<i>Lactobacillus plantarum</i> C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis

Jeong, Jin-Ju; Lee, Hae-Ji; Jang, Se-Eun; Han, Myung Joo; Kim, Dong-Hyun

doi:10.1080/09540105.2017.1418841

Cited by 17 publications

(26 citation statements)

References 38 publications

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“…Prevotella could activate Toll-like receptor 2, promoting the secretion of Th17-polarizing cytokines such as IL-23 and IL-6. Turicibacter was considered the pro-inflammatory taxa in chronic inflammatory disease [ 41 , 42 ]. Ruminococcus promoted the Th17 cells differentiation and disrupted the Treg/Th17 balance, while Lactobacillus exerted opposite function [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

Lin

Liu

et al. 2021

J Transl Med

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Background Constipation is a common gastrointestinal dysfunction which has a potential impact on people's immune state and their quality of life. Here we investigated the effects of constipation on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Methods Constipation was induced by loperamide in female C57BL/6 mice. The alternations of gut microbiota, permeability of intestinal barrier and blood–brain barrier, and histopathology of colon were assessed after constipation induction. EAE was induced in the constipation mice. Fecal microbiota transplantation (FMT) was performed from constipation mice into microbiota-depleted mice. Clinical scores, histopathology of inflammation and demyelination, Treg/Th17 and Treg17/Teff17 imbalance both in the peripheral lymphatic organs and central nervous system, cytokines include TGF-β, GM-CSF, IL-10, IL-17A, IL-17F, IL-21, IL-22, and IL-23 in serum were assessed in different groups. Results Compared with the vehicle group, the constipation mice showed gut microbiota dysbiosis, colon inflammation and injury, and increased permeability of intestinal barrier and blood–brain barrier. We found that the clinical and pathological scores of the constipation EAE mice were severer than that of the EAE mice. Compared with the EAE mice, the constipation EAE mice showed reduced percentage of Treg and Treg17 cells, increased percentage of Th17 and Teff17 cells, and decreased ratio of Treg/Th17 and Treg17/Teff17 in the spleen, inguinal lymph nodes, brain, and spinal cord. Moreover, the serum levels of TGF-β, IL-10, and IL-21 were decreased while the GM-CSF, IL-17A, IL-17F, IL-22, and IL-23 were increased in the constipation EAE mice. In addition, these pathological processes could be transferred via their gut microbiota. Conclusions Our results verified that constipation induced gut microbiota dysbiosis exacerbated EAE via aggravating Treg/Th17 and Treg17/Teff17 imbalance and cytokines disturbance in C57BL/6 mice.

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Section: Discussionmentioning

confidence: 99%

Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

Lin

Liu

et al. 2021

J Transl Med

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“…Inflammatory processes are involved in pathogenic mechanisms in retinal diseases such as AMD and diabetic retinopathy. NF-κB is a central player in the regulation of inflammatory reactions in various types of cells and it is induced by a wide range of chemical and biological stimuli (Debnath, Kim, Nath, & Lee, 2017;Jeong, Lee, Jang, Han, & Kim, 2018). Upon stimulation, NF-κB dissociates from the complex (NF-κB-IκB), translocates into the nucleus and subsequently enhances the transcriptional activation of target genes including IL-6, iNOS, TNF-α and COX-2 (Baldwin, 1996).…”

Section: Discussionmentioning

confidence: 99%

Bilberry anthocyanin-rich extract protects against retinal photooxidative damage via activation of HO-1 and inhibition of NF-κB

Wang

Guo

Sun

et al. 2019

Food and Agricultural Immunology

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Bilberry anthocyanins are functional ingredients for preventing retinal degeneration. This study was to determine whether the molecular mechanism of bilberry anthocyanin-rich extract (BAE) protection of retinal pigment epithelial (RPE) cells and retina against photooxidative damage via heme oxygenase-1 (HO-1) upregulation in vitro and in vivo. Results shown that BAE protected ARPE-19 cells from visible light-induced damage, reduced the intracellular reactive oxygen species levels, and up-regulated the expression of HO-1. Pigmented rabbits were treated with BAE (250 and 500 mg/kg/day) for 2 weeks pre-illumination and 1 week postillumination until sacrifice. The expression of HO-1 in the retina was up-regulated after BAE treatment. BAE significantly suppressed the photooxidation-induced increase in expression of interleukine-6 protein. BAE also attenuated the expression of inflammationrelated gene nuclear factor kappa B (NF-κB). Thus, BAE reduced retinal photooxidative damage through activating the HO-1 expression and suppressing NF-κB activation. ARTICLE HISTORY

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“…Furthermore, Lactobacillus has been shown to modulate maturation of dendritic cells (DCs), thereby promoting T helper (Th) cell differentiation (18,19). Lactobacillus has been reported to ameliorate DSS and TNBS colitis by enhancing CD4 + FoxP3 + regulatory T cells in mesenteric lymph nodes and decreasing pro-inflammatory cytokines in Peyer's patches by regulating Th1-Th2-Th17 cell balance (20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

The Panda-Derived Lactobacillus plantarum G201683 Alleviates the Inflammatory Response in DSS-Induced Panda Microbiota-Associated Mice

Zhou

Duan²,

Zeng

et al. 2021

Front. Immunol.

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Intestinal diseases are one of the main causes of captive giant panda death. Their special dietary habits and gastrointestinal tract structure often lead to intestinal epithelium damage and secondary intestinal infection. The captive giant panda is predisposed to suffer from microbiota dysbiosis due to long-term artificial feeding and antibiotic misuse. However, there are few reported probiotics to treat giant panda enteritis and the associated dysbiosis. This study aims to elucidate the mechanism by which Lactobacillus plantarum G201683 (L. plantarum G83), a promising panda-derived probiotic, exerts a protective effect on intestinal inflammation in the dextran sulfate sodium- (DSS) induced panda microbiota-associated (DPMA) mouse model. The DPMA mouse was generated by antibiotic treatment and 5% DSS drinking water administration to assess the effect of L. plantarum G83 on intestinal inflammation and microbiota in vivo. Our results demonstrated the successful generation of a DPMA mouse model with Enterobacteriaceae enrichment, consistent with the giant panda intestinal microbiota. L. plantarum G83 decreased clinical and histological severity of intestinal inflammation, enhanced intestinal tight junction protein expression (ZO-1, Occludin) and alleviated inflammatory cytokine production (TNF-) in the colon of DPMA mice. The administration of L. plantarum G83 altered the microbiota composition by decreasing pathogen associated taxa such as E. coli and increasing abundance of beneficial bacteria including Bifidobacterium spp. These changes in microbiota composition were associated with an increased concentration of short chain fatty acids (SCFA), reduced NF-κB signaling, and an altered balance of T helper cell subsets. Our findings support L. plantarum G83 as a promising probiotic to treat intestinal inflammation in the giant panda.

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Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis

Cited by 17 publications

References 38 publications

Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

Bilberry anthocyanin-rich extract protects against retinal photooxidative damage via activation of HO-1 and inhibition of NF-κB

The Panda-Derived Lactobacillus plantarum G201683 Alleviates the Inflammatory Response in DSS-Induced Panda Microbiota-Associated Mice

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