<i>Laser Systems and Applications</i>

Elion, Herbert A.; Hotz, David F.

doi:10.1063/1.3035119

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Introduction1

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1969

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“…In biological investigations, advantage may be taken of the very large local electric fields ( -lo7 v cm-l) created by the focussed &-switched laser beam to produce large potential differences ( -several hundred volts) across transparent biological specimens and thus separate electrical from thermal effekts. A focussed beam may also be used to destroy individual cells or puncture cell-walls on a microscale in genetic studies (Peppers 1965, Elion 1967.…”

Section: Introductionmentioning

confidence: 99%

Intensity distribution of focussed laser beams in bio-medical studies

Evans

Morgan

1969

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Universal numerical solutions for the intensity of laser beams focussed by simple lenses having various amounts of primary spherical aberration have been ohtained and are presented graphically in the form of lines of constant intensity (isophotes). The solutions demonstrate the increasingly non-uniform nature of the isophotes as the lens aberration function is increased. The existence of a multiplicity of intensity maxima, both along the optic axis and in off-axis positions, extending over comparatively large distances (-mm) from the lens Gaussian focus, is disclosed. These must be taken into account in any quantitative assessment of the effects of laser beam radiation upon biological material.

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Section: Introductionmentioning

confidence: 99%