<i>Lactobacillus plantarum</i>
            Lp62 exerts probiotic effects against
            <i>Gardnerella vaginalis</i>
            ATCC 49154 in bacterial vaginosis

Selis, Nathan Neves; Oliveira, Pollianna S.; Souza, Cláudio Lima; Almeida, Jéssica Bomfim de; Andrade, Yasmin M.F.S.; Silva, L.S.C.; Romano, Carla Cristina; Rezende, Rachel Passos; Yatsuda, Regiane; Uetanabaro, Ana Paula Trovatti; Marques, Lucas Miranda

doi:10.1111/lam.13547

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…In a meta-analysis of 30 studies ( Jeng et al., 2020 ), BV patients were followed up after treatment and found that probiotic intervention reduced the recurrence rate of vaginitis (OR = 0.27, 95% CI: 0.18-0.41, P<0.001), Improve the cure rate of vaginitis (OR = 2.28, 95% CI: 1.20-4.32, P = 0.011). ( Selis et al. (2021) proved through in vitro experiments that Lactobacillus plantarum Lp62 and its supernatant could significantly inhibit the growth of Gardnerella .…”

Section: Effects Of Probiotics On Bvmentioning

confidence: 99%

“…In a meta-analysis of 30 studies (Jeng et al, 2020), BV patients were followed up after treatment and found that probiotic intervention reduced the recurrence rate of vaginitis (OR = 0.27, 95% CI: 0.18-0.41, P<0.001), Improve the cure rate of vaginitis (OR = 2.28, 95% CI: 1.20-4.32, P = 0.011). (Selis et al, (2021) proved through in vitro experiments that Lactobacillus plantarum Lp62 and its supernatant could significantly inhibit the growth of Gardnerella. In another meta-analysis of 18 studies (Liu and Yi, 2022) with 3-month follow-up, the combination of antibiotics and probiotics was found to significantly reduce the recurrence rate of BV compared with antibiotics alone.…”

Section: Effects Of Probiotics On Bvmentioning

confidence: 99%

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The role of probiotics in vaginal health

Mei¹,

2022

Front. Cell. Infect. Microbiol.

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Probiotics have been widely used in the treatment of intestinal diseases, but the effect of probiotics on female reproductive tract health is still controversial. Lactobacillus is the most abundant microorganism in the vagina, which is related to the vaginal mucosal barrier. Lactobacillus adheres to the vaginal epithelium and can competitively antagonize the colonization of pathogens. The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer. We review the research progress of probiotics represented by Lactobacillus in gynecological diseases such as human papilloma virus (HPV) infection, bacterial vaginosis (BV) and Genitourinary Syndrome of Menopause (GSM), so as to provide basis for further exerting the role of probiotics in women’s health.

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Section: Effects Of Probiotics On Bvmentioning

confidence: 99%

Section: Effects Of Probiotics On Bvmentioning

confidence: 99%

The role of probiotics in vaginal health

Mei¹,

2022

Front. Cell. Infect. Microbiol.

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“…Однак значне збільшення нормальної вагінальної флори після лікування пробіотиками спо-стерігалося лише при БВ (сукупне СШ 4,55; 95% ДІ: 1,44-14,35; р=0,01). N. N. Selis et al (2021) за допомогою експериментів in vitro довели, що L. plantarum Lp62 і його супернатант можуть суттєво пригнічувати ріст Gardnerella [43].…”

Section: г і н е к о л о г і яunclassified

Lactobacilli and lactic acid in maintaining and restoring women’s health

Nosenko,

Demidchik

2023

RHW

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The review article presents modern data on the vaginal microbiota as a component of the female microbiome in normal and pathological conditions. The compositions of different types of vaginal community and their role in ensuring women’s health are described. It is emphasized that lactobacilli, including L. crispatus, L. gasseri, L. jensenii, L. vaginalis, L. iners, are associated with healthy vaginal microbiota, while L. iners is also related to transitional and dysbiotic stages.All types of lactobacilli produce lactic acid, acetic acid and hydrogen peroxide, and maintain a vaginal pH of less than 4.5, inhibit the growth of pathogenic bacteria and excessive Candida albicans and, therefore, protect against the pathogens of bacterial vaginosis and vaginal candidiasis.The article provides data on the key role of lactic acid as a microbicidal and virulicidal factor with immunomodulatory activity. The role of colonization resistance of the vagina is highlighted. The importance of dysbiotic states of the vaginal microbiota in the development of adverse consequences for women’s health was analyzed.Existing methods of treatment of dysbiotic conditions of the vagina are described, which include such antibiotics as metronidazole, clindamycin, estrogen therapy, lactic and boric acids, probiotics, and transplantation of vaginal microbiota. Traditional antibacterial therapy for bacterial vaginosis with metronidazole or clindamycin does not always provide high efficacy in the long term, and there is a high rate of recurrence and cases of vaginal candidiasis after treatment.Systemic use of antibiotics has significant side effects. New strategies help improve treatment outcomes. The use of probiotics can improve the vaginal flora, increase the number of beneficial bacteria, reduce the number of harmful bacteria and further maintain the stability of the vaginal flora environment.The article also describes the advantages of a vaginal probiotic, which is a complex preparation that includes the most common, identical live lactobacilli in high concentration in combination with lactic acid, as an effective modern local support and preventive agent for dysbiotic conditions of the cervical and vaginal microbiota.

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