<i>Lactiplantibacillus plantarum</i>CCFM1019 attenuate polycystic ovary syndrome through butyrate dependent gut–brain mechanism

He, Yufeng; Mei, Liya; Wang, Luyao; Li, Xiu; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Wang, Gang

doi:10.1039/d1fo01744f

Cited by 15 publications

(9 citation statements)

References 46 publications

(63 reference statements)

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“…[ 31 ] He et al. [ 32 ] reported the levels of butyrate associated with the letrozole‐induced PCOS symptoms in rats, which might due to the butyrate‐dependent gut‐brain mechanism. Hence, we speculated that level of butyric acid may be related to sex hormone levels by the microbiota‐gut‐brain axis.…”

Section: Discussionmentioning

confidence: 99%

Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Yuan

Shangguan

Zhang

et al. 2023

Molecular Nutrition Food Res

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Background The relationship between soy isoflavones (SI)‐induced gut dysbiosis and puberty onset has not been explored, and the protective effect of probiotic is still controversial. This study investigates the action of daidzein (the main components of SI) and probiotic on the age of puberty onset in female mice. Methods and results Changes in the gut microbiota and production of short chain fatty acids (SCFAs) metabolism are highlighted to analyze a possible causative relationship to puberty onset in female c57/bl mice. The results demonstrate that daidzein promotes earlier onset of puberty, and can significantly alter the composition of the fecal bacterial community. Furthermore, daidzein alters the gut microbiota such that levels of butyrate, isovalerate, and hexanoate are reduced. Moreover, a probiotic treatment normalizes the timing of puberty onset, likely due to alteration in the gut microbiota to enhance SCFAs production. Conclusion These findings provide evidence that 95% daidzein has the potential to advance the timing of puberty onset in female mice, and the gut microbiome can be a therapeutic target to regulate the timing of puberty onset.

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Section: Discussionmentioning

confidence: 99%

Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Yuan

Shangguan

Zhang

et al. 2023

Molecular Nutrition Food Res

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“…They suggested that because flaxseed contains a high amount of soluble fiber which can be fermented to SCFAs, downregulating inflammatory pathways in the body and reducing the levels of inflammatory mediators like TNF-α, CRP, and IL-6 [ 123 ]. He et al [ 124 ]showed that Lactiplantibacillus plantarum CCFM1019 improved PCOS symptoms in rats through a butyrate-dependent gut–brain axis. In this study, L. plantarum CCFM1019 reduced the pathological changes in the ovaries and restored testosterone and luteinizing hormone levels.…”

Section: Female Reproductive Tract Microbiota Metabolites With a Focu...mentioning

confidence: 99%

“…In this study, L. plantarum CCFM1019 reduced the pathological changes in the ovaries and restored testosterone and luteinizing hormone levels. Results demonstrated that treatment with L. plantarum CCFM1019 showed higher butyrate and polypeptide YY rates compared to the letrozole-treated rats [ 124 ]. Also, another study showed that acetate can restore ovarian function in experimentally induced PCOS rats [ 125 ].…”

Section: Female Reproductive Tract Microbiota Metabolites With a Focu...mentioning

confidence: 99%

Microbiota metabolites in the female reproductive system: Focused on the short-chain fatty acids

Mirzaei¹,

Kavyani²,

Nabizadeh³

et al. 2023

Heliyon

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“…Increased production of SCFAs after probiotics supplement stimulated GPR41 in the colon to secrete more gut–brain mediators like PYY. They regulated the gut–brain axis, thereby reducing serum testosterone in PCOS rats 74 . Additionally, kisspeptin is a peptide in the hypothalamus to modulate gonadotropin secretion.…”

Section: Gut Microbiota Is a Significant Target For Berberine Treatin...mentioning

confidence: 99%

“…They regulated the gut-brain axis, thereby reducing serum testosterone in PCOS rats. 74 Additionally, kisspeptin is a peptide in the hypothalamus to modulate gonadotropin secretion.…”

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confidence: 99%

Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome

Zhu,

2023

Clin Exp Pharma Physio

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Berberine (BBR) is an isoquinoline alkaloid extracted from Chinese medicinal plants showing a tight correlation with gut microbiota. Polycystic ovary syndrome (PCOS) is a prevalent reproductive and endocrine disorder syndrome among women of childbearing age. Dysbiosis, the imbalance of intestinal microorganisms, is a potential factor that takes part in the pathogenesis of PCOS. Recent evidence indicates that berberine offers promise for treating PCOS. Here, we review the recent research on the interaction between berberine and intestinal microorganisms, including the changes in the structure of gut bacteria, the intestinal metabolites after BBR treatment, and the effect of gut microbiota on the bioavailability of BBR. We also discuss the therapeutic effect of BBR on PCOS in terms of gut microbiota and its potential mechanisms.

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Lactiplantibacillus plantarumCCFM1019 attenuate polycystic ovary syndrome through butyrate dependent gut–brain mechanism

Abstract: Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects women of reproductive age. The gut microbiota has been shown to play a vital role in the pathogenesis of PCOS....

Cited by 15 publications

References 46 publications

Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Microbiota metabolites in the female reproductive system: Focused on the short-chain fatty acids

Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome

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