<i>Lacazia loboi</i>
            gen. nov., comb. nov., the Etiologic Agent of Lobomycosis

Taborda, Paulo R.; Taborda, Valeria A.; McGinnis, Michael R.

doi:10.1128/jcm.37.6.2031-2033.1999

Cited by 127 publications

(54 citation statements)

References 6 publications

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“…Then, in the year 1999, Taborda et al proposed to accommodate the agent in a new genus, Lacazia, renaming it Lacazia loboi. 3 Studies by Mendoza et al have majorly contributed to the clarification of the taxonomic enigma of this agent, placing it in the group of the onygenales dimorphic fungi 23 after amplifying the 18SSU rDNA and 600 bp of the chitin synthetase gene, also suggesting its close phylogenetic relationship with P. brasiliensis, (such as had been previously only presumed on the basis of the morphological and antigenic similarities of both agents), and thereby providing another classification distinct of Paracoccidiodes loboi. 23,24 Since its original description and to date, cases clinically and histologically consistent with infection by Lacazia loboi have been reported in the literature under various descriptive terms including Lobomycosis, Lacaziosis, Jorge LoboÕs disease and LoboÕs disease.…”

Section: Aetiology and Pathologymentioning

confidence: 99%

Lobomycosis: an emerging disease in humans and delphinidae

Paniz-Mondolfi

Talhari

Hoffmann

et al. 2012

Mycoses

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Summary Lobomycosis, a disease caused by the uncultivable dimorphic onygenale fungi Lacazia loboi, remains to date as an enigmatic illness, both due to the impossibility of its aetiological agent to be cultured and grown in vitro, as well as because of its unresponsiveness to specific antifungal treatments. It was first described in the 1930s by Brazilian dermatologist Jorge Lobo and is known to cause cutaneous and subcutaneous localised and widespread infections in humans and dolphins. Soil and vegetation are believed to be the chief habitat of the fungus, however, increasing reports in marine mammals has shifted the attention to the aquatic environment. Infection in humans has also been associated with proximity to water, raising the hypothesis that L. loboi may be a hydrophilic microorganism that penetrates the skin by trauma. Although its occurrence was once thought to be restricted to New World tropical countries, its recent description in African patients has wrecked this belief. Antifungals noted to be effective in the empirical management of other cutaneous/subcutaneous mycoses have proven unsuccessful and unfortunately, no satisfactory therapeutic approach for this cutaneous infection currently exists.

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Section: Aetiology and Pathologymentioning

confidence: 99%

Lobomycosis: an emerging disease in humans and delphinidae

Paniz-Mondolfi

Talhari

Hoffmann

et al. 2012

Mycoses

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“…Lobomycosis is a chronic granulomatous fungal infection of the skin and subcutaneous tissues characterized by nodular or keloid-like lesions, first described by Jorge Lobo in 1930. 1 It is caused by Lacazia loboi, an uncultivable fungus classified in the group of the Onygenales order and Ajellomycetaceae family. 2 Lacazia loboi is saprophytic in soil, vegetation, and water in hot and humid forest areas with large rivers.…”

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confidence: 99%

Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela

Beltrame

Danesi

Farina

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by , an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Several weeks after return, he recalled pruritus and papular skin lesions on the left lower limb, subsequently evolving to a plaque-like lesion. Blastomycosis and cryptococcosis were hypothesized based on microscopic morphology of yeast-like bodies found in three consecutive biopsies, although fungal cultures were always negative. In 2016, exfoliative cytology and a biopsy specimen examination showed round yeast-like organisms (6-12 μm), isolated or in a chain, connected by short tubular projections fulfilling the morphologic diagnostic criteria of spp. The microscopic diagnosis was confirmed by molecular identification.

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“…At least two pathogens cause similar skin nodules in free-ranging small cetaceans. Lacazia loboi (Taborda et al 1999) (syn. Loboa loboi; Caldwell et al 1975) infection is characterized by granulomatous lesions, often in pronounced relief, that may ulcerate and form very large plaques .…”

mentioning

confidence: 99%