<i>Leishmania infantum</i>Infection in Blood Donors, Northeastern Brazil

Monteiro, Daniela Cristina Sensato; Sousa, Anastácio Q.; Lima, Danielle Malta; Fontes, Raissa Matos; Praciano, Claudênia C.; Frutuoso, Mércia S.; Matos, Loraine C.; Teixeira, Maria Jânia; Pearson, Richard D.; Pompeu, Margarida M. L.

doi:10.3201/eid2204.150065

Cited by 13 publications

(4 citation statements)

References 9 publications

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“…The first evaluation revealed infection in 41.4% of blood donors—a surprisingly high rate, not only for Brazil (Salvador: 5.4% of 700; Paraná: 11.4% of 176; Fortaleza: 17.1% of 431) [ 21 – 23 ], but also globally (France: 13.4% of 565; Spain: 3.1% of 1437; Nepal: 1% of 507) [ 24 – 26 ].…”

Section: Discussionmentioning

confidence: 99%

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

et al. 2018

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Transfusion-transmitted leishmaniasis has been a concern in regions endemic for the disease. Whether immediate or delayed, the risks posed by this mode of transmission call for careful assessment. The purpose of this study was to detect Leishmania infection in blood donors living in an endemic area and to investigate progression to the disease in these individuals. Immunofluorescent antibody test, enzyme-linked immunosorbent assay, leishmaniasis rapid test, and the polymerase chain reaction were applied to 430 donors in an initial evaluation. Of those donors with at least one positive test, 50 were reevaluated four years later by the same methods, as were 25 controls who had been negative on the same tests. In the first evaluation, Leishmania infection was detected in 41.4% (95% CI: 36.7–46.1) of donors (n = 430). None of the 75 reevaluated individuals had developed the disease, but retesting revealed positivity in at least one test in 36.0% (95% CI: 25.1–46.9) of donors. Of the 50 initially testing positive, 50% remained so on retesting. Of the 25 initially negative controls, two tested positive in the subsequent evaluation. The severity of the parasitosis and the risk of transfusion transmission warrant investigation of the potential inclusion of methods for Leishmania detection into blood banks for effective screening of infected donors.

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Section: Discussionmentioning

confidence: 99%

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

et al. 2018

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“…Determination of the prevalence of asymptomatic visceral leishmaniasis infection in blood donors is the first step in assessing the risk of transmission by blood transfusion. In the northeast of Brazil, prevalence rates of 9 and 13·2% were reported in blood donors (Luz et al, ; Monteiro et al, ) and 37% in multi‐transfused patients on haemodialysis (Luz et al, ). In Minas Gerais in south‐eastern Brazil, the prevalence among donors was 5·5% (Urias et al, ) and 15·6% in the central‐west region (França et al, ), confirming the high prevalence of asymptomatic infected donors in different regions of the country.…”

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confidence: 99%

Socio‐epidemiological characterisation of blood donors with asymptomatic Leishmania infantum infection from three Brazilian endemic regions and analysis of the transfusional transmission risk of visceral leishmaniasis

Ferreira-Silva

Teixeira

Tibúrcio

et al. 2018

Transfusion Medicine

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“…To minimize the risk of transfusion of Leishmania-infected blood, different pre-storage measures would be used in blood banks, such as leukodepletion and pathogen-reducing technologies, such as ultraviolet light which could decrease the discarding of collected bags considering the current scarcity of blood donation (Monteiro et al, 2016;Jimenez-Marco et al 2018). In this way, we believe that these measures would prevent the exponential increase of HVL through blood transfusion mainly in endemic areas…”

Section: Resultsmentioning

confidence: 99%

Leishmania infantum chagasi detection in blood donors living in an endemic area

Lopes

Florencio-Henschel

Jordão

et al. 2022

Preprint

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Human Visceral Leishmaniasis (HVL) is a neglected disease that occurs in 98 countries on five continents, and it is endemic in tropical and subtropical regions. In South America, the etiological agent of HVL is Leishmania infantum chagasi, mainly transmitted through the bite of an infected sandfly female from the genus Lutzomyia. In American HVL endemic areas, is common the occurrence of asymptomatic infection, which contribute with the possibility of L. infantum chagasi transmission during a blood transfusion. To know the prevalence of L. infantum chagasi asymptomatic infection in blood donors from the microregion of Adamantina, we investigated 324 peripheral blood samples from donors through Immunofluorescence (IFAT) and PCR-RFLP techniques. Seven blood samples (2.16%) tested positive for Leishmania by IFAT, and from that six presented positive results by PCR (85.71%), which were later identified as L. infantum chagasi by RFLP. The presence of L. infantum chagasi in the peripheral blood of blood donors supported the hypothesis of transmission by blood transfusion and points to the need to include tests for visceral leishmaniasis in blood bank screening tests and pre-storage measures, especially in endemic areas to prevent the exponential increase of HVL by blood transfusion.

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Leishmania infantumInfection in Blood Donors, Northeastern Brazil

Cited by 13 publications

References 9 publications

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

Socio‐epidemiological characterisation of blood donors with asymptomatic Leishmania infantum infection from three Brazilian endemic regions and analysis of the transfusional transmission risk of visceral leishmaniasis

Leishmania infantum chagasi detection in blood donors living in an endemic area

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