<i>Lactobacillus acidophilus</i> ATCC 4356 Exopolysaccharides Suppresses Mediators of Inflammation through the Inhibition of TLR2/STAT-3/P38-MAPK Pathway in DEN-Induced Hepatocarcinogenesis in Rats

Khedr, Ola M S; El-Sonbaty, Sawsan M; Moawed, Fatma S M; Kandil, Eman; Abdel-Maksoud, Basma E

doi:10.1080/01635581.2021.1934490

Cited by 16 publications

(7 citation statements)

References 40 publications

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“…Further, the strong and dose‐dependent anti‐inflammatory properties of L. acidophilus spp . has been reported [ 122–126 ] , where combined probiotics showed the most efficacious anti‐inflammatory activity, [ 121,127 ] potentially via NF‐ κ B signaling. [ 128 ]…”

Section: Discussionmentioning

confidence: 99%

Extracellular Proteins Isolated from L. acidophilus as an Osteomicrobiological Therapeutic Agent to Reduce Pathogenic Biofilm Formation, Regulate Chronic Inflammation, and Augment Bone Formation In Vitro

Pugazhendhi,

Seal,

Hughes

et al. 2023

Adv Healthcare Materials

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Periprosthetic joint infection (PJI) is a challenging complication that can occur following joint replacement surgery. Efficacious strategies to prevent and treat PJI and its recurrence remain elusive. Commensal bacteria within the gut convey beneficial effects through a defense strategy named “colonization resistance” thereby preventing pathogenic infection along the intestinal surface. This blueprint may be applicable to PJI. The aim is to investigate Lactobacillus acidophilus spp. and their isolated extracellular‐derived proteins (LaEPs) on PJI‐relevant Staphylococcus aureus, methicillin‐resistant S. aureus, and Escherichia coli planktonic growth and biofilm formation in vitro. The effect of LaEPs on cultured macrophages and osteogenic, and adipogenic human bone marrow‐derived mesenchymal stem cell differentiation is analyzed. Data show electrostatically‐induced probiotic‐pathogen species co‐aggregation and pathogenic growth inhibition together with LaEP‐induced biofilm prevention. LaEPs prime macrophages for enhanced microbial phagocytosis via cathepsin K, reduce lipopolysaccharide‐induced DNA damage and receptor activator nuclear factor‐kappa B ligand expression, and promote a reparative M2 macrophage morphology under chronic inflammatory conditions. LaEPs also significantly augment bone deposition while abating adipogenesis thus holding promise as a potential multimodal therapeutic strategy. Proteomic analyses highlight high abundance of lysyl endopeptidase, and urocanate reductase. Further, in vivo analyses are warranted to elucidate their role in the prevention and treatment of PJIs.

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Section: Discussionmentioning

confidence: 99%

Extracellular Proteins Isolated from L. acidophilus as an Osteomicrobiological Therapeutic Agent to Reduce Pathogenic Biofilm Formation, Regulate Chronic Inflammation, and Augment Bone Formation In Vitro

Pugazhendhi,

Seal,

Hughes

et al. 2023

Adv Healthcare Materials

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“…When hepatocellular carcinoma-induced rats treated with diethylnitrosamine (DEN) and gamma radiation (IR) were treated with EPS produced by L. acidophilus ATCC 4356, serum ALT and γ-GT activities were alleviated. Additionally, MDA, IL-17, and TGF-β1 were also ameliorated, and they showed a preventive effect on HCC through the regulation of the inflammation-related TLR2/STAT-3/P38-MAPK pathway [90]. In vitro, Lactobacillus strains (L. acidophilus HM1, L. buchneri FD2, and L. fermentum HM3) also showed a strong inhibitory activity against liver cancer HepG2 cells and showed selectivity for the apoptosis of cancer cells compared to normal cells [116].…”

Section: Hepatocellular Carcinomamentioning

confidence: 96%

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

Jeong¹,

Park²,

Gi³

et al. 2022

Microorganisms

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Over the past decade, scientific evidence for the properties, functions, and beneficial effects of probiotics for humans has continued to accumulate. Interest in the use of probiotics for humans has increased tremendously. Among various microorganisms, probiotics using bacteria have been widely studied and commercialized, and, among them, Lactobacillus is representative. This genus contains about 300 species of bacteria (recently differentiated into 23 genera) and countless strains have been reported. They improved a wide range of diseases including liver disease, gastrointestinal diseases, respiratory diseases, and autoimmune diseases. Here, we intend to discuss in depth the genus Lactobacillus as a representative probiotic for chronic liver diseases.

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“…The anticancer and immunomodulatory activities of EPSs synthesized by L. acidophilus have been proven to combat colon cancer and inflammatory liver cancer. Khedr and colleagues used male rats as a model and confirmed that L. acidophilus ATCC 4356 EPSs had immunomodulatory effects on liver cancer induced by diethylnitrosamine (DEN) and gamma radiation (IR) [ 63 ]. They proposed that L. acidophilus ATCC 4356 EPSs might be used as a safe and effective probiotic to prevent and treat liver cancer.…”

Section: Biological Functions Of L Acidophilusmentioning

confidence: 99%

The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes

Gao

Chen

et al. 2022

J. Microbiol. Biotechnol.

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Probiotics are live microorganisms that can be consumed by humans in amounts sufficient to offer health-promoting effects. Owing to their various biological functions, probiotics are widely used in biological engineering, industry and agriculture, food safety, and the life and health fields. Lactobacillus acidophilus ( L. acidophilus ), an important human intestinal probiotic, was originally isolated from the human gastrointestinal tract and its functions have been widely studied ever since it was named in 1900. L. acidophilus has been found to play important roles in many aspects of human health. Due to its good resistance against acid and bile salts, it has broad application prospects in functional, edible probiotic preparations. In this review, we explore the basic characteristics and biological functions of L. acidophilus based on the research progress made thus far worldwide. Various problems to be solved regarding the applications of probiotic products and their future development are also discussed.

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Lactobacillus acidophilus ATCC 4356 Exopolysaccharides Suppresses Mediators of Inflammation through the Inhibition of TLR2/STAT-3/P38-MAPK Pathway in DEN-Induced Hepatocarcinogenesis in Rats

Cited by 16 publications

References 40 publications

Extracellular Proteins Isolated from L. acidophilus as an Osteomicrobiological Therapeutic Agent to Reduce Pathogenic Biofilm Formation, Regulate Chronic Inflammation, and Augment Bone Formation In Vitro

Extracellular Proteins Isolated from L. acidophilus as an Osteomicrobiological Therapeutic Agent to Reduce Pathogenic Biofilm Formation, Regulate Chronic Inflammation, and Augment Bone Formation In Vitro

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes

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