m-Chloroperoxybenzoic Acid (MCPBA)

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research

meta-Chloroperbenzoic acid (mCPBA): a versatile reagent in organic synthesis

“…diazoketones, N-substituted phthalimidines, selenides, furans, phosphates, and for N-oxidation. 10 mCPBA can be prepared by the reaction of m-chlorobenzoyl chloride with H 2 O 2 in the presence of MgSO 4 $7H 2 O, aqueous NaOH and dioxane (Scheme 1). 11 mCPBA is easy to handle, ammable, and hygroscopic, and pure mCPBA is shock-sensitive and can deagrate.…”

“…Moreover, it is potentially explosive beyond 85% purity and exhibits 1% degradation per year at room temperature. 10 It is interesting to note that 85% mCPBA is not shock-sensitive, but it should be stored in a refrigerator in a tightly closed container. mCPBA irritates the mucous membranes, respiratory tract, eyes and skin.…”