<i>m-s-m</i> cationic gemini and zwitterionic surfactants – a thermodynamic analysis of their mixed micelle formation

McLachlan, Aleisha A.; Singh, Kulbir; McAlduff, Michael; Marangoni, D. Gerrard; Shortall, Samantha Marisha; Wettig, Shawn D.

doi:10.1039/c9ra09432f

Cited by 16 publications

(6 citation statements)

References 66 publications

(64 reference statements)

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“…Currently, mixed micelles have become increasingly popular. These binary systems have been described for 12-6-12 with nonionic and zwitterionic surfactants [22,48,56]. [52].…”

Section: Discussionmentioning

confidence: 99%

Properties and Applications of Quaternary Ammonium Gemini Surfactant 12-6-12: An Overview

Brycki,

Szulc,

Brycka

et al. 2023

Molecules

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Surfactants are amphiphilic molecules and one of the most versatile products of the chemical industry. They can be absorbed at the air–water interface and can align themselves so that the hydrophobic part is in the air while the hydrophilic part is in water. This alignment lowers the surface or interfacial tension. Gemini surfactants are a modern variety of surfactants with unique properties and a very wide range of potential applications. Hexamethylene-1,6-bis(N-dodecyl-N,N-dimethylammonium bromide) is one such representative compound that is a better alternative to a single analogue. It shows excellent surface, antimicrobial, and anticorrosion properties. With a highly efficient synthetic method and a good ecological profile, it is a potential candidate for numerous applications, including biomedical applications.

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“…Currently, mixed micelles have become increasingly popular. These binary systems have been described for 12-6-12 with nonionic and zwitterionic surfactants [22,48,56]. [52].…”

Section: Discussionmentioning

confidence: 99%

Properties and Applications of Quaternary Ammonium Gemini Surfactant 12-6-12: An Overview

Brycki,

Szulc,

Brycka

et al. 2023

Molecules

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“…The symmetric m-s-m gemini surfactants were synthesized using either the method of Wettig and Verall 52,53 or the recently developed microwave method by Singer et al 62 Structures for the gemini surfactants are given in the Data Section (ESI †). Details concerning the synthesis of the surfactants have been described in our previous papers, [63][64][65] and are also available in the ESI. † All the alcohols used in the present work were obtained from Sigma or TCI America and were the highest quality available (Z98%); no efforts were made to additionally purify the alcohols.…”

Section: Methodsmentioning

confidence: 99%

The partitioning of primary alcohols into the aggregates of gemini amphiphiles determined from diffusion NMR experiments

Morris¹,

El-Gendy²,

MacNeil³

et al. 2023

Phys. Chem. Chem. Phys.

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“…In addition to the aforementioned surface modifications, GNPs can be coated with different materials to enhance the GNPs performance such as Bovine Serum Albumin (156), polyethylene glycol (157), and antibodies (158,159). An alternative approach is also developed as GNRs free of CTAB (160,161), which enhances the suitability of these GNRs for clinical settings.…”

Section: Future Perspectives Through Nanotechnologymentioning

confidence: 99%

Biotherapeutic Antibodies for the Treatment of Head and Neck Cancer: Current Approaches and Future Considerations of Photothermal Therapies

Qaraghuli

2020

Front. Oncol.

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Head and neck cancer (HNC) is a heterogeneous disease that includes a variety of tumors originating in the hypopharynx, oropharynx, lip, oral cavity, nasopharynx, or larynx. HNC is the sixth most common malignancy worldwide and affects thousands of people in terms of incidence and mortality. Various factors can trigger the development of the disease such as smoking, alcohol consumption, and repetitive viral infections. HNC is currently treated by single or multimodality approaches, which are based on surgery, radiotherapy, chemotherapy, and biotherapeutic antibodies. The latter approach will be the focus of this article. There are currently three approved antibodies against HNCs (cetuximab, nivolumab, and pembrolizumab), and 48 antibodies under development. The majority of these antibodies are of humanized (23 antibodies) or human (19 antibodies) origins, and subclass IgG1 represents a total of 32 antibodies. In addition, three antibody drug conjugates (ADCs: telisotuzumab-vedotin, indatuximab-ravtansine, and W0101) and two bispecific antibodies (GBR 1372 and ABL001) have been under development. Despite the remarkable success of antibodies in treating different tumors, success was limited in HNCs. This limitation is attributed to efficacy, resistance, and the appearance of various side effects. However, the efficacy of these antibodies could be enhanced through conjugation to gold nanoparticles (GNPs). These conjugates combine the high specificity of antibodies with unique spectral properties of GNPs to generate a treatment approach known as photothermal therapy. This approach can provide promising outcomes due to the ability of GNPs to convert light into heat, which can specifically destroy cancer cells and treat HNC in an effective manner.

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m-s-m cationic gemini and zwitterionic surfactants – a thermodynamic analysis of their mixed micelle formation

Abstract: Excess enthalpies of micelle formation for the ZW3-12/12-s-12 system as a function of the mole fraction of zwittergent (αZW3-12).

Cited by 16 publications

References 66 publications

Properties and Applications of Quaternary Ammonium Gemini Surfactant 12-6-12: An Overview

Properties and Applications of Quaternary Ammonium Gemini Surfactant 12-6-12: An Overview

The partitioning of primary alcohols into the aggregates of gemini amphiphiles determined from diffusion NMR experiments

Biotherapeutic Antibodies for the Treatment of Head and Neck Cancer: Current Approaches and Future Considerations of Photothermal Therapies

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