Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages

Abstract

Over the last few decades, antibiotics have been widely used in animal production to enhance livestock growth and/or to prevent and treat disease (Bengtsson & Greko, 2014). At the same time, the global use of antibiotics has contributed to an increase in antibiotic-resistant bacteria, which can be transmitted to human beings (Garcia et al., 2020). The rise of antibiotic resistance is a worldwide threat, with an estimated death rate of 700,000 deaths per year and a predicted 10,000,000 deaths by 2050 (Interagency Coordination Group on Antimicrobial Resistance, 2019). As a result, the use of antibiotics has been restricted in many countries, following a ban on use for animal growth promotion in Sweden in 1986 (Mingmongkolchai & Panbangred, 2018). Consequently, there is a growing interest in alternatives to antibiotics, including probiotic lactic acid bacteria (LAB; Hiruta, 2015). Labs are widely distributed in nature and have a long history of safe consumption as animal feed or human food. Recently, various species and strains of LAB have been recognized as probiotics, a term that refers to a "live microorganism[s] which when administered in adequate amounts confer a health benefit on the host" (Hill et al., 2014). Some species and strains even exert (in their dead form) health-promoting effects on the host, a phenomenon called paraprobiotics (Taverniti & Guglielmetti, 2011). When alive, probiotics can produce antimicrobial substances, adhere to the intestine, and compete with other bacteria, thereby inhibiting colonization by pathogenic bacteria and improving the intestinal environment. Probiotics also can modulate the immune responses and gastrointestinal

Glucose-lowering effects of a synbiotic combination containing Pediococcus acidilactici in C. elegans and mice

“…Catonella morbi has been associated with occasional infections [ 101 ]. On the other hand, a high abundance of Lactobacillus ingluviei is beneficial, as it exerts an anti-inflammatory effect by modulating cytokine profiles [ 102 ].…”

Assessment of lactic acid bacteria isolated from the chicken digestive tract for potential use as poultry probiotics

“…SCFAs have been reported to decrease cecal pH and indirectly inhibit pathogenic microorganisms susceptible to pH changes, as well as passing into the cells of pathogens causing a change of positive and negative ions resulting in cells becoming unbalanced and inhibiting the growth of pathogens [ 41 ]. In addition, Tsukagoshi et al [ 42 ] reported that L. ingluviei C37 exerted anti-inflammatory effects by modulating cytokine profiles in a mice model. It is interesting to note that the L. ingluviei and L. salivarius increased the concentration of valeric acid approximately three times more than the control group.…”

Oral administration of Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice

“…An overnight culture of B. linens was centrifuged at 8,000× g for 5 min at 4°C. The obtained bacterial pellets were observed under a JSM 7600‐F SEM (JEOL, Tokyo, Japan) according to previously reported methods (Ishida et al, 2020; Tsukagoshi et al, 2020).…”