<i>Lactobacillus rhamnosus</i> R0011 Treatment Enhanced Efficacy of Capecitabine against Colon Cancer in Male Balb/c Mice

Rahimpour, Milad; Ashabi, Ghorbangol; Rahimi, Alireza; Halimi, Shahnaz; Panahi, Mahshid; Alemrajabi, Mahdi; Nabavizadeh, Fatemeh

doi:10.1080/01635581.2021.2014901

Cited by 3 publications

(3 citation statements)

References 29 publications

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Section: Probioticsmentioning

confidence: 99%

“…The Lactobacillus rhamnosus probiotic strain increased the effectiveness of the chemotherapeutic agent, capecitabine, in a mouse model of colon cancer if administered prior to inoculation of CT-26 cells [55]. The study indicated that the probiotic not only increased the effectiveness of chemotherapy resulting in reduced tumor size, but also decreased chemotherapy-related adverse effects by preventing reduction in white blood cells, inducing apoptosis through increased caspase-3 levels, and reducing systemic inflammation indicated by decreased IL-6 levels [55]. A randomized, single-blind, placebo-controlled prospective study of 100 colorectal cancer patients showed that those who were given probiotics following surgery indicated a lower gastrointestinal dysbiosis, which improved quality of life and reduced chemotherapy-related malnutrition [56].…”

Section: Probioticsmentioning

confidence: 99%

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Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia

Yoon,

Grundmann

2023

Nutrients

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Cancer cachexia is a multi-organ syndrome with unintentional weight loss, sarcopenia, and systemic inflammation. Gastrointestinal (GI) cancer patients are more susceptible to cachexia development due to impaired nutrient absorption and digestion. Given the widespread availability and relatively low cost of dietary supplements, we examined the evidence and effects of fish oil (omega-3 fatty acids), melatonin, probiotics, and green tea for managing symptoms of GI cancer cachexia. A literature review of four specific supplements was conducted using PubMed, Google Scholar, and CINAHL without a date restriction. Of 4621 available literature references, 26 articles were eligible for review. Fish oil decreased C-reactive protein and maintained CD4+ cell count, while melatonin indicated inconsistent findings on managing cachexia, but was well-tolerated. Probiotics decreased serum pro-inflammatory biomarkers and increased the tolerability of chemotherapy by reducing side effects. Green tea preparations and extracts showed a decreased risk of developing various cancers and did not impact tumor growth, survival, or adverse effects. Among these four supplements, probiotics are most promising for further research in preventing systemic inflammation and maintaining adequate absorption of nutrients to prevent the progression of cancer cachexia. Supplements may benefit treatment outcomes in cancer cachexia without side effects while supporting nutritional and therapeutic needs.

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Section: Probioticsmentioning

confidence: 99%

Section: Probioticsmentioning

confidence: 99%

Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia

Yoon,

Grundmann

2023

Nutrients

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“… 67 However, the modulation of gut microbiome by supplementation of probiotic Lactobacillus rhamnosus R0011 improved the efficacy of capecitabine-based chemotherapy, which has been recently shown in an animal model (male Balb/c mice, colon cancer) study. 68 The impact of prebiotics (xylo-oligosaccharides) on gut microbiota, side effects, and drug (capecitabine) bioavailability in the case of colorectal cancer patients is under investigation. 69 In Guan et al .…”

Section: Anti-metabolites Specific For S Phasementioning

confidence: 99%

Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?

Kaźmierczak-Siedlecka,

Bulman,

Ulasiński

et al. 2023

Gut Microbes

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Intestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotransformation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively gathered scientific evidence on the interplay between anticancer therapies and gut microbes. We also underlined how such interactions might impact the host response to a given therapy. We discuss the possibility of modulating the gut microbiota to increase the effectiveness/decrease the incidence of adverse events during tumor therapy. The anticipation of the future brings new evidence that gut microbiota is a target of interest to increase the efficacy of therapy.

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Crosstalk between gut microbiota and RNA N6-methyladenosine modification in cancer

Cheung

Lau

et al. 2023

FEMS Microbiology Reviews

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The gut microbiota plays a crucial role in regulating various host metabolic, immune, and neuroendocrine functions, and has a significant impact on human health. Several lines of evidence suggest that gut dysbiosis is associated with a variety of diseases, including cancer. The gut microbiota can impact the development and progression of cancer through a range of mechanisms, such as regulating cell proliferation and death, modulating the host immune response, and altering the host metabolic state. Gene regulatory programs are considered critical mediators between the gut microbiota and host phenotype, of which RNA N6-methyladenosine (m6A) modifications have attracted much attention recently. Aberrant m6A modifications have been shown to play a crucial role in cancer development. This review aims to provide an overview of the diverse roles of gut microbiota and RNA m6A modifications in cancer and highlight their potential interactions in cancer development.

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Lactobacillus rhamnosus R0011 Treatment Enhanced Efficacy of Capecitabine against Colon Cancer in Male Balb/c Mice

Cited by 3 publications

References 29 publications

Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia

Relevance of Dietary Supplement Use in Gastrointestinal-Cancer-Associated Cachexia

Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?

Crosstalk between gut microbiota and RNA N6-methyladenosine modification in cancer

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