<i>Lactobacillus acidophilus</i> suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress

Kim, Da Hye; Kim, Soochan; Lee, Jin Ha; Kim, Jae Hyun; Che, Xiumei; Woo, Hyun Jun; Seo, Dong Hyuk; Kim, Tae I.I.; Kim, Won Ho; Kim, Seung Won; Cheon, Jae Hee

doi:10.1111/jgh.14362

Cited by 61 publications

(44 citation statements)

References 48 publications

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“…Additionally, the levels of IL-6, TNF- β , IL-1 β , and IL-17 also decreased in colon tissue [48]. In the same model, Kim et al found that activation of nuclear factor kappa B (NF- κ B) was inhibited and the endoplasmic reticulum (ER) pressure signal pathway was disturbed, leading to increased expression of IL-10 in the colon and increased levels of Th2 and Treg in the spleen [49]. In addition, studies have shown that after oral administration of a mixture of 12 probiotics, zinc, and CoQ10 to arthritic mice induced by collagen, Th17 decreased but Treg increased in the spleen.…”

Section: Immunomodulatory Effects and Mechanisms Of Probiotics Andmentioning

confidence: 99%

“…In BALF, MMP-9 was reduced and IL-10 was increased [83]. In addition, Kim et al fed L. acidophilus to colitis mice and found that M2 macrophages increased in the peritoneal cavity [49]. Through in vitro experiments, some researchers found that coculturing mice bone marrow-derived neutrophils with L. rhamnosus GG could inhibit the phagocytic ability and the cytotoxicity of neutrophils [84].…”

Section: Immunomodulatory Effects and Mechanisms Of Probiotics Andmentioning

confidence: 99%

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Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation

Zhang

Shen

Tao

et al. 2019

Journal of Immunology Research

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Probiotics are commensal or nonpathogenic microbes that confer beneficial effects on the host through several mechanisms such as competitive exclusion, antibacterial effects, and modulation of immune responses. Some probiotics have been found to regulate immune responses via immune regulatory mechanisms. T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. Recently, fecal microbiota transplantation (FMT) has been defined as the transfer of distal gut microbial communities from a healthy individual to a patient’s intestinal tract to cure some immune disorders (mainly inflammatory bowel diseases). The aim of this review was followed through the recent literature survey on immunomodulatory effects and mechanisms of probiotics and FMT and also efficacy and safety of probiotics and FMT in clinical trials and applications.

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Section: Immunomodulatory Effects and Mechanisms Of Probiotics Andmentioning

confidence: 99%

Section: Immunomodulatory Effects and Mechanisms Of Probiotics Andmentioning

confidence: 99%

Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation

Zhang

Shen

Tao

et al. 2019

Journal of Immunology Research

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“…Dysfunction of autophagy by Paneth cells has also been reported to cause not only changes in the gut microbiome, but also improper responses to the altered flora [141]. As described above, the gut flora is closely related to autophagic abnormalities in Paneth cells, and many IBD treatments, particularly those utilizing probiotics, aim to correct intestinal bacterial flora populations [142,143].…”

Section: Role Of Autophagy Of Innate Immune Cells In Ibdmentioning

confidence: 99%

Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease

Iida

Yokoyama

Wagatsuma

et al. 2018

Cells

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Autophagy, an intracellular degradation mechanism, has many immunological functions and is a constitutive process necessary for maintaining cellular homeostasis and organ structure. One of the functions of autophagy is to control the innate immune response. Many studies conducted in recent years have revealed the contribution of autophagy to the innate immune response, and relationships between this process and various diseases have been reported. Inflammatory bowel disease is an intractable disorder with unknown etiology; however, immunological abnormalities in the intestines are known to be involved in the pathology of inflammatory bowel disease, as is dysfunction of autophagy. In Crohn’s disease, many associations with autophagy-related genes, such as ATG16L1, IRGM, NOD2, and others, have been reported. Abnormalities in the ATG16L1 gene, in particular, have been reported to cause autophagic dysfunction, resulting in enhanced production of inflammatory cytokines by macrophages as well as abnormal function of Paneth cells, which are important in intestinal innate immunity. In this review, we provide an overview of the autophagy mechanism in innate immune cells in inflammatory bowel disease.

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“…Of note, L. johnsonii L531 suppressed the intestinal expression of GRP78 and inhibited the production of inflammatory lipocalin 2 in the jejunum of piglets infected with Salmonella. It has been consistently demonstrated that L. acidophilus attenuates mouse colitis by inhibiting ER stress [11]. Taken together, these results indicate that L. johnsonii L531 suppresses ER stress, which contributes to the amelioration of intestinal inflammation caused by Salmonella involving reducing lipocalin 2 production.…”

Section: Discussionmentioning

confidence: 55%

“…We recently reported that an L. johnsonii L531 isolate exhibiting probiotic properties is effective for treating Salmonella infections in piglets [10]. In addition, it was recently shown that L. acidophilus attenuates mouse colitis by alleviating ER stress [11]. However, the role of probiotic bacteria in modulating ER stress during Salmonella infection has not been clearly established.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of Lactobacillus johnsonii L531 in a pig model of Salmonella Infantis infection involves modulation of CCR6+ T cell responses and ER stress

Yang

Xia

et al. 2020

Vet Res

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Probiotic pretreatment is an effective non-antibiotic strategy for preventing or controlling Salmonella infections. We found that Lactobacillus johnsonii L531, isolated from the colon of a clinically healthy weaned piglet, effectively prevented infection with Salmonella enterica serovar Infantis in a pig model. Newly weaned piglets were intragastrically administered Lactobacillus johnsonii L531 at 1.0 × 10 10 CFU/day for 1 week before S. Infantis challenge. Pretreatment with L. johnsonii L531 lessened the severity of diarrhea and ileal inflammation in S. Infantis-infected piglets. Lactobacilli were more abundant in the ileum than jejunum after L. johnsonii L531 pretreatment. Treatment with L. johnsonii L531 reduced the abundance of total bacteria in the ileal mucosa and the production of lipocalin 2 in the jejunum of piglets challenged with Salmonella. Both intestinal morphology and transmission electron microscopy results indicated that L. johnsonii L531 alleviated intestinal tissue damage following S. Infantis challenge, especially in the villus and endoplasmic reticulum (ER). ER stress induced by S. Infantis was attenuated by L. johnsonii L531 treatment. The number of CD4 − CCR6 + T cells decreased following S. Infantis challenge, but the percentage of CCR6 − IFNγ + T cells in peripheral blood increased. In intestinal mesenteric lymph nodes, S. Infantis increased the proportion of CCR6 + IFNγ + T cells, whereas L. johnsonii L531 induced an increase in the proportion of CD4 + CCR6 + T cells in response to S. Infantis infection. Our data thus suggest that L. johnsonii L531 contributes to the maintenance of intestinal homeostasis by modulating T-cell responses and ER stress.

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Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress

Abstract: We showed that LA1 significantly interferes with ER stress and suppresses NF-κB activation. Our findings suggest that LA1 can be used as a potent immunomodulator in IBD treatment, and the regulation of ER stress may have significant implications in treating IBD.

Cited by 61 publications

References 48 publications

Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation

Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation

Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease

Anti-inflammatory effects of Lactobacillus johnsonii L531 in a pig model of Salmonella Infantis infection involves modulation of CCR6+ T cell responses and ER stress

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