAI Cohort

“…The LHN technical implementation choices are based on the recommendations by the Electronic Source Data Interchange (eSDI) group. The whole technical structure adopted and the general architectural approach of the developed solution are completely described in [8], while the technical solutions are similar to those described in [9], [10]. In order to fulfill the European General Data Protection Regulation (GDPR) and to assure adequate protection to patients' privacy, only indispensable personal information is managed such as birth date, sex and nationality.…”

Real-Life Management of Diabetic Macular Edema with Dexamethasone Intravitreal Implant: A Retrospective Analysis of Long-Term Clinical Outcomes

“…Data from type 2 diabetic patients with diabetic macular edema and nonproliferative diabetic retinopathy (NPDR), treated with dexamethasone 0.7 mg intravitreal implant (Ozurdex ® , Allergan, Inc., Irvine CA, USA) between June 2015 and June 2018 at an ophthalmologic clinic in Italy (Clinica Oculistica, DiNOGMI, University of Genova, Genova), were retrieved from Imaculaweb, a web-based platform designed to collect clinical information from routine ophthalmologic practice [20]. Both naïve and unresponsive to anti-VEGF therapy patients were included in the study.…”