Lycium barbarumPolysaccharide Mediated the Antidiabetic and Antinephritic Effects in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats via Regulation of NF-κB

Abstract

Lycium barbarum, extensively utilized as a medicinal plant in China for years, exhibits antitumor, immunoregulative, hepatoprotective, and neuroprotective properties. The present study aims to investigate the hyperglycemic and antidiabetic nephritic effects of polysaccharide which is separated from Lycium barbarum (LBPS) in high-fat diet-streptozotocin- (STZ-) induced rat models. The reduced bodyweight and enhanced blood glucose concentration in serum were observed in diabetic rats, and they were significantly normalized to the healthy level by 100 mg/kg of metformin (Met) and LBPS at doses of 100, 250, and 500 mg/kg. LBPS inhibited albuminuria and blood urea nitrogen concentration and serum levels of inflammatory factors including IL-2, IL-6, TNF-α, IFN-α, MCP-1, and ICAM-1 compared with diabetic rats, and it indicates the protection on renal damage. Furthermore, the activities of SOD and GSH-Px in serum were enhanced strikingly by LBPS which suggests its antioxidation effects. LBPS, compared with nontreated diabetic rats, inhibited the expression of phosphor-nuclear factors kappa B (NF-κB) and inhibitor kappa B alpha in kidney tissues. Collectively, LBPS possesses antidiabetic and antinephritic effects related to NF-κB-mediated antioxidant and antiinflammatory activities.

New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis

“…In addition to the five monomers described above, many other monomers are also found to be closely related to the BMID axis, including tetrandrine [ 109 ], notoginsenoside [ 110 ], Lycium barbarum polysaccharide [ 111 ], allicin [ 112 ], astragaloside IV [ 113 , 114 ], quercetin [ 115 ], and resveratrol [ 116 ].…”

Exosomal microRNA Expression Profiling Analysis of the Effects of Lycium Barbarum Polysaccharide on Gestational Diabetes Mellitus Mice

“…Although increasing studies have been conducted on diabetes, very few researches were specifically tailored towards GDM. LBP has been reported to possess beneficial effect on diabetes [21,22]. Given 19b-3p and miR-20a-5p were increased in the plasma of women with GDM [16].…”

“…Previous studies have demonstrated that LBP can improve lipid metabolism profiles in animal and human models [20,21]. Moreover, LBP showed antidiabetic effects in dietstreptozotocin-induced diabetic rats [22] and in patients with type 2 diabetes [23]. However, whether LBP exhibited beneficial effects against GDM is still unclear.…”

Chinese herbal drugs for the treatment of diabetic retinopathy

“…Lycium barbarum (Family Solanaceae), commonly known as Goji berry or Wolfberry, is a popular Chinese traditional plant known to possess several medicinal properties, namely antitumour, antioxidant, anti‐inflammatory, immunoregulatory, anti‐ageing, hepatoprotective, antiglaucoma and neuroprotective. The main phytoconstituents responsible for these actions have been identified as polysaccharides, zeaxanthin, carotene, betaine, cerebroside, beta‐sitosterol, p‐coumaric and various vitamins . However, recent studies have reported L. barbarum‐ mediated clinical antidiabetic potential and protective actions against diabetic complications such as antinephritic and antiretinopathic effects in animal models .…”