<i>Legionella pneumophila</i> lung abscess associated with immune suppression

Guy, Stephen; Worth, Leon J; Thursky, Karin; Francis, Prudence A.; Slavin, Monica A

doi:10.1111/j.1445-5994.2011.02508.x

Cited by 22 publications

(11 citation statements)

References 48 publications

(67 reference statements)

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“…Overall risk of infection demonstrated to be higher during the first 6 months of treatment. Patients treated with biologics can initially present with mild symptoms, such as general fatigue even in absence of fever [84]; dyspnea typically occurs after few days. Infection can occasionally result in inappropriate secretion of antidiuretic hormone, which produces hyponatremia.…”

Section: The Most Frequent Opportunistic Lung Infections and Theirmentioning

confidence: 99%

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Franco

Lucchino

Spaziante

et al. 2017

IJMS

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Systemic rheumatic diseases have significant morbidity and mortality, due in large part to concurrent infections. The lung has been reported among the most frequent sites of infection in patients with rheumatic disease, who are susceptible to developing pneumonia sustained both by common pathogens and by opportunistic microorganisms. Patients with rheumatic disease show a peculiar vulnerability to infectious complications. This is due in part to intrinsic disease-related immune dysregulation and in part to the immunosuppressive treatments. Several therapeutic agents have been associated to a wide spectrum of infections, complicating the management of rheumatic diseases. This review discusses the most frequent pulmonary infections encountered in rheumatic diseases, focusing on opportunistic agents, consequent diagnostic challenges and appropriate therapeutic strategies.

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Section: The Most Frequent Opportunistic Lung Infections and Theirmentioning

confidence: 99%

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Franco

Lucchino

Spaziante

et al. 2017

IJMS

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“…Lung abscesses due to L. pneumophila occur rarely, almost exclusively in immunocompromised patients, and may be associated with an increase in mortality (5). Guy et al, reviewing L. pneumophila cavitary pneumonia cases between 1977 and 2008, noticed an association between the use of corticosteroids and the occurrence of lung abscesses (6). To our knowledge, the present report is the first of cavitary lung infection due to L. pneumophila serogroup 10.…”

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confidence: 54%

Answer to January 2017 Photo Quiz

et al. 2017

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“…Corticosteroid therapy and other forms of immunosuppressive agents such as azathioprine have been the cause of predisposition to cavitary L. pneumophila pneumonias. 7 However, when infectious sources have been ruled out, SLE patients with cavitations respond to steroid treatment and cavitations resolve within weeks to months of steroid and immunosuppressive therapy. 8,9…”

Section: Discussionmentioning

confidence: 99%

Legionella pneumophilaas a cause of cavitary lung disease in systemic lupus erythematous

Khokher

Kesireddy

Adunse

et al. 2021

Lupus

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Legionnaire’s disease (LD) is most commonly caused by Legionella pneumophila (L. pneumophila). In immunocompromised patients LD can cause necrosis of the lung parenchyma with abscess formation and cavitation. Systemic lupus erythematosus (SLE) is an autoimmune disorder with features of both primary and secondary immunodeficiency. SLE patients often develop pulmonary abnormalities, but rarely develop lung cavitations. We report a case of cavitary pneumonia caused by L. pneumophila in a 64-year-old female patient with SLE. We also highlight reasons why SLE patients are more prone to L. pneumophila infections. The importance of using correct diagnostic methods for recognizing and treating such infections is also discussed, as mistreatment of cavitary lesions in SLE patients with steroid therapy can have fatal outcomes as the infectious process can significantly worsen.

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Legionella pneumophila lung abscess associated with immune suppression

Cited by 22 publications

References 48 publications

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections

Answer to January 2017 Photo Quiz

Legionella pneumophilaas a cause of cavitary lung disease in systemic lupus erythematous

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