<i>Lactobacillus Fermentum</i> ZS40 prevents secondary osteoporosis in Wistar Rat

Liu, Xinhong; Fan, Jiyang; Hu, Jing; Li, Fang; Yi, Ruokun; Tan, Fang

doi:10.1002/fsn3.1824

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…In our study, the GM significantly correlated to metabolites were belonging to two independent families Aerococcacease ( Globicatella ) and Lactobacillaceae ( Lactobacillus ) in the same order Lactobacillales of Firmicutes ( Figures 8 , 10 ). Of which, Lactobacillus has been widely used to prevent PMOP in OVX model ( 18 , 74 , 75 ). As indicated, the IGF-I signaling pathway was involved in this process ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model

Wang

et al. 2022

Front. Endocrinol.

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Postmenopausal osteoporosis (PMOP) is an estrogen deficiency-induced bone loss, which has been shown an association with an altered gut microbiota (GM). Gut microbiota-bone axis has been recognized as a crucial mediator for bone homeostasis. Icariin (ICA) is an effective agent to delay bone loss by regulating the bone homeostasis. Thus, we hypothesize that ICA can prevent bone loss by modulating GM and regulating metabolite alterations. The effects of ICA on bone metabolism improvement in ovariectomized (OVX) rats and their relationships with the GM and fecal metabolites were investigated. Micro-computed tomography (micro-CT) and hematoxylin-eosin (HE) staining showed a typical bone boss in OVX group, while ICA or estradiol (E2) administration exhibited positive effects on bone micro-architecture improvement. The GM such as Actinobacteria, Gammaproteobacteria, Erysipelotrichi, Erysipelotrichales, Enterobacteriales, Actinomycetales, Ruminococcus and Oscillospira significantly correlated to serum bone Gla-protein (BGP), receptor activator of nuclear factor-κB (RANK), receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG) and tartrate resistant acid phosphatase (TRACP). Further t-test revealed a substantial variation of the GM and fecal metabolites in different treatments. Among them, Lachnoclostridium, Butyricimonas, Rikenella, Paraprevolla, Adlercreutzia, Enterorhabdus, Anaerovorax, Allobaculum, Elusimicrobium, Lactococcus, Globicatella and Lactobacillus were probably the key microbial communities driving the change of bile acid, amino acid and fatty acid, thereby leading to an improvement of PMOP. The significant up-regulation of L-Saccharopine, 1-Aminocyclohexadieneacid and linoleic acid after ICA administration suggested important contributions of amino acid and fatty acid metabolisms in the prevention and treatment of PMOP. Taken together, our study has provided new perspectives to better understand the effects of ICA on PMOP improvement by regulating GM and the associated fecal metabolites. Our findings contribute to develop ICA as a potential therapy for PMOP.

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Section: Discussionmentioning

confidence: 99%

Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model

Wang

et al. 2022

Front. Endocrinol.

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“…The suppression of Wnt10b in bone after glucocorticoid treatment was restored by L. reuteri (Schepper et al, 2020), as in the diabetes model described previously. In another model of secondary osteoporosis, in which osteoporosis is induced by vitamin A, Lactobacillus plantarum HFY15 or Lactobacillus fermentum ZS40 isolated from yak yogurt restored BV/TV and other trabecular properties in rats and increased Wnt10b levels in the bone (Liu et al, 2020d;Liu et al, 2020f). Tyagi et al (2018) showed that the probiotic Lactobacillus rhamnosus GG also increased bone mass.…”

Section: Wnt10b As a Therapeutic Agent In Bonementioning

confidence: 99%

The role of WNT10B in physiology and disease: A 10-year update

Perkins

Singh

Abell

et al. 2023

Front. Cell Dev. Biol.

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WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate decisions. WNT10B plays roles in many tissues, including bone, adipocytes, skin, hair, muscle, placenta, and the immune system. Aberrant WNT10B signaling leads to several diseases, such as osteoporosis, obesity, split-hand/foot malformation (SHFM), fibrosis, dental anomalies, and cancer. We reviewed WNT10B a decade ago, and here we provide a comprehensive update to the field. Novel research on WNT10B has expanded to many more tissues and diseases. WNT10B polymorphisms and mutations correlate with many phenotypes, including bone mineral density, obesity, pig litter size, dog elbow dysplasia, and cow body size. In addition, the field has focused on the regulation of WNT10B using upstream mediators, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). We also discussed the therapeutic implications of WNT10B regulation. In summary, research conducted during 2012–2022 revealed several new, diverse functions in the role of WNT10B in physiology and disease.

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“…N., Tb. Th., BMD ↑, the number of OC, Tb spacing ↓ β-catenin, Wnt10b, Lrp5, Lrp6, Runx2, ALP, RANKL, OPG mRNA expression ↑ , DKK1, RANK, TRAP, CTSK mRNA expression ↓ 175 L. Plantarum HFY15 OP Wistar rats BV/TV, Tb. N., Tb.…”

Section: The Prospect Of Probiotics In Osteoporosis Therapymentioning

confidence: 99%

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Lyu¹,

Hu²,

Guo³

et al. 2023

Bone Res

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The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis (OP). Interventions targeting GM modification, including probiotics or antibiotics, have been found to affect bone remodeling. This review provides a comprehensive summary of recent research on the role of GM in regulating bone remodeling and seeks to elucidate the regulatory mechanism from various perspectives, such as the interaction with the immune system, interplay with estrogen or parathyroid hormone (PTH), the impact of GM metabolites, and the effect of extracellular vesicles (EVs). Moreover, this review explores the potential of probiotics as a therapeutic approach for OP. The insights presented may contribute to the development of innovative GM-targeted therapies for OP.

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Lactobacillus Fermentum ZS40 prevents secondary osteoporosis in Wistar Rat

Cited by 7 publications

References 42 publications

Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model

Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model

The role of WNT10B in physiology and disease: A 10-year update

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

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