<i>Lactobacillus</i>
            group and arterial hypertension: A broad review on effects and proposed mechanisms

Gadelha, Danilo Duarte de Assis; Alves, José Luiz de Brito; Costa, Pierre Mendes Da; Luz, Mickael Sousa da; Cavalcanti, Clênia de Oliveira; Bezerril, Fabrícia França; Almeida, Juliana Franco; Cruz, Josiane de Campos; Magnani, Marciane; Balarini, Camille M.; Mascarenhas, Sandra Rodrigues; Braga, Valdir de Andrade; França-Falcão, Maria do Socorro de

doi:10.1080/10408398.2022.2136618

Cited by 8 publications

(3 citation statements)

References 153 publications

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“…are considered beneficial bacteria with probiotic properties [ 34 ]. Our result was unsurprising in view of prior research showing the beneficial effects of Lactobacillus on hypertension [ 35 ]. A former study reported that a high abundance of the genus Macellibacteroides correlated with normal BP in humans [ 36 ].…”

Section: Discussionmentioning

confidence: 71%

Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension

et al. 2023

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Maternal nutrition has a key role in the developmental programming of adult disease. Excessive maternal fructose intake contributes to offspring hypertension. Newly discovered evidence supports the idea that early-life gut microbiota are connected to hypertension later in life. Short-chain fatty acids (SCFAs), butyrate, and propionate are microbiota-derived metabolites, also known as postbiotics. The present study aimed to determine whether maternal butyrate or propionate supplementation can protect offspring from hypertension using a maternal high-fructose (HF) diet rat model. Female Sprague Dawley rats were allocated during pregnancy and lactation to (1) regular chow (ND); (2) 60% high-fructose diet (HF); (3) HF diet plus butyrate (HFB, 400 mg/kg/day); and (4) HF diet plus propionate (HFP, 200 mmol/L). Male offspring were sacrificed at 12 weeks of age. The maternal HF diet impaired the offspring’s BP, which was prevented by perinatal butyrate or propionate supplementation. Both butyrate and propionate treatments similarly increased plasma concentrations of propionic acid, isobutyric acid, and valeric acid in adult offspring. Butyrate supplementation had a more profound impact on trimethylamine N-oxide metabolism and nitric oxide parameters. Whilst propionate treatment mainly influenced gut microbiota composition, it directly altered the abundance of genera Anaerovorax, Lactobacillus, Macellibacteroides, and Rothia. Our results shed new light on targeting gut microbiota through the use of postbiotics to prevent maternal HF intake-primed hypertension, a finding worthy of clinical translation.

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Section: Discussionmentioning

confidence: 71%

Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension

et al. 2023

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“…Lactobacillus has been widely used for balancing blood pressure. 41 According to the literature, Desulfovibrio species level was increased in hypertensive rats. 42 Our findings aligned with these reports.…”

Section: Discussionmentioning

confidence: 99%

Dracocephalum moldavica L. Extract Ameliorates Hypertension Through Modulating the Interaction Between miRNAs and Gut Microbiota in 2K1C Rats

Yu,

Chen,

Chen

et al. 2024

Natural Product Communications

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Aim: To investigate the therapeutic effects of Dracocephalum moldavica L. extract (DME) against hypertension and elucidate the underlying molecular mechanism. Method: A two-kidney one-clip (2K1C) model was established in male Wistar rats, and DME or saline was administered via oral gavage for 4 weeks. Subsequently, the blood pressure was monitored. Fecal microRNAs (miRNAs), gut microbes, and host metabolites were evaluated through miRNA sequencing, 16S rRNA gene sequencing, and serum metabolomics analysis, respectively. Results: DME administration attenuated 2K1C-induced hypertension in rats. Additionally, DME alleviated the dysregulation of miRNA expression and gut microbiota dysbiosis in 2K1C rats. The correlation analysis confirmed the association of the differentially expressed miRNAs with gut microbes. Furthermore, non-targeted metabolomics analysis revealed different metabolic profiles in the serum of 2K1C rats compared to control rats. Interestingly, the changes in those serum metabolites were partially attenuated by DME. The metabolite enrichment analysis demonstrated that the differentially expressed metabolites were mainly involved in three metabolic pathways (Arachidonic acid metabolism, TCA cycle, and Alanine, aspartate and glutamate metabolism). Conclusion: DME can be suggested as an effective intervention in the prevention of hypertension through modulating the miRNAs, gut microbiota, and host metabolites. Our findings may give new insights regarding the treatment of hypertension.

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“…Furthermore, multiple bacterial species were found to be linked to hypertension, including Lactobacillus, Klebsiella, Parabacteroides, Desulfovibrio, and Prevotella [53,54]. Previous evidence showed that Lactobacillus could reduce hypertension involving in modulation of sympathetic activity, oxidative stress, vascular tone, and inflammatory response [55].…”

Section: Gut Microbiota and Dic Risk Factorsmentioning

confidence: 99%

Role of gut microbiota in doxorubicin-induced cardiotoxicity: from pathogenesis to related interventions

Huang,

Li,

et al. 2024

J Transl Med

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Doxorubicin (DOX) is a broad-spectrum and highly efficient anticancer agent, but its clinical implication is limited by lethal cardiotoxicity. Growing evidences have shown that alterations in intestinal microbial composition and function, namely dysbiosis, are closely linked to the progression of DOX-induced cardiotoxicity (DIC) through regulating the gut-microbiota-heart (GMH) axis. The role of gut microbiota and its metabolites in DIC, however, is largely unelucidated. Our review will focus on the potential mechanism between gut microbiota dysbiosis and DIC, so as to provide novel insights into the pathophysiology of DIC. Furthermore, we summarize the underlying interventions of microbial-targeted therapeutics in DIC, encompassing dietary interventions, fecal microbiota transplantation (FMT), probiotics, antibiotics, and natural phytochemicals. Given the emergence of microbial investigation in DIC, finally we aim to point out a novel direction for future research and clinical intervention of DIC, which may be helpful for the DIC patients.

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Lactobacillus group and arterial hypertension: A broad review on effects and proposed mechanisms

Cited by 8 publications

References 153 publications

Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension

Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension

Dracocephalum moldavica L. Extract Ameliorates Hypertension Through Modulating the Interaction Between miRNAs and Gut Microbiota in 2K1C Rats

Role of gut microbiota in doxorubicin-induced cardiotoxicity: from pathogenesis to related interventions

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