Lactobacillus paracaseiinfluences the gut-microbiota-targeted metabolic modulation of the immune status of diarrheal mice

Abstract

Lactobacillus paracasei from koumiss can enhance the integrity of intestinal mucosal barrier by changing intestinal flora and metabolites.

Exopolysaccharides and Surface-Layer Proteins Expressed by Biofilm-State Lactiplantibacillus plantarum Y42 Play Crucial Role in Preventing Intestinal Barrier and Immunity Dysfunction of Balb/C Mice Infected by Listeria monocytogenes ATCC 19115

“…5,6 Numerous in vitro and in vivo studies have demonstrated that probiotic supplementation can mediate Toll-like receptors to stimulate the expression of tight junction proteins between intestinal epithelial cells, thereby enhancing intestinal barrier function and positively affecting the maintenance of intestinal homeostasis. 7,8 In recent years, a growing number of studies have found that the surface substances of probiotics and their metabolites have a crucial impact on host health. 9 It has been reported that the surface substances of probiotics, such as capsular polysaccharides, surface proteins, and lipophosphati-dic acid, can enhance the intestinal barrier function by specifically binding to Toll-like receptors and activating signaling pathways of NF-κB and MAPK.…”