<i>Lactobacillus acidophilus</i> INMIA 9602 Er-2 strain 317/402 probiotic regulates growth of commensal <i>Escherichia coli</i> in gut microbiota of familial Mediterranean fever disease subjects

Pepoyan, Astghik; Բալայան, Մարինե; Մանվելյան, Անահիտ; Mamikonyan, Vardan; Isajanyan, M.; Tsaturyan, Vardan; Kamiya, Sh.; Netrebov, Victoria; Chikindas, Michael L.

doi:10.1111/lam.12722

Cited by 21 publications

(9 citation statements)

References 22 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402, a probiotic strain isolated from feces of a healthy newborn infant [ 189 ], produces a small anti-microbial peptide (bacteriocin acidocin LCHV), with a broad spectrum of activity against human pathogens, including methicillin-resistant Staphylococcus aureus and Clostridium difficile [ 190 ]. The strain’s clinically proven positive effects have been confirmed in different studies, also including FMF patients [ 191 ]. Interestingly, Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402 was able to reduce not only Enterobacteriaceae, thus bacterial-related intestinal dysbiosis, but also the relative abundance of Candida albicans , which is increased in FMF-patients.…”

Section: Possible Therapeutic Implicationsmentioning

confidence: 90%

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

Ciaula

Stella

Bonfrate

et al. 2020

Genes

View full text Add to dashboard Cite

The gastrointestinal tract hosts the natural reservoir of microbiota since birth. The microbiota includes various bacteria that establish a progressively mutual relationship with the host. Of note, the composition of gut microbiota is rather individual-specific and, normally, depends on both the host genotype and environmental factors. The study of the bacterial profile in the gut demonstrates that dominant and minor phyla are present in the gastrointestinal tract with bacterial density gradually increasing in oro-aboral direction. The cross-talk between bacteria and host within the gut strongly contributes to the host metabolism, to structural and protective functions. Dysbiosis can develop following aging, diseases, inflammatory status, and antibiotic therapy. Growing evidences show a possible link between the microbiota and Familial Mediterranean Fever (FMF), through a shift of the relative abundance in microbial species. To which extent such perturbations of the microbiota are relevant in driving the phenotypic manifestations of FMF with respect to genetic background, remains to be further investigated.

show abstract

Section: Possible Therapeutic Implicationsmentioning

confidence: 90%

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

Ciaula

Stella

Bonfrate

et al. 2020

Genes

View full text Add to dashboard Cite

show abstract

“…During the 20 th century in Armenia, fermented milk product "Narine" was created. Narine was recommended by the World Health Organization (WHO) as a biologically active food supplement (BAFS), being widely used in the world for the past 50 years [5,19,20]. Choratan, known as Colostrum in the West is an ancient Armenian fermented milk product.…”

Section: Discussionmentioning

confidence: 99%

Armenian fermented milk product Choratan and its influence on gut microbiota in health and pathology

Kalikyan¹,

Avagyan²,

Abrahamyan³

et al. 2018

BCHD

View full text Add to dashboard Cite

Background: Choratan is an ancient Armenian fermented milk product which was recreated as a food supplement by A. Selimyan with the use of innovative technologies. Choratan contains large amounts of active Lactobacillus acidophilus, amino acids, and other bioactive compounds. Material and method: The influence of Choratan on gut microflora was studied in the frame of grant projects through the financing of State Committee of Science of Armenia. One hundred forty-one randomly chosen patients were included in the study with their informed consent. The patients divided into groups by diseases: gastrointestinal, allergic, and diabetes mellitus II type. Healthy patients were included in the fourth group. Bacteriological examinations of faeces were performed on 120 patients before and after Choratan was prescribed with an average dosage of 4-6g a day for 8 weeks. Results: In all the groups, we observed improvements like the increase of normal microflora totally in 63.2%-68.3% and the decrease of conditionally pathogenic and pathogenic bacteria totally in 70.3%-100%. The mean amounts of all microorganisms were improved with statistically significant differences. 77.3% of patients noticed improvements in their conditions, which were more visible in healthy and allergic groups (87.1% and 82.4% respectively) and less impressive in patients with gastrointestinal diseases and diabetes (71.9% and 68.2% respectively).Conclusion: From the results, we can conclude Choratan has positive influence on gut microflora and common health statuses. However, these changes depend on the nature of the disease and initial degree of dysbiotic deviations. Accordingly, we encourage more detailed placebo-controlled investigations.Keywords: diseases; fermented foods; probiotics; bioactive food supplement, gut microflora; chronic diseases

show abstract

“…It is, therefore, plausible that the gut microbiota could be a new therapeutic target and that probiotics could have a role in the management of these patients [22], [52]. Clinical trials and experimental studies have shown that probiotics as well as probiotics' different components or their sterilized variants (paraprobiotics) may be successfully used as biotherapeutic agents for the prevention/treatment of GI diseases [53], [54], [55] and for resistance enhancement in cases of intestinal viral infections [56], [57]. Furthermore, some authors suggest probiotics as agents against viral infections of the respiratory tract [58].…”

Section: Probiotics a Possible Solution To Treat Covid-19mentioning

confidence: 99%

Digestive System and Severe Acute Respiratory Syndrome Coronavirus 2: New Era of Microbiome Study and Gastrointestinal Tract Manifestations during the Coronavirus Disease-19 Pandemic

Kossumov

Mussabay

Pepoyan

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

Main focuses of the review were that during the pandemic of SARS-CoV-2 were gastrointestinal disorders were accompanying. Viral RNA and viral particles are found in feces for more than 30 days. Although SARS-CoV-2 primarily causes lung infection through binding to ACE2 receptors, intestinal epithelial cells, especially enterocytes of the small intestine, also express ACE2 receptors. It is also known that a respiratory viral infection causes disturbances in the gut microbiota. Diet, environmental factors, and genetics play an important role in the formation of gut microbiota, which can affect immunity. The diversity of gut microbiota diminishes in old age, and Covid-19 has been mostly fatal in older patients, further indicating the role that gut microbiota may play in this disease. It is therefore plausible that the gut microbiota could be a new therapeutic target and that probiotics could have a role in the management of these patients.

show abstract

Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402 probiotic regulates growth of commensal Escherichia coli in gut microbiota of familial Mediterranean fever disease subjects

Cited by 21 publications

References 22 publications

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

Armenian fermented milk product Choratan and its influence on gut microbiota in health and pathology

Digestive System and Severe Acute Respiratory Syndrome Coronavirus 2: New Era of Microbiome Study and Gastrointestinal Tract Manifestations during the Coronavirus Disease-19 Pandemic

Contact Info

Product

Resources

About