<i>Lhr</i>and<i>Hmr</i>are required for sister chromatid detachment during anaphase but not for centromere function

Ja, Blum; Bonaccorsi, Silvia; Marzullo, Marta; Palumbo,; Ym, Yamashita; Da, Barbash; Gatti, Maurizio

doi:10.1101/178046

2017

DOI: 10.1101/178046

|View full text |Cite

Preprint

LhrandHmrare required for sister chromatid detachment during anaphase but not for centromere function

Blum Ja

Silvia Bonaccorsi

Marta Marzullo

et al.

Abstract: Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue (Hmr)

Help me understand this report

View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

Lukacs

Thomae

Krueger

et al. 2021

Preprint

View full text Add to dashboard Cite

Postzygotic isolation by genomic conflict is a major cause for the formation of species. Despite its importance, the molecular mechanisms that result in the lethality of interspecies hybrids are still largely unclear. The genus Drosophila, which contains over 1600 different species, is one of the best characterized model systems to study these questions. We showed in the past that the expression levels of the two hybrid incompatibility factors Hmr and Lhr diverged in the two closely related Drosophila species, D. melanogaster and D. simulans, resulting in an increased level of both proteins in interspecies hybrids. This overexpression leads to mitotic defects, a misregulation in the expression of transposable elements and a decreased fertility. In this work, we describe a distinct six subunit Speciation Core Complex (SCC) containing HMR and LHR and analyse the effect of Hmr mutations on complex function and integrity. Our experiments suggest that HMR acts as a bridging factor between centromeric chromatin and pericentromeric heterochromatin, which is required for both its physiological function and its ability to cause hybrid male lethality.

show abstract

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

Lukacs

Thomae

Krueger

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

LhrandHmrare required for sister chromatid detachment during anaphase but not for centromere function

Abstract: Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue (Hmr)

Cited by 1 publication

References 56 publications

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

Contact Info

Product

Resources

About