<i>Lactobacillus rhamnosus</i>from human breast milk ameliorates ulcerative colitis in mice<i>via</i>gut microbiota modulation

Pang, Bing; Han, Jing; Liao, Ning; Li, Junjun; Jiang, Chunmei; Shao, Dongyan; Shi, Junling

doi:10.1039/d0fo03479g

Cited by 37 publications

(41 citation statements)

References 68 publications

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“…Here, DSS treatment also changed the composition of the bacteria community in comparison with the control group; we reviewed the literature and found that it is a common phenomenon. [ 7,46,47 ] It is understandable because DSS may somehow affect the bacteria community, and on the other hand, colitis is always accompanied by microbiota alteration. [ 48 ] The general enterobacteria composition of each sample at the phylum and family level (Figure 5c,d) was shown by bar chart and heatmap, respectively.…”

Section: Resultsmentioning

confidence: 99%

Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora

et al. 2021

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Intestinal immune homeostasis and microbiome structure play a critical role in the pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment remains a challenge as the first-line drugs show limited therapeutic efficiency and great side effect. In this study, a colon-targeted adhesive core-shell hydrogel microsphere is designed and fabricated by the ingenious combination of advanced gas-shearing technology and ionic diffusion method, which can congregate on colon tissue regulating the gut immune-microbiota microenvironment in IBD treatment. The degradation experiment indicates the anti-acid and colon-targeted property of the alginate hydrogel shell, and the in vivo imaging shows the mucoadhesive ability of the thiolated-hyaluronic acid hydrogel core of the microsphere, which reduces the systematic exposure and prolongs the local drug dwell time. In addition, both in vitro and in vivo study demonstrate that the microsphere significantly reduces the secretion of pro-inflammatory cytokines, induces specific type 2 macrophage differentiation, and remarkably alleviates colitis in the mice model. Moreover, 16S ribosomal RNA sequencing reveals an optimized gut flora composition, probiotics including Bifidobacterium and Lactobacillus significantly augment, while the detrimental communities are inhibited, which benefits the intestinal homeostasis. This finding provides an ideal clinical candidate for IBD treatment.

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Section: Resultsmentioning

confidence: 99%

Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora

et al. 2021

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“…20 In general, the UC-attenuating effects of probiotics are mainly due to (1) preventing the colonization of pathogenic bacteria via competing for common receptors or nutrients and (2) inhibiting the growth of pathogenic bacteria by producing organic acid, bacteriocin, or antitoxin proteases, so as to modulate intestinal microbiota, enhance the gut barrier function, regulate metabolism, or suppress inflammation. 19,21 Nevertheless, the clinical application of probiotics to ameliorate UC is still limited because the species-specific effects of probiotics may cause different clinical effects. Therefore, it is necessary to explore some new probiotics with UC-ameliorating effects and study their mechanisms.…”

Section: ■ Introductionmentioning

confidence: 99%

Protective Effects of Companilactobacillus crustorum MN047 against Dextran Sulfate Sodium-Induced Ulcerative Colitis: A Fecal Microbiota Transplantation Study

Wang

Shi

Wang

et al. 2022

J. Agric. Food Chem.

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Gut microbiota dysbiosis could aggravate the development of ulcerative colitis (UC). Companilactobacillus crustorum MN047 (CCMN) is a potential gut microbiota-regulating probiotic that could produce multiple novel bacteriocins. In this study, fecal microbiota transplantation (FMT) was used to verify whether CCMN could alleviate dextran sulfate sodium-induced UC by regulating gut microbiota. Results showed that both CCMN and FMT ameliorated the symptoms of UC, including attenuating the increased disease activity index, shortened colon length, gut barrier damage, and inflammation. Briefly, CCMN and FMT upregulated the expressions of MUCs and tight junctions, downregulated the expressions of proinflammatory cytokines and chemokines, increased fecal short-chain fatty acids, and lowered serum lipopolysaccharides, which were associated with the regulation of gut microbiota (e.g., increased Akkermansia, Blautia, and Ruminococcus levels). These results demonstrated that CCMN could ameliorate UC by modulating gut microbiota and inhibiting the TLR4/NF-κB pathway. Therefore, CCMN could be considered as a potential probiotic supplement for ameliorating UC.

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Ulcerative colitis (UC), belonging to chronic inflammatory bowel disease (IBD), has increasing morbidity (Pang et al, 2021), especially in the developing countries (Nascimento et al, 2020). UC is a frequently-occurring disease between the age of 30 and 40 (Armuzzi & Liguori, 2021) and is characterized by a long disease course and repeated attacks.

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confidence: 99%

Oral administration of octacosanol modulates the gut bacteria and protects the intestinal barrier in ulcerative colitis mice

Miao

Zhou

et al. 2022

Journal of Food Biochemistry

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Ulcerative colitis (UC), belonging to chronic inflammatory bowel disease (IBD), has increasing morbidity (Pang et al., 2021), especially in the developing countries (Nascimento et al., 2020). UC is a frequently-occurring disease between the age of 30 and 40 (Armuzzi & Liguori, 2021) and is characterized by a long disease course and repeated attacks. UC patients may suffer from bloody stool and diarrhea (Armuzzi & Liguori, 2021), furthermore, UC is not only a physical disease, but also cause psychiatric disorders, such as depression, anxiety, and fatigue (Nowakowski et al., 2016). Currently, aminosalicylic acid preparations (e.g., mesalazine, sulfasalazine), corticosteroids (e.g., prednisolone), immunosuppressants, and biological agents are the most typical drugs for UC. However, the safety, efficacy, and expensive

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Lactobacillus rhamnosusfrom human breast milk ameliorates ulcerative colitis in miceviagut microbiota modulation

Abstract: L. rhamnosus SHA113 (LRS) relieves ulcerative colitis (UC) via the regulation of gut microbiota.

Cited by 37 publications

References 68 publications

Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora

Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora

Protective Effects of Companilactobacillus crustorum MN047 against Dextran Sulfate Sodium-Induced Ulcerative Colitis: A Fecal Microbiota Transplantation Study

Oral administration of octacosanol modulates the gut bacteria and protects the intestinal barrier in ulcerative colitis mice

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