<i>Lactobacillus plantarum</i>
            299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease

Malik, Mobin; Suboc, Tisha; Tyagi, Sudhi; Salzman, Nita H.; Wang, Jingli; Rong, Yuluo; Tanner, Michael; Kakarla, Mamatha; Baker, John E.; Widlansky, Michael E.

doi:10.1161/circresaha.118.313565

Cited by 151 publications

(131 citation statements)

References 66 publications

(60 reference statements)

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“…Many studies have revealed that Lactobacillus has the potential to regulate host immune systems, enhance gut metabolic capacities and maintain balance in the gut microbiota (Hou, Zeng, Yang, Liu, & Qiao, ; Zhang et al, ). Lactobacillus plantarum is considered an excellent probiotic in the gastrointestinal tracts of humans and animals and performs important probiotic actions, such as inhibiting Escherichia coli ‐induced intestinal permeability, reducing the incidence of Clostridium difficile , alleviating oxidative damage to the liver, improving growth performance and increasing intestinal immunity and anti‐inflammatory properties (de Vries, Vaughan, Kleerebezem, & de Vos, ; Dudzicz, Kujawa‐Szewieczek, Kwiecien, Wiecek, & Adamczak, ; Fak, Ahrne, Molin, Jeppsson, & Westrom, ; Herías et al, ; Khanian, Karimi‐Torshizi, & Allameh, ; Malik et al, ; Wullt, Johansson Hagslatt, Odenholt, & Berggren, ). Researches have shown that oral administration of L. plantarum can improve the immune responses and enhance the intestinal barrier function of weaning piglets (Wang, Ji, et al, ; Yang, Jiang, Zheng, Wang, & Yang, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Wang

Sun

et al. 2019

Animal Physiology Nutrition

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This study investigated the effect of Lactobacillus plantarum strain 299v on gut health in suckling piglets. Sixty newborn piglets were assigned to control and probiotic treatments, with three litters per treatment (ten piglets/litter). From days 1 to 20 of life, piglets were orally administered a placebo of 0.1% peptone or 1.0 × 1010 CFU L. plantarum 299v daily. Six piglets per treatment were sacrificed on day 20, and intestinal tissues (including duodenum, jejunum, ileum and colon) and the intestinal contents from colon segments were collected. The results demonstrated that piglets treated with L. plantarum 299v had a lower diarrhoea incidence than the controls. L. plantarum 299v administration significantly increased the ratio of the villus height to the crypt depth in the jejunum and ileum, as well as the mRNA expression of jejunal occludin and ileal zonula occludens 1 (ZO‐1). The L. plantarum treatment also increased the mRNA abundance of porcine β‐defensin 2 (pBD2) and pBD3 in the jejunum and ileum and of toll‐like receptors (TLRs), such as TLR2, TLR4, TLR6 and TLR9 in the ileum, and significantly upregulated the mRNA abundances of ileal pBD1 and colonic TLR4. Additionally, the L. plantarum 299v treatment significantly changed the structure of the colonic microbiota, as evidenced by the obvious increases in the relative abundances of the phyla Firmicutes and Actinobacteria and of the genus Lactobacillus. Our findings indicate that L. plantarum 299v facilitates the gut health of suckling piglets, probably by improving the intestinal morphology and intestinal barrier function and by modifying the structure of the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Wang

Sun

et al. 2019

Animal Physiology Nutrition

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“…The sequencing of 16S ribosomal RNA (rRNA)-encoding gene of fecal samples was performed as described previously [15]. Feces from 3 aged rats (22-24 months old) with increased AF susceptibility residing and from young rats (2-3 months old) were collected and the samples were pooled by group.…”

Section: Methodsmentioning

confidence: 99%

Age-Related Changes in the Gut Microbiota Promote Atrial Fibrillation

Zhang¹,

Zhang²,

Luo³

et al. 2020

Preprint

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Background: Aging is the most significant contributor to the increasing prevalence of atrial fibrillation (AF). The gut microbiota dysbiosis is involved in age-associated diseases. However, whether age-associated gut microbial dysbiosis contributes to AF is still unknown. The aim of this study was to evaluate the effect of gut microbiota on the susceptibility of aging-induced AF and to elucidate the underlying mechanisms. Results: The gut microbiota profiling of fecal samples in aged (22-24 months old) and young (2-3 months old) rats was performed by 16S ribosomal RNA gene analysis. A rat model of fecal microbiota transplantation (FMT) was established for analyzing the possible role of age-associated gut microbial dysbiosis in AF. Here, we found that aging process led to marked shift of the microbiota spectrum. The microbiota in young rats following FMT resembled that of aged microbiota and transmitted the increased AF susceptibility by elevation of circulating lipopolysaccharide (LPS). The mechanism for LPS-driven atrial pro-arrhythmic action was dependent on the activation of atrial nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing (NLRP3)-inflammasome. Inhibition of inflammasome by MCC950 resulted in lower atrial fibrosis and AF susceptibility. In addition, atrial fibrosis, plasma LPS concentration, plasma glucose to oral glucose tolerance test (OGTT), intestinal permeability, and gut pathology were significantly increased in elderly human subjects. Finally, altering the microbiota in aged recipient to resemble that of young restored the intestinal barrier dysfunction and LPS and impaired glucose tolerance, and the worse outcomes of aged dysbiosis on atrial fibrosis and AF susceptibility were abrogated. Conclusions: These data suggest that age-associated microbial dysbiosis induces circulating LPS and impairs glucose tolerance, and thereby promotes AF susceptibility through enhanced activity of atrial NLRP3-inflammasome.

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“…2E). Lactobacillus is a probiotic which plays an important role in human health [25,26]. Thus, studying the interactions of this genus with other genera could provide insight into the functions of these species in the development of POF.…”

Section: Microbial Profilingmentioning

confidence: 99%

Changes in the vaginal microbiota associated with primary ovarian failure

Wang

Han

et al. 2020

Preprint

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BackgroundPrimary ovary failure (POF) is defined as follicular failure in women of reproductive age. Although many factors are speculated to contribute to the occurrence of POF, the exact aetiology is unclear.Alterations in the microbiome of women with POF are poorly studied; MethodsThis study investigated the vaginal microbiota of 22 patients with POF and 29 healthy individuals.High-throughput Illumina Miseq sequencing targeting the V3-V4 region of the 16S ribosomal RNA (rRNA) gene was used to evaluate the relationships between vaginal flora and clinical characteristics of POF. ResultsDifferent from before, we found the diversity and richness of the vaginal flora of patients with POF was significantly different to that of healthy controls. Comparison of the flora of patients POF with that of menopausal women revealed that the relative abundance of Lactobacillus was significantly reduced in the latter, and women with reduced relative abundance of Lactobacillus in microbiota community decreased the pregnancy success rate at term. This study confirms that vaginal microbiota dysbiosis occurs in patients with POF. Additionally, the vaginal microbiota is closely related to clinical characteristics of POF and the inclusion of a disease verification model could reveal more accurate information related to the composition of the microbiota and its functions. ConclusionThe result suggests the present study enabled identification of microbiota associated with POF, further investigations of differences in the microbiota in the context of POF will improve our understanding of the pathogenesis of the disease which involve modification of the vaginal microbiota.

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Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease

Cited by 151 publications

References 66 publications

Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets

Age-Related Changes in the Gut Microbiota Promote Atrial Fibrillation

Changes in the vaginal microbiota associated with primary ovarian failure

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