<i>Lactobacillus paracasei</i> HY7015 Promotes Hair Growth in a Telogenic Mouse Model

Nam, Woo Dong; Kim, Hyeonji; Bae, Chuhyun; Kim, Ji-Soo; Nam, Bora; Kim, Joo-Yun; Park, Soo-Dong; Lee, Jung-Lyoul; Sim, Jae-Il

doi:10.1089/jmf.2020.4860

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…Therefore, it is necessary to identify safe substitutes that promote hair growth and prevent hair loss in humans. In a previous study, we confirmed that the probiotic HY7015 can promote hair growth through angiogenesis supplying essential nutrients around cells in the blood flow [ 14 ]. In this study, we tested another natural product that promotes hair growth in a similar way to HY7015 and found that it can act together with probiotics to improve hair growth.…”

Section: Discussionsupporting

confidence: 55%

“…In addition, Lactobacillus species also affect hair growth: Lactobacillus plantarum expresses vascular endothelial growth factor (VEGF) and keratinocyte growth factor (KGF), which contribute to hair growth in vitro and in vivo [ 11 , 12 , 13 ]. Additionally, Lactobacillus paracasei HY7015 (HY7015), which investigates in this study, promotes secretion of hair growth factors in hair follicle dermal papilla cells and telogenic C57BL/6 mice [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

Lee

Kim

et al. 2022

Molecules

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Hair loss is a disease that requires accurate diagnosis and type-specific medical treatment. Many hair loss treatments have some side effects, such as hormone-related effects, so there is a need for safe and effective hair loss treatment. In this study, we investigated the effects of Lactobacillus paracasei HY7015 (HY7015) and Lycopus lucidus Turcz. (LT) extract on hair regrowth and protection. In vitro experiments were conducted to assess the effects of HY7015 and/or LT extract on human follicle dermal papilla cells (HFDPC) of cytoprotective functions such as proliferations, antioxidants, anti-inflammatory, and growth factor expressions. In animal experiments, we investigated hair regrowth rate, hair follicle formation and secretion of growth factors in telogenic C57BL/6 mice. We confirmed the cytoprotective effects of HY7015 and LT through regulations of proliferation, SOD and IL-1β in HFDPC. In mouse experiments, oral administration of HY7015 and LT promoted hair regrowth as well as hair follicle maturation in the dermal skin of C57BL/6 mice, and upregulated VEGF and IGF-1 growth factor levels in mouse serum. In summary, our data demonstrate that ingestions of HY7015 and LT can promote hair regrowth by enhancing cytoprotective effects and expressions of growth factors.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

Lee

Kim

et al. 2022

Molecules

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“…The interaction between the intestinal microbiota and host has been reported to influence hair status in humans, highlighting the existence of an intestinal microbiota–skin axis that impacts various skin conditions, including alopecia areata ( Mahmud et al, 2022 ). Confirming this, earlier investigations have found that dysbiosis of intestinal microbiota induced alopecia through the overgrowth of Lactobacillus murinus in mice ( Hayashi et al, 2017 ), and that Lactobacillus paracasei HY7015 fostered hair growth within a telogenic mouse model ( Nam et al, 2021 ). Additionally, the intestinal microbiota plays a role in nutrient digestion and utilization, factors that eventually affect hair health ( Yadav and Jha, 2019 ).…”

Section: Introductionmentioning

confidence: 55%

“…The significance of hair coat status and its impact on cattle are well-known; however, the underlying mechanisms that influence hair coat status remain largely unexplored. Recent research has revealed that gut microbiota, operating in symbiosis with their hosts, can impact hair status in humans ( Mahmud et al, 2022 ) and in mice ( Hayashi et al, 2017 ; Nam et al, 2021 ). This information may provide insight for further exploration into the mechanisms influencing hair coat status in cattle.…”

Section: Introductionmentioning

confidence: 99%

Differences in the intestinal microbiota and association of host metabolism with hair coat status in cattle

Wu,

Zhao,

Wang

et al. 2024

Front. Microbiol.

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IntroductionThe hair coat status of cattle serves as an easily observed indicator of economic value in livestock production; however, the underlying mechanism remains largely unknown. Therefore, the objective of the current study was to determine differences in the intestinal microbiota and metabolome of cattle based on a division of with either slick and shining (SHC) or rough and dull (MHC) hair coat in Simmental cows.MethodsEight SHC and eight MHC late-pregnancy Simmental cows (with similar parities, body weights, and body conditions) were selected based on their hair coat status, and blood samples (plasma) from coccygeal venipuncture and fecal samples from the rectum were collected. The intestinal microbiota (in the fecal samples) was characterized by employing 16S rRNA gene sequencing targeting the V3–V4 hypervariable region on the Illumina MiSeq PE300 platform, and plasma samples were subjected to LC–MS/MS-based metabolomics with Progenesis QI 2.3. Plasma macromolecular metabolites were examined for differences in the metabolism of lipids, proteins, mineral elements, and hormones.ResultsNotable differences between the SHC and MHC groups related to host hair coat status were observed in the host metabolome and intestinal microbiota (P < 0.05). The host metabolome was enriched in histidine metabolism, cysteine and methionine metabolism, and purine metabolism in the SHC group, and the intestinal microbiota were also enriched in histidine metabolism (P < 0.05). In the MHC group, the symbiotic relationship transitioned from cooperation to competition in the MHC group, and an uncoupling effect was present in the microbe–metabolite association of intestine microbiota–host interactions. The hubs mediating the relationships between intestinal microbiota and plasma metabolites were the intestinal bacterial genus g__norank_f__Eubacterium_coprostanoligenes_group, plasma inosine, triiodothyronine, and phosphorus, which could be used to differentiate cows’ hair coat status (P < 0.05).ConclusionOverall, the present study identified the relationships between the features of the intestinal microbiota and host hair coat status, thereby providing evidence and a new direction (intestine microbiota–host interplay) for future studies aimed at understanding the hair coat status of cattle.

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“…[ 7 ] Indeed, oral supplementation of probiotics containing Lactobacillus paracasei , a producer of the short chain fatty acid lactate, promoted hair growth in a mouse model. [ 88 ] In the skin, it is known that short chain fatty acids enhance TLR2 responses in sebocytes, suggesting that changes in the metabolic potential of the microbiome drive alterations in the physiological immune state of the host. [ 89 ] However, the interaction between these metabolites and the HF epithelium requires further investigation.…”

Section: General Principles Of the Hydra Holobiont That Can Be Transl...mentioning

confidence: 99%

Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont

et al. 2022

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The microbiome of human hair follicles (HFs) has emerged as an important player in different HF and skin pathologies, yet awaits in-depth exploration. This raises questions regarding the tightly linked interactions between host environment, nutrient dependency of host-associated microbes, microbial metabolism, microbe-microbe interactions and host immunity. The use of simple model systems facilitates addressing generally important questions and testing overarching, therapeutically relevant principles that likely transcend obvious interspecies differences. Here, we evaluate the potential of the freshwater polyp Hydra, to dissect fundamental principles of microbiome regulation by the host, that is the human HF. In particular, we focus on therapeutically targetable host-microbiome interactions, such as nutrient dependency, microbial interactions and host defence. Offering a new lens into the study of HFmicrobiota interactions, we argue that general principles of how Hydra manages its microbiota can inform the development of novel, microbiome-targeting therapeutic interventions in human skin disease.

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Lactobacillus paracasei HY7015 Promotes Hair Growth in a Telogenic Mouse Model

Cited by 7 publications

References 30 publications

Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

Differences in the intestinal microbiota and association of host metabolism with hair coat status in cattle

Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont

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