Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure

Colon-targeted Engineered Postbiotics Nanoparticles Alleviating Osteoporosis through Gut-Bone Axis

“…5m) and ZO-1 (Fig. 5n), which indicated impaired intestinal integrity as previous reported 29 . Notably, the B@S treatment was able to rescue the levels of claudin-1 and ZO-1 signi cantly.…”

“…These results illustrated that B@S could induce obvious impacts on promoting osteoblastic bone formation and inhibition of osteoclastic bone resorption in OVX mice. Previous studies concluded that estrogen de ciency impaired intestinal integrity, accompanied by an elevation of systemic in ammation, disrupting bone metabolism 29 . Thus, we analyzed the intestinal barriers of B@S-treated OVX mice histologically (Fig.…”

Bifidobacterium improves oestrogen-deficiency-induced osteoporosis in mice by modulating intestinal immunity

“…21 However, the specific mechanisms by which gut immunity influences bone health are not yet fully understood. 12,13,22–25 In this study, we found that B. bifidum FL228.1 and B. animalis F1–7 significantly inhibited bone loss in OVX mice by improving the inflammatory condition in the intestine. The main mechanism of the two probiotics involved the maintenance of the intestinal barrier and correction of intestinal microbiome disturbances.…”

“…Similarly, another study has reported that OVX leads to an increase in IL-17A and TNF-α levels in the intestines. 24 Treatment with B. bifidum FL228.1 and B. animalis F1–7 resulted in varying degrees of inhibition of the expression of colonic inflammatory cytokines, leading to a reduction in intestinal inflammation. 30 Therefore, it can be inferred that B. bifidum FL228.1 and B. animalis F1–7 alleviate bone loss by reducing the formation of osteoclasts through the suppression of inflammatory cytokines in the intestines.…”

Synthetic biology‐based bacterial extracellular vesicles displaying BMP‐2 and CXCR4 to ameliorate osteoporosis

“…OP is mainly caused by the imbalance of bone‐forming and bone‐resorbing (Guo et al., 2023). Despite the widely applied anti‐resorptive agents (such as bisphosphonates (Rachner et al., 2011) and denosumab (Bone et al., 2017) and anabolic drugs (such as parathyroid hormone (Neer et al., 2001), innovative treatment strategy to regulate the osteoblasts‐osteoclasts balance are emphasized (Zhou et al., 2021).…”